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C6D8X1

- GCSP_PECCP

UniProt

C6D8X1 - GCSP_PECCP

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Protein
Glycine dehydrogenase (decarboxylating)
Gene
gcvP, PC1_0624
Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciPCAR561230:GKCK-647-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating) (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene namesi
Name:gcvP
Ordered Locus Names:PC1_0624
OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
Taxonomic identifieri561230 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
ProteomesiUP000002736: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 956956Glycine dehydrogenase (decarboxylating)UniRule annotation
PRO_1000212655Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei708 – 7081N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Protein-protein interaction databases

STRINGi561230.PC1_0624.

Structurei

3D structure databases

ProteinModelPortaliC6D8X1.

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiFDSRPYS.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

C6D8X1-1 [UniParc]FASTAAdd to Basket

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MTQTLSQLEH DGAFIERHIG PSVSQQQHML SVVGATSLDA LIRQIVPQDI    50
QLPSPPAVGE AATEHEALSE LKAIAGRNQR YKSYIGMGYS AVLMPPVILR 100
NVLENPGWYT AYTPYQPEVS QGRLEALLNF QQVTQDLTGL DLASASLLDE 150
ATAAAEAMAM AKRISKLKQA ERFFVADDVH PQTLDVVRTR AETFGFEIVV 200
GKAEDALKDD AVFGVLLQQV GTTGELHDYS DLMAALKARK VVSCVASDIM 250
ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFACR DEHKRAMPGR 300
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV 350
FHGPEGLKRI AGRIHRLTDI LAAGLTQGGL LLRHRSWFDT LTIEVADKDA 400
VLSRALSFGI NLRSDLASAV GITLDEATTR EDVLALFAVL LGDDHGLDIG 450
ALDAAISQQA ATIPAGLLRQ DAILSHPVFN RYHSETEMMR YLHRLARKDL 500
ALNQAMIPLG SCTMKLNAAA EMLPITWPEF AELHPFCPPE QALGYRQMIE 550
QLSGWLVQLT GYDAICMQPN SGAQGEYAGL LAIRRYHESR NEAGRHLCLI 600
PSSAHGTNPA SAQMAGMDVV VVACDKQGNI DLHDLREKAQ AAGEQLSCIM 650
VTYPSTHGVY EETIREVCQI VHQYGGQVYL DGANMNAQVG ITTPGYIGAD 700
VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHQVV KIDGVLTEQG 750
AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQMAILNAN YIATRLQQAY 800
PVLYTGRDGR VAHECILDIR PLKESTGISE MDIAKRLIDY GFHAPTMSFP 850
VAGTLMVEPT ESESQVEIDR FVDAMLAIRA EINRVAQGEW PLDDNPLVNA 900
PHTQAELVAD WAHPYSRELA VFPAGSEHKY WPSVKRLDDV YGDRNLFCSC 950
VPMSDY 956
Length:956
Mass (Da):103,905
Last modified:September 1, 2009 - v1
Checksum:i27B74740AAB76B49
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001657 Genomic DNA. Translation: ACT11679.1.
RefSeqiWP_012773326.1. NC_012917.1.
YP_003016215.1. NC_012917.1.

Genome annotation databases

EnsemblBacteriaiACT11679; ACT11679; PC1_0624.
GeneIDi8131547.
KEGGipct:PC1_0624.
PATRICi20485832. VBIPecCar70489_0622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001657 Genomic DNA. Translation: ACT11679.1 .
RefSeqi WP_012773326.1. NC_012917.1.
YP_003016215.1. NC_012917.1.

3D structure databases

ProteinModelPortali C6D8X1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561230.PC1_0624.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT11679 ; ACT11679 ; PC1_0624 .
GeneIDi 8131547.
KEGGi pct:PC1_0624.
PATRICi 20485832. VBIPecCar70489_0622.

Phylogenomic databases

eggNOGi COG1003.
HOGENOMi HOG000239369.
KOi K00281.
OMAi FDSRPYS.
OrthoDBi EOG6HMXDX.

Enzyme and pathway databases

BioCyci PCAR561230:GKCK-647-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 2 hits.
HAMAPi MF_00711. GcvP.
InterProi IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 2 hits.
[Graphical view ]
SUPFAMi SSF53383. SSF53383. 3 hits.
TIGRFAMsi TIGR00461. gcvP. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
    , Balakrishnan V., Glasner J., Perna N.T.
    Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: PC1.

Entry informationi

Entry nameiGCSP_PECCP
AccessioniPrimary (citable) accession number: C6D8X1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: September 3, 2014
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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