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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi: betaine biosynthesis via choline pathway

This protein is involved in step 1 of the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route).UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Oxygen-dependent choline dehydrogenase (betA)
This subpathway is part of the pathway betaine biosynthesis via choline pathway, which is itself part of Amine and polyamine biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes betaine aldehyde from choline (cytochrome c reductase route), the pathway betaine biosynthesis via choline pathway and in Amine and polyamine biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei471Proton acceptorUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi4 – 33FADUniRule annotationAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandFAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciPCAR561230:G1GF8-2583-MONOMER
UniPathwayiUPA00529; UER00385

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:PC1_2554
OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
Taxonomic identifieri561230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000002736 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002128471 – 559Oxygen-dependent choline dehydrogenaseAdd BLAST559

Interactioni

Protein-protein interaction databases

STRINGi561230.PC1_2554

Structurei

3D structure databases

SMRiC6DKY4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CZ6 Bacteria
COG2303 LUCA
HOGENOMiHOG000139600
KOiK00108
OMAiGWDYAHC
OrthoDBiPOG091H04UT

Family and domain databases

Gene3Di3.50.50.60, 4 hits
4.10.450.10, 2 hits
HAMAPiMF_00750 Choline_dehydrogen, 1 hit
InterProiView protein in InterPro
IPR011533 BetA
IPR036188 FAD/NAD-bd_sf
IPR027424 Glucose_Oxidase_domain_2
IPR012132 GMC_OxRdtase
IPR000172 GMC_OxRdtase_N
IPR007867 GMC_OxRtase_C
PANTHERiPTHR11552:SF157 PTHR11552:SF157, 1 hit
PfamiView protein in Pfam
PF05199 GMC_oxred_C, 1 hit
PF00732 GMC_oxred_N, 1 hit
PIRSFiPIRSF000137 Alcohol_oxidase, 1 hit
TIGRFAMsiTIGR01810 betA, 1 hit
PROSITEiView protein in PROSITE
PS00623 GMC_OXRED_1, 1 hit
PS00624 GMC_OXRED_2, 1 hit

Sequencei

Sequence statusi: Complete.

C6DKY4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEYDYIIIGA GSAGNVLATR LTEESDVSVL LLEAGGPDYR LDFRTQMPAA
60 70 80 90 100
LAFPLQGKRY NWAYETDPEP HMNNRRMECG RGKGLGGSSL INGMCYIRGN
110 120 130 140 150
AMDFDNWATM PGLEDWSYLD CLPYFRKAET RDVGSNDYHG ATGPVSVATP
160 170 180 190 200
KMGNNELFHA MVEAGVQAGY PRTDDLNGYQ QEGFGPMDRT VTPKGRRAST
210 220 230 240 250
ARGYLDQAKG RKNLTIVTHA LTDKILFEGK RAVGVAYFKG ESPQTVQARR
260 270 280 290 300
EVLLCAGAIA SPQILQRSGV GPKDLLQGLD IPVVHDLPGV GENLQDHLEM
310 320 330 340 350
YLQYACKEPV SLYPALQWFN QPKIGAEWLF SGTGIGASNQ FEAGGFIRSR
360 370 380 390 400
DEFAWPNIQY HFLPVAINYN GSNAVKEHGF QAHVGSMRSL SRGRVQVRSK
410 420 430 440 450
DAREHPSILF NYMSTEQDWQ EFRDAIRITR EIMAQPALDK YRGREISPGL
460 470 480 490 500
EVQTDEELDE FIRTHAETAF HPSCSCKMGE DEMAVVDGQG RVHGMEGLRV
510 520 530 540 550
VDASIMPQII TGNLNATTIM IAEKIADRIR RRQPLPRSRA RYYVSGNTPV

RKAPLKPAS
Length:559
Mass (Da):62,162
Last modified:September 1, 2009 - v1
Checksum:iED4A30801053D8E2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001657 Genomic DNA Translation: ACT13585.1
RefSeqiWP_015840759.1, NC_012917.1

Genome annotation databases

EnsemblBacteriaiACT13585; ACT13585; PC1_2554
GeneIDi29703362
KEGGipct:PC1_2554

Similar proteinsi

Entry informationi

Entry nameiBETA_PECCP
AccessioniPrimary (citable) accession number: C6DKY4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 57 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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