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C6DHF6 (GPPA_PECCP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

EC=3.6.1.40
Alternative name(s):
Guanosine pentaphosphate phosphohydrolase
pppGpp-5'-phosphohydrolase
Gene names
Name:gppA
Ordered Locus Names:PC1_4014
OrganismPectobacterium carotovorum subsp. carotovorum (strain PC1) [Complete proteome] [HAMAP]
Taxonomic identifier561230 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length498 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities By similarity. HAMAP-Rule MF_01550

Catalytic activity

Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate. HAMAP-Rule MF_01550

Pathway

Purine metabolism; ppGpp biosynthesis; ppGpp from GTP: step 1/2. HAMAP-Rule MF_01550

Sequence similarities

Belongs to the GppA/Ppx family. GppA subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase HAMAP-Rule MF_01550
PRO_1000215466

Sequences

Sequence LengthMass (Da)Tools
C6DHF6 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 4B1670C7F306E724

FASTA49855,777
        10         20         30         40         50         60 
MLSSSSLYAA IDLGSNSFHM LVARETAGSI QTLAKIKRKV RLAAGLDKQN RLSQDAMQRG 

        70         80         90        100        110        120 
WQCLQLFSER LQDIPQDQVR VVATATLRLA TNADEFLQRA QEILGLPIQV ISGEEEARLI 

       130        140        150        160        170        180 
YQGVAHTTGG PDARLVVDIG GGSTELATGV GAKTTQLISL PMGCVTWLDR YFSDRNLEAG 

       190        200        210        220        230        240 
NFERAEQAAR EMLRPVAASL REQGWQICVG ASGTVQALQE IMVAQGMDEY ITLPKLRQLK 

       250        260        270        280        290        300 
EHAIQCDKLE ELEIEGLTLE RALVFPSGLA ILLAIFQELD IKTMTLAGGA LREGLVYGML 

       310        320        330        340        350        360 
HLPVDQDIRH RTLATLQRRY LLDVEQAKRV STLADNFLQQ VARDWQLDNR CRELLRSACL 

       370        380        390        400        410        420 
VHEIGLSIDF RQSPQHAAYL IRHSDLPGFT PAQKKLLATL LQNQINPVDL MPLSQQNALP 

       430        440        450        460        470        480 
VNQAQRLCRL LRLAIIFASR RRDDTLPAVR LRVEGETLRL ILPAGWLSQH PLRAEMLEQE 

       490 
SRWQSYVHWP LMLEETPA 

« Hide

References

[1]"Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Balakrishnan V., Glasner J., Perna N.T.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001657 Genomic DNA. Translation: ACT15029.1.
RefSeqYP_003019565.1. NC_012917.1.

3D structure databases

ProteinModelPortalC6DHF6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING561230.PC1_4014.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT15029; ACT15029; PC1_4014.
GeneID8135005.
KEGGpct:PC1_4014.
PATRIC20492808. VBIPecCar70489_4043.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0248.
HOGENOMHOG000258672.
KOK01524.
OMAPPRVAEH.
OrthoDBEOG6M6JN6.
ProtClustDBPRK11031.

Enzyme and pathway databases

BioCycPCAR561230:GKCK-4106-MONOMER.
UniPathwayUPA00908; UER00884.

Family and domain databases

HAMAPMF_01550. GppA.
InterProIPR022371. Exopolyphosphatase.
IPR023709. Guo-5TP_3DP_PyrP.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsTIGR03706. exo_poly_only. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGPPA_PECCP
AccessionPrimary (citable) accession number: C6DHF6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: February 19, 2014
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways