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C6D8X1

- GCSP_PECCP

UniProt

C6D8X1 - GCSP_PECCP

Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Pectobacterium carotovorum subsp. carotovorum (strain PC1)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine decarboxylation via glycine cleavage system Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    BioCyciPCAR561230:GKCK-647-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-proteinUniRule annotation
    Glycine decarboxylaseUniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
    Gene namesi
    Name:gcvPUniRule annotation
    Ordered Locus Names:PC1_0624
    OrganismiPectobacterium carotovorum subsp. carotovorum (strain PC1)
    Taxonomic identifieri561230 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium
    ProteomesiUP000002736: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 956956Glycine dehydrogenase (decarboxylating)PRO_1000212655Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei708 – 7081N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

    Protein-protein interaction databases

    STRINGi561230.PC1_0624.

    Structurei

    3D structure databases

    ProteinModelPortaliC6D8X1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1003.
    HOGENOMiHOG000239369.
    KOiK00281.
    OMAiFDSRPYS.
    OrthoDBiEOG6HMXDX.

    Family and domain databases

    Gene3Di3.40.640.10. 2 hits.
    HAMAPiMF_00711. GcvP.
    InterProiIPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 2 hits.
    [Graphical view]
    SUPFAMiSSF53383. SSF53383. 3 hits.
    TIGRFAMsiTIGR00461. gcvP. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6D8X1-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTQTLSQLEH DGAFIERHIG PSVSQQQHML SVVGATSLDA LIRQIVPQDI    50
    QLPSPPAVGE AATEHEALSE LKAIAGRNQR YKSYIGMGYS AVLMPPVILR 100
    NVLENPGWYT AYTPYQPEVS QGRLEALLNF QQVTQDLTGL DLASASLLDE 150
    ATAAAEAMAM AKRISKLKQA ERFFVADDVH PQTLDVVRTR AETFGFEIVV 200
    GKAEDALKDD AVFGVLLQQV GTTGELHDYS DLMAALKARK VVSCVASDIM 250
    ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFACR DEHKRAMPGR 300
    IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV 350
    FHGPEGLKRI AGRIHRLTDI LAAGLTQGGL LLRHRSWFDT LTIEVADKDA 400
    VLSRALSFGI NLRSDLASAV GITLDEATTR EDVLALFAVL LGDDHGLDIG 450
    ALDAAISQQA ATIPAGLLRQ DAILSHPVFN RYHSETEMMR YLHRLARKDL 500
    ALNQAMIPLG SCTMKLNAAA EMLPITWPEF AELHPFCPPE QALGYRQMIE 550
    QLSGWLVQLT GYDAICMQPN SGAQGEYAGL LAIRRYHESR NEAGRHLCLI 600
    PSSAHGTNPA SAQMAGMDVV VVACDKQGNI DLHDLREKAQ AAGEQLSCIM 650
    VTYPSTHGVY EETIREVCQI VHQYGGQVYL DGANMNAQVG ITTPGYIGAD 700
    VSHLNLHKTF CIPHGGGGPG MGPIGVKAHL APFVPGHQVV KIDGVLTEQG 750
    AVSAAPFGSA SILPISWMYI RMMGAEGLKQ ASQMAILNAN YIATRLQQAY 800
    PVLYTGRDGR VAHECILDIR PLKESTGISE MDIAKRLIDY GFHAPTMSFP 850
    VAGTLMVEPT ESESQVEIDR FVDAMLAIRA EINRVAQGEW PLDDNPLVNA 900
    PHTQAELVAD WAHPYSRELA VFPAGSEHKY WPSVKRLDDV YGDRNLFCSC 950
    VPMSDY 956
    Length:956
    Mass (Da):103,905
    Last modified:September 1, 2009 - v1
    Checksum:i27B74740AAB76B49
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001657 Genomic DNA. Translation: ACT11679.1.
    RefSeqiWP_012773326.1. NC_012917.1.
    YP_003016215.1. NC_012917.1.

    Genome annotation databases

    EnsemblBacteriaiACT11679; ACT11679; PC1_0624.
    GeneIDi8131547.
    KEGGipct:PC1_0624.
    PATRICi20485832. VBIPecCar70489_0622.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001657 Genomic DNA. Translation: ACT11679.1 .
    RefSeqi WP_012773326.1. NC_012917.1.
    YP_003016215.1. NC_012917.1.

    3D structure databases

    ProteinModelPortali C6D8X1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561230.PC1_0624.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT11679 ; ACT11679 ; PC1_0624 .
    GeneIDi 8131547.
    KEGGi pct:PC1_0624.
    PATRICi 20485832. VBIPecCar70489_0622.

    Phylogenomic databases

    eggNOGi COG1003.
    HOGENOMi HOG000239369.
    KOi K00281.
    OMAi FDSRPYS.
    OrthoDBi EOG6HMXDX.

    Enzyme and pathway databases

    BioCyci PCAR561230:GKCK-647-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 2 hits.
    HAMAPi MF_00711. GcvP.
    InterProi IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR003437. GDC_P_homo.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 2 hits.
    [Graphical view ]
    SUPFAMi SSF53383. SSF53383. 3 hits.
    TIGRFAMsi TIGR00461. gcvP. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
      US DOE Joint Genome Institute
      Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N.
      , Balakrishnan V., Glasner J., Perna N.T.
      Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: PC1.

    Entry informationi

    Entry nameiGCSP_PECCP
    AccessioniPrimary (citable) accession number: C6D8X1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3