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Protein

6-phosphogluconolactonase

Gene

pgl

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.UniRule annotation

Catalytic activityi

6-phospho-D-glucono-1,5-lactone + H2O = 6-phospho-D-gluconate.UniRule annotation

Pathwayi: pentose phosphate pathway

This protein is involved in step 2 of the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage).UniRule annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Glucose-6-phosphate 1-dehydrogenase (zwf)
  2. 6-phosphogluconolactonase (pgl)
  3. 6-phosphogluconate dehydrogenase, decarboxylating (PC1_1320)
This subpathway is part of the pathway pentose phosphate pathway, which is itself part of Carbohydrate degradation.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-ribulose 5-phosphate from D-glucose 6-phosphate (oxidative stage), the pathway pentose phosphate pathway and in Carbohydrate degradation.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processCarbohydrate metabolism, Glucose metabolism

Enzyme and pathway databases

BioCyciPCAR561230:G1GF8-1309-MONOMER
UniPathwayiUPA00115; UER00409

Names & Taxonomyi

Protein namesi
Recommended name:
6-phosphogluconolactonaseUniRule annotation (EC:3.1.1.31UniRule annotation)
Short name:
6-P-gluconolactonaseUniRule annotation
Gene namesi
Name:pglUniRule annotation
Ordered Locus Names:PC1_1280
OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
Taxonomic identifieri561230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaePectobacterium
Proteomesi
  • UP000002736 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002156981 – 3326-phosphogluconolactonaseAdd BLAST332

Proteomic databases

PRIDEiC6DCH7

Interactioni

Protein-protein interaction databases

STRINGi561230.PC1_1280

Structurei

3D structure databases

ProteinModelPortaliC6DCH7
SMRiC6DCH7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cycloisomerase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HHQ Bacteria
COG2706 LUCA
HOGENOMiHOG000257418
KOiK07404
OMAiEGNWPRD
OrthoDBiPOG091H07R3

Family and domain databases

Gene3Di2.130.10.10, 1 hit
HAMAPiMF_01605 6P_gluconolactonase, 1 hit
InterProiView protein in InterPro
IPR022528 6-phosphogluconolactonase_YbhE
IPR019405 Lactonase_7-beta_prop
IPR015943 WD40/YVTN_repeat-like_dom_sf
PfamiView protein in Pfam
PF10282 Lactonase, 1 hit

Sequencei

Sequence statusi: Complete.

C6DCH7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQQVVYVASP ESQQIHVWQL GAQGNLTLLQ TVDVPGQVQP MVIAPNKRHL
60 70 80 90 100
YVGVRPDFRV LSYRIDEQGK LTEAGVASLP GSPTHLSTDN DGRFLFSASY
110 120 130 140 150
SGACVSVSPI GADGIVGEPI QQLDGLEGCH STNIDPTNRV VWAPCLKEDR
160 170 180 190 200
IRLYDLGATG ELSVHRQAEM TTVAGAGPRH MAFHPNQRFA YCVNELDSSV
210 220 230 240 250
DVYQLDAASG ELEKVQTLDA MPAGFNDTRW AADIHITPNG RFLYISDRTA
260 270 280 290 300
SLLSIFQVSE DGSALTLTGH QPTETQPRGF NIDNTGEFLI SAGQKSQHIE
310 320 330
VYHIDQNTGD LQPLARYAVG QGPMWVSVLA LD
Length:332
Mass (Da):36,139
Last modified:September 1, 2009 - v1
Checksum:iC956F937BA23CC0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001657 Genomic DNA Translation: ACT12327.1
RefSeqiWP_015839555.1, NC_012917.1

Genome annotation databases

EnsemblBacteriaiACT12327; ACT12327; PC1_1280
GeneIDi29704355
KEGGipct:PC1_1280

Similar proteinsi

Entry informationi

Entry namei6PGL_PECCP
AccessioniPrimary (citable) accession number: C6DCH7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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