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C6DHF6

- GPPA_PECCP

UniProt

C6DHF6 - GPPA_PECCP

Protein

Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase

Gene

gppA

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Conversion of pppGpp to ppGpp. Guanosine pentaphosphate (pppGpp) is a cytoplasmic signaling molecule which together with ppGpp controls the "stringent response", an adaptive process that allows bacteria to respond to amino acid starvation, resulting in the coordinated regulation of numerous cellular activities.UniRule annotation

    Catalytic activityi

    Guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 3',5'-bis(diphosphate) + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. exopolyphosphatase activity Source: InterPro
    2. guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity Source: UniProtKB-EC
    3. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. guanosine pentaphosphate catabolic process Source: InterPro
    2. guanosine tetraphosphate biosynthetic process Source: UniProtKB-UniPathway
    3. polyphosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciPCAR561230:GKCK-4106-MONOMER.
    UniPathwayiUPA00908; UER00884.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Guanosine-5'-triphosphate,3'-diphosphate pyrophosphataseUniRule annotation (EC:3.6.1.40UniRule annotation)
    Alternative name(s):
    Guanosine pentaphosphate phosphohydrolaseUniRule annotation
    pppGpp-5'-phosphohydrolaseUniRule annotation
    Gene namesi
    Name:gppAUniRule annotation
    Ordered Locus Names:PC1_4014
    OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
    Taxonomic identifieri561230 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
    ProteomesiUP000002736: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 498498Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatasePRO_1000215466Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi561230.PC1_4014.

    Structurei

    3D structure databases

    ProteinModelPortaliC6DHF6.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family. GppA subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0248.
    HOGENOMiHOG000258672.
    KOiK01524.
    OMAiSYVHWAL.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    HAMAPiMF_01550. GppA.
    InterProiIPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6DHF6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLSSSSLYAA IDLGSNSFHM LVARETAGSI QTLAKIKRKV RLAAGLDKQN    50
    RLSQDAMQRG WQCLQLFSER LQDIPQDQVR VVATATLRLA TNADEFLQRA 100
    QEILGLPIQV ISGEEEARLI YQGVAHTTGG PDARLVVDIG GGSTELATGV 150
    GAKTTQLISL PMGCVTWLDR YFSDRNLEAG NFERAEQAAR EMLRPVAASL 200
    REQGWQICVG ASGTVQALQE IMVAQGMDEY ITLPKLRQLK EHAIQCDKLE 250
    ELEIEGLTLE RALVFPSGLA ILLAIFQELD IKTMTLAGGA LREGLVYGML 300
    HLPVDQDIRH RTLATLQRRY LLDVEQAKRV STLADNFLQQ VARDWQLDNR 350
    CRELLRSACL VHEIGLSIDF RQSPQHAAYL IRHSDLPGFT PAQKKLLATL 400
    LQNQINPVDL MPLSQQNALP VNQAQRLCRL LRLAIIFASR RRDDTLPAVR 450
    LRVEGETLRL ILPAGWLSQH PLRAEMLEQE SRWQSYVHWP LMLEETPA 498
    Length:498
    Mass (Da):55,777
    Last modified:September 1, 2009 - v1
    Checksum:i4B1670C7F306E724
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001657 Genomic DNA. Translation: ACT15029.1.
    RefSeqiYP_003019565.1. NC_012917.1.

    Genome annotation databases

    EnsemblBacteriaiACT15029; ACT15029; PC1_4014.
    GeneIDi8135005.
    KEGGipct:PC1_4014.
    PATRICi20492808. VBIPecCar70489_4043.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001657 Genomic DNA. Translation: ACT15029.1 .
    RefSeqi YP_003019565.1. NC_012917.1.

    3D structure databases

    ProteinModelPortali C6DHF6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561230.PC1_4014.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT15029 ; ACT15029 ; PC1_4014 .
    GeneIDi 8135005.
    KEGGi pct:PC1_4014.
    PATRICi 20492808. VBIPecCar70489_4043.

    Phylogenomic databases

    eggNOGi COG0248.
    HOGENOMi HOG000258672.
    KOi K01524.
    OMAi SYVHWAL.
    OrthoDBi EOG6M6JN6.

    Enzyme and pathway databases

    UniPathwayi UPA00908 ; UER00884 .
    BioCyci PCAR561230:GKCK-4106-MONOMER.

    Family and domain databases

    HAMAPi MF_01550. GppA.
    InterProi IPR022371. Exopolyphosphatase.
    IPR023709. Guo-5TP_3DP_PyrP.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
      , Balakrishnan V., Glasner J., Perna N.T.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PC1.

    Entry informationi

    Entry nameiGPPA_PECCP
    AccessioniPrimary (citable) accession number: C6DHF6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3