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C6DKY5

- BETB_PECCP

UniProt

C6DKY5 - BETB_PECCP

Protein

NAD/NADP-dependent betaine aldehyde dehydrogenase

Gene

betB

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.UniRule annotation

    Catalytic activityi

    Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

    Cofactori

    Binds 2 potassium ions per subunit.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi93 – 931Potassium 1UniRule annotation
    Active sitei162 – 1621Charge relay systemUniRule annotation
    Metal bindingi180 – 1801Potassium 1; via carbonyl oxygenUniRule annotation
    Binding sitei209 – 2091NAD/NADP; via amide nitrogenUniRule annotation
    Metal bindingi246 – 2461Potassium 2; via carbonyl oxygenUniRule annotation
    Sitei248 – 2481Seems to be a necessary countercharge to the potassium cationsUniRule annotation
    Active sitei252 – 2521Proton acceptorUniRule annotation
    Binding sitei286 – 2861NAD/NADPUniRule annotation
    Binding sitei387 – 3871NAD/NADPUniRule annotation
    Metal bindingi457 – 4571Potassium 2; via carbonyl oxygenUniRule annotation
    Metal bindingi460 – 4601Potassium 2; via carbonyl oxygenUniRule annotation
    Active sitei464 – 4641Charge relay systemUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi150 – 1534NAD/NADPUniRule annotation
    Nucleotide bindingi176 – 1794NAD/NADPUniRule annotation
    Nucleotide bindingi229 – 2346NAD/NADPUniRule annotation

    GO - Molecular functioni

    1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-HAMAP
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Metal-binding, NAD, NADP, Potassium

    Enzyme and pathway databases

    BioCyciPCAR561230:GKCK-2603-MONOMER.
    UniPathwayiUPA00529; UER00386.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    NAD/NADP-dependent betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
    Short name:
    BADHUniRule annotation
    Gene namesi
    Name:betBUniRule annotation
    Ordered Locus Names:PC1_2555
    OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
    Taxonomic identifieri561230 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
    ProteomesiUP000002736: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 490490NAD/NADP-dependent betaine aldehyde dehydrogenasePRO_1000212999Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei286 – 2861Cysteine sulfenic acid (-SOH)UniRule annotation

    Keywords - PTMi

    Oxidation

    Interactioni

    Subunit structurei

    Dimer of dimers.UniRule annotation

    Protein-protein interaction databases

    STRINGi561230.PC1_2555.

    Structurei

    3D structure databases

    ProteinModelPortaliC6DKY5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    KOiK00130.
    OMAiSKMTAME.
    OrthoDBiEOG6BS8QW.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPiMF_00804. BADH.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    TIGRFAMsiTIGR01804. BADH. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6DKY5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRYGLQQLY INGAYVDSTG DDTFDAVNPA NGEIIAQLQS ATVADVDRAV    50
    IAAAAGQKIW AAMTAMERSR ILRRAVDILR ERNDELALLE THDTGKPLSE 100
    TRTVDIVTGA DVLEYYAGLI PMLEGQQIPL RDTSFAYTRR EPLGVVAGIG 150
    AWNYPIQIAL WKSAPALAAG NAMIFKPSEV TSLTALKLAE VYTEAGLPAG 200
    VFNVLTGTGQ SVGQALTTHP GIAKVSFTGG IASGKTVMAN AAGSTLKDVT 250
    MELGGKSPLI VFEDADLDKA ADIAMMANFF SSGQVCTNGT RVFVPQALQT 300
    QFEEKILARV QRIRIGNPTD EAVNFGPLVS FPHRESVLRY IESGKREGAR 350
    VLVGGEPMTD EKYAQGAFVA PTVFTDCRDD MKIVREEIFG PVMSILTYQN 400
    EDEVIRRAND SEYGLAAGVV TGDLNRAHRV IHQLEAGICW INTWGESPAE 450
    MPVGGYKHSG VGRENGITTL EHYTQIKSVQ VELGEFRSVF 490
    Length:490
    Mass (Da):52,954
    Last modified:September 1, 2009 - v1
    Checksum:iCDEC88A163B704B5
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001657 Genomic DNA. Translation: ACT13586.1.
    RefSeqiWP_015840760.1. NC_012917.1.
    YP_003018122.1. NC_012917.1.

    Genome annotation databases

    EnsemblBacteriaiACT13586; ACT13586; PC1_2555.
    GeneIDi8133502.
    KEGGipct:PC1_2555.
    PATRICi20489784. VBIPecCar70489_2575.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001657 Genomic DNA. Translation: ACT13586.1 .
    RefSeqi WP_015840760.1. NC_012917.1.
    YP_003018122.1. NC_012917.1.

    3D structure databases

    ProteinModelPortali C6DKY5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561230.PC1_2555.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT13586 ; ACT13586 ; PC1_2555 .
    GeneIDi 8133502.
    KEGGi pct:PC1_2555.
    PATRICi 20489784. VBIPecCar70489_2575.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    KOi K00130.
    OMAi SKMTAME.
    OrthoDBi EOG6BS8QW.

    Enzyme and pathway databases

    UniPathwayi UPA00529 ; UER00386 .
    BioCyci PCAR561230:GKCK-2603-MONOMER.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    HAMAPi MF_00804. BADH.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR029510. Ald_DH_CS_GLU.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    IPR011264. BADH.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    TIGRFAMsi TIGR01804. BADH. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
      , Balakrishnan V., Glasner J., Perna N.T.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PC1.

    Entry informationi

    Entry nameiBETB_PECCP
    AccessioniPrimary (citable) accession number: C6DKY5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3