ID   UXAC_PECCP              Reviewed;         469 AA.
AC   C6DKE7;
DT   22-SEP-2009, integrated into UniProtKB/Swiss-Prot.
DT   01-SEP-2009, sequence version 1.
DT   27-MAR-2024, entry version 67.
DE   RecName: Full=Uronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE            EC=5.3.1.12 {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Glucuronate isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
DE   AltName: Full=Uronic isomerase {ECO:0000255|HAMAP-Rule:MF_00675};
GN   Name=uxaC {ECO:0000255|HAMAP-Rule:MF_00675};
GN   OrderedLocusNames=PC1_0529;
OS   Pectobacterium carotovorum subsp. carotovorum (strain PC1).
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Enterobacterales;
OC   Pectobacteriaceae; Pectobacterium.
OX   NCBI_TaxID=561230;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PC1;
RG   US DOE Joint Genome Institute;
RA   Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D.,
RA   Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C.,
RA   Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.,
RA   Balakrishnan V., Glasner J., Perna N.T.;
RT   "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1.";
RL   Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-glucuronate = D-fructuronate; Xref=Rhea:RHEA:13049,
CC         ChEBI:CHEBI:58720, ChEBI:CHEBI:59863; EC=5.3.1.12;
CC         Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=aldehydo-D-galacturonate = keto-D-tagaturonate;
CC         Xref=Rhea:RHEA:27702, ChEBI:CHEBI:12952, ChEBI:CHEBI:17886;
CC         EC=5.3.1.12; Evidence={ECO:0000255|HAMAP-Rule:MF_00675};
CC   -!- PATHWAY: Carbohydrate metabolism; pentose and glucuronate
CC       interconversion. {ECO:0000255|HAMAP-Rule:MF_00675}.
CC   -!- SIMILARITY: Belongs to the metallo-dependent hydrolases superfamily.
CC       Uronate isomerase family. {ECO:0000255|HAMAP-Rule:MF_00675}.
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DR   EMBL; CP001657; ACT11584.1; -; Genomic_DNA.
DR   RefSeq; WP_012773236.1; NC_012917.1.
DR   AlphaFoldDB; C6DKE7; -.
DR   SMR; C6DKE7; -.
DR   STRING; 561230.PC1_0529; -.
DR   GeneID; 67795636; -.
DR   KEGG; pct:PC1_0529; -.
DR   eggNOG; COG1904; Bacteria.
DR   HOGENOM; CLU_044465_1_0_6; -.
DR   OrthoDB; 9766564at2; -.
DR   UniPathway; UPA00246; -.
DR   Proteomes; UP000002736; Chromosome.
DR   GO; GO:0008880; F:glucuronate isomerase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006064; P:glucuronate catabolic process; IEA:InterPro.
DR   Gene3D; 3.20.20.140; Metal-dependent hydrolases; 1.
DR   Gene3D; 1.10.2020.10; uronate isomerase, domain 2, chain A; 1.
DR   HAMAP; MF_00675; UxaC; 1.
DR   InterPro; IPR032466; Metal_Hydrolase.
DR   InterPro; IPR003766; Uronate_isomerase.
DR   PANTHER; PTHR30068; URONATE ISOMERASE; 1.
DR   PANTHER; PTHR30068:SF4; URONATE ISOMERASE; 1.
DR   Pfam; PF02614; UxaC; 1.
DR   SUPFAM; SSF51556; Metallo-dependent hydrolases; 1.
PE   3: Inferred from homology;
KW   Isomerase.
FT   CHAIN           1..469
FT                   /note="Uronate isomerase"
FT                   /id="PRO_1000212519"
SQ   SEQUENCE   469 AA;  54004 MW;  BB3210BF70DDCD97 CRC64;
     MPQFLSEDFL LDSEFARRLY HEYAVDQPIF DYHCHLPPEQ IAENYRFKNL YDIWLKGDHY
     KWRAMRTNGV PERLCTGDAS DWEKFEAWAA TVPHTIGNPL YHWTHLELRR PFGVTGTLLS
     PSTAKDIWDR CNAMLERDDF TARGIMQQMN VKMVGTTDDP IDDLRHHKTV AQDSSFSIKV
     LPSWRPDKAF NIELATFNDY MAKLGEVSDT DIRRFSDLQA ALTKRLDHFA AHGCKVSDHA
     LDVVMFAEAD DATLDSILAR RLSGETLSEH EVAQFKTGVL VWLGAEYARR GWVQQYHIGA
     LRNNNLRQFK LLGPDVGFDS INDRPLAQEL SRLLSKQNEE NLLPKTILYC LNPRDNEVLG
     TMIGNFQGEG MPGKMQFGSG WWFNDQKDGM QRQMTQLAQL GLLSRFVGML TDSRSFLSYT
     RHEYFRRILC QMIGRWVEDG EAPADLPLLG EMVKNISFDN AKNYFAIEL
//