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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei471 – 4711UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPCAR561230:GKCK-2602-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PC1_2554
OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
Taxonomic identifieri561230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000002736 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 559559Oxygen-dependent choline dehydrogenasePRO_1000212847Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561230.PC1_2554.

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiNQFEACA.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6DKY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYDYIIIGA GSAGNVLATR LTEESDVSVL LLEAGGPDYR LDFRTQMPAA
60 70 80 90 100
LAFPLQGKRY NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN
110 120 130 140 150
AMDFDNWATM PGLEDWSYLD CLPYFRKAET RDVGSNDYHG ATGPVSVATP
160 170 180 190 200
KMGNNELFHA MVEAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPKGRRAST
210 220 230 240 250
ARGYLDQAKG RKNLTIVTHA LTDKILFEGK RAVGVAYFKG ESPQTVQARR
260 270 280 290 300
EVLLCAGAIA SPQILQRSGV GPKDLLQGLD IPVVHDLPGV GENLQDHLEM
310 320 330 340 350
YLQYACKEPV SLYPALQWFN QPKIGAEWLF SGTGIGASNQ FEAGGFIRSR
360 370 380 390 400
DEFAWPNIQY HFLPVAINYN GSNAVKEHGF QAHVGSMRSL SRGRVQVRSK
410 420 430 440 450
DAREHPSILF NYMSTEQDWQ EFRDAIRITR EIMAQPALDK YRGREISPGL
460 470 480 490 500
EVQTDEELDE FIRTHAETAF HPSCSCKMGE DEMAVVDGQG RVHGMEGLRV
510 520 530 540 550
VDASIMPQII TGNLNATTIM IAEKIADRIR RRQPLPRSRA RYYVSGNTPV

RKAPLKPAS
Length:559
Mass (Da):62,162
Last modified:September 1, 2009 - v1
Checksum:iED4A30801053D8E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001657 Genomic DNA. Translation: ACT13585.1.
RefSeqiWP_015840759.1. NC_012917.1.
YP_003018121.1. NC_012917.1.

Genome annotation databases

EnsemblBacteriaiACT13585; ACT13585; PC1_2554.
GeneIDi8133501.
KEGGipct:PC1_2554.
PATRICi20489782. VBIPecCar70489_2574.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001657 Genomic DNA. Translation: ACT13585.1.
RefSeqiWP_015840759.1. NC_012917.1.
YP_003018121.1. NC_012917.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi561230.PC1_2554.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT13585; ACT13585; PC1_2554.
GeneIDi8133501.
KEGGipct:PC1_2554.
PATRICi20489782. VBIPecCar70489_2574.

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiNQFEACA.
OrthoDBiEOG67HJQP.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.
BioCyciPCAR561230:GKCK-2602-MONOMER.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Balakrishnan V., Glasner J., Perna N.T.
    Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PC1.

Entry informationi

Entry nameiBETA_PECCP
AccessioniPrimary (citable) accession number: C6DKY4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: February 4, 2015
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.