C6DLU6 (C6DLU6_MYCTK) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Alanine racemase RuleBase RU000608
EC=5.1.1.1 RuleBase RU000608

Gene names

Ordered Locus Names:

TBMG_03474

Organism

Mycobacterium tuberculosis (strain KZN 1435 / MDR) [Complete proteome] [HAMAP]

Taxonomic identifier

478434 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Actinobacteria › Actinobacteria › Actinobacteridae › Actinomycetales › Corynebacterineae › Mycobacteriaceae › Mycobacterium › Mycobacterium tuberculosis complex › Mycobacterium tuberculosis

Protein attributes

Sequence length	408 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	L-alanine = D-alanine. RuleBase RU000608 SAAS SAAS020622
Cofactor	Pyridoxal phosphate By similarity. RuleBase RU000608 SAAS SAAS020622
Pathway	Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. SAAS SAAS020622 RuleBase RU004247
Sequence similarities	Belongs to the alanine racemase family. RuleBase RU004188

Ontologies

Keywords
Ligand	Pyridoxal phosphate RuleBase RU000608 SAAS SAAS020622
Molecular function	Isomerase RuleBase RU000608 SAAS SAAS020622
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	D-alanine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	alanine racemase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	C6DLU6 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 44FECA297BA7C8E2	FASTA	408	43,388
	10 20 30 40 50 60 MKRFWENVGK PNDTTDGRGT TSLAMTPISQ TPGLLAEAMV DLGAIEHNVR VLREHAGHAQ 70 80 90 100 110 120 LMAVVKADGY GHGATRVAQT ALGAGAAELG VATVDEALAL RADGITAPVL AWLHPPGIDF 130 140 150 160 170 180 GPALLADVQV AVSSLRQLDE LLHAVRRTGR TATVTVKVDT GLNRNGVGPA QFPAMLTALR 190 200 210 220 230 240 QAMAEDAVRL RGLMSHMVYA DKPDDSINDV QAQRFTAFLA QAREQGVRFE VAHLSNSSAT 250 260 270 280 290 300 MARPDLTFDL VRPGIAVYGL SPVPALGDMG LVPAMTVKCA VALVKSIRAG EGVSYGHTWI 310 320 330 340 350 360 APRDTNLALL PIGYADGVFR SLGGRLEVLI NGRRCPGVGR ICMDQFMVDL GPGPLDVAEG 370 380 390 400 DEAILFGPGI RGEPTAQDWA DLVGTIHYEV VTSPRGRITR TYREAENR

References

[1]

"The genome sequence of Mycobacterium tuberculosis strain KZN 1435." Murray M., Pillay M., Borowsky M.L., Young S.K., Zeng Q., Koehrsen M., Alvarado L., Berlin A.M., Borenstein D., Chen Z., Engels R., Freedman E., Gellesch M., Goldberg J., Griggs A., Gujja S., Heiman D.I., Hepburn T.A. , Howarth C., Jen D., Larson L., Lewis B., Mehta T., Park D., Pearson M., Roberts A., Saif S., Shea T.D., Shenoy N., Sisk P., Stolte C., Sykes S.N., Walk T., White J., Yandava C., Haas B., Nusbaum C., Galagan J., Birren B. Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: KZN 1435 / MDR.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001658 Genomic DNA. Translation: ACT26576.1.
RefSeq	YP_003033471.1. NC_012943.1.
3D structure databases
ProteinModelPortal	C6DLU6.
SMR	C6DLU6. Positions 35-405.
ModBase	Search...
Protein-protein interaction databases
STRING	478434.TBMG_03474.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACT26576; ACT26576; TBMG_03474.
GeneID	8164375.
KEGG	mtb:TBMG_03474.
PATRIC	18165127. VBIMycTub122270_3849.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0787.
HOGENOM	HOG000031444.
KO	K01775.
OMA	AAEKQHT.
ProtClustDB	PRK00053.
Enzyme and pathway databases
BioCyc	MTUB478434:GH8E-3593-MONOMER.
UniPathway	UPA00042; UER00497.
Family and domain databases
Gene3D	2.40.37.10. 1 hit.
HAMAP	MF_01201. Ala_racemase.
InterPro	IPR000821. Ala_racemase. IPR009006. Ala_racemase/Decarboxylase_C. IPR011079. Ala_racemase_C. IPR001608. Ala_racemase_N. IPR020622. Ala_racemase_pyridoxalP-BS. [Graphical view]
Pfam	PF00842. Ala_racemase_C. 1 hit. PF01168. Ala_racemase_N. 1 hit. [Graphical view]
PRINTS	PR00992. ALARACEMASE.
SMART	SM01005. Ala_racemase_C. 1 hit. [Graphical view]
SUPFAM	SSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMs	TIGR00492. alr. 1 hit.
PROSITE	PS00395. ALANINE_RACEMASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C6DLU6_MYCTK

Accession

Primary (citable) accession number: C6DLU6

Entry history

Integrated into UniProtKB/TrEMBL:	September 1, 2009
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)