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C6DAJ6

- LPXB_PECCP

UniProt

C6DAJ6 - LPXB_PECCP

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Protein

Lipid-A-disaccharide synthase

Gene

lpxB

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.UniRule annotation

Catalytic activityi

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. lipid-A-disaccharide synthase activity Source: UniProtKB-EC

GO - Biological processi

  1. lipid A biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Keywords - Biological processi

Lipid A biosynthesis, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciPCAR561230:GKCK-984-MONOMER.
UniPathwayiUPA00359; UER00481.

Names & Taxonomyi

Protein namesi
Recommended name:
Lipid-A-disaccharide synthaseUniRule annotation (EC:2.4.1.182UniRule annotation)
Gene namesi
Name:lpxBUniRule annotation
Ordered Locus Names:PC1_0954
OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
Taxonomic identifieri561230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000002736: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 383383Lipid-A-disaccharide synthasePRO_1000205845Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi561230.PC1_0954.

Structurei

3D structure databases

ProteinModelPortaliC6DAJ6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LpxB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0763.
HOGENOMiHOG000018003.
KOiK00748.
OMAiVSPITYR.
OrthoDBiEOG6FBWZR.

Family and domain databases

HAMAPiMF_00392. LpxB.
InterProiIPR003835. Glyco_trans_19.
[Graphical view]
PfamiPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00215. lpxB. 1 hit.

Sequencei

Sequence statusi: Complete.

C6DAJ6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSSRPLTIGL VAGETSGDIL GAGLIRSLKE KVPDARFVGV AGPRMQAEGC
60 70 80 90 100
EAWYEMEELA VMGIVEVLGR LPRLLKIRRD LTQRFSELQP DVFVGIDAPD
110 120 130 140 150
FNITLEGNLK QRGINTIHYV SPSVWAWRQK RVFKIGKATN LVLAFLPFEK
160 170 180 190 200
AFYDRFNVPC RFIGHTMADA MPLHPDKQAA RATLGIAPEA HCLALLPGSR
210 220 230 240 250
NAEVEMLSAD FLKTAVLLRE HFPDLEIVVP LVNSKRREQF EQIKSSVAPD
260 270 280 290 300
LRVHLLDGQA REAMIASDAA LLASGTAALE CMLAKCPMVV GYRMKPFTFW
310 320 330 340 350
LAQRLVKTQW VSLPNLLAGR ELVTELLQTD CTPDKLAAAL LPLFADSDKT
360 370 380
AALRTTFVDL HQQIRCNADE QAAQAVLELV KPR
Length:383
Mass (Da):42,434
Last modified:September 1, 2009 - v1
Checksum:i23E8835C44E03B8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001657 Genomic DNA. Translation: ACT12004.1.
RefSeqiYP_003016540.1. NC_012917.1.

Genome annotation databases

EnsemblBacteriaiACT12004; ACT12004; PC1_0954.
GeneIDi8131883.
KEGGipct:PC1_0954.
PATRICi20486498. VBIPecCar70489_0950.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001657 Genomic DNA. Translation: ACT12004.1 .
RefSeqi YP_003016540.1. NC_012917.1.

3D structure databases

ProteinModelPortali C6DAJ6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561230.PC1_0954.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT12004 ; ACT12004 ; PC1_0954 .
GeneIDi 8131883.
KEGGi pct:PC1_0954.
PATRICi 20486498. VBIPecCar70489_0950.

Phylogenomic databases

eggNOGi COG0763.
HOGENOMi HOG000018003.
KOi K00748.
OMAi VSPITYR.
OrthoDBi EOG6FBWZR.

Enzyme and pathway databases

UniPathwayi UPA00359 ; UER00481 .
BioCyci PCAR561230:GKCK-984-MONOMER.

Family and domain databases

HAMAPi MF_00392. LpxB.
InterProi IPR003835. Glyco_trans_19.
[Graphical view ]
Pfami PF02684. LpxB. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00215. lpxB. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Balakrishnan V., Glasner J., Perna N.T.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PC1.

Entry informationi

Entry nameiLPXB_PECCP
AccessioniPrimary (citable) accession number: C6DAJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3