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C6DHF6

- GPPA_PECCP

UniProt

C6DHF6 - GPPA_PECCP

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Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

Catalytic activityi

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. exopolyphosphatase activity Source: InterPro
  2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
  3. magnesium ion binding Source: InterPro

GO - Biological processi

  1. guanosine pentaphosphate catabolic process Source: InterPro
  2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
  3. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciPCAR561230:GKCK-4106-MONOMER.
UniPathwayiUPA00908; UER00884.

Names & Taxonomyi

Protein namesi
Recommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
Alternative name(s):
Guanosine pentaphosphate phosphohydrolaseUniRule annotation
pppGpp-5'-phosphohydrolaseUniRule annotation
Gene namesi
Name:gppAUniRule annotation
Ordered Locus Names:PC1_4014
OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
Taxonomic identifieri561230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000002736: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000215466Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561230.PC1_4014.

Structurei

3D structure databases

ProteinModelPortaliC6DHF6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0248.
HOGENOMiHOG000258672.
KOiK01524.
OMAiSYVHWAL.
OrthoDBiEOG6M6JN6.

Family and domain databases

HAMAPiMF_01550. GppA.
InterProiIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

C6DHF6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLSSSSLYAA IDLGSNSFHM LVARETAGSI QTLAKIKRKV RLAAGLDKQN
60 70 80 90 100
RLSQDAMQRG WQCLQLFSER LQDIPQDQVR VVATATLRLA TNADEFLQRA
110 120 130 140 150
QEILGLPIQV ISGEEEARLI YQGVAHTTGG PDARLVVDIG GGSTELATGV
160 170 180 190 200
GAKTTQLISL PMGCVTWLDR YFSDRNLEAG NFERAEQAAR EMLRPVAASL
210 220 230 240 250
REQGWQICVG ASGTVQALQE IMVAQGMDEY ITLPKLRQLK EHAIQCDKLE
260 270 280 290 300
ELEIEGLTLE RALVFPSGLA ILLAIFQELD IKTMTLAGGA LREGLVYGML
310 320 330 340 350
HLPVDQDIRH RTLATLQRRY LLDVEQAKRV STLADNFLQQ VARDWQLDNR
360 370 380 390 400
CRELLRSACL VHEIGLSIDF RQSPQHAAYL IRHSDLPGFT PAQKKLLATL
410 420 430 440 450
LQNQINPVDL MPLSQQNALP VNQAQRLCRL LRLAIIFASR RRDDTLPAVR
460 470 480 490
LRVEGETLRL ILPAGWLSQH PLRAEMLEQE SRWQSYVHWP LMLEETPA
Length:498
Mass (Da):55,777
Last modified:September 1, 2009 - v1
Checksum:i4B1670C7F306E724
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001657 Genomic DNA. Translation: ACT15029.1.
RefSeqiWP_015842108.1. NC_012917.1.
YP_003019565.1. NC_012917.1.

Genome annotation databases

EnsemblBacteriaiACT15029; ACT15029; PC1_4014.
GeneIDi8135005.
KEGGipct:PC1_4014.
PATRICi20492808. VBIPecCar70489_4043.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001657 Genomic DNA. Translation: ACT15029.1 .
RefSeqi WP_015842108.1. NC_012917.1.
YP_003019565.1. NC_012917.1.

3D structure databases

ProteinModelPortali C6DHF6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561230.PC1_4014.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT15029 ; ACT15029 ; PC1_4014 .
GeneIDi 8135005.
KEGGi pct:PC1_4014.
PATRICi 20492808. VBIPecCar70489_4043.

Phylogenomic databases

eggNOGi COG0248.
HOGENOMi HOG000258672.
KOi K01524.
OMAi SYVHWAL.
OrthoDBi EOG6M6JN6.

Enzyme and pathway databases

UniPathwayi UPA00908 ; UER00884 .
BioCyci PCAR561230:GKCK-4106-MONOMER.

Family and domain databases

HAMAPi MF_01550. GppA.
InterProi IPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view ]
Pfami PF02541. Ppx-GppA. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Balakrishnan V., Glasner J., Perna N.T.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PC1.

Entry informationi

Entry nameiGPPA_PECCP
AccessioniPrimary (citable) accession number: C6DHF6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3