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C6D8X1 (GCSP_PECCP) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:PC1_0624
OrganismPectobacterium carotovorum subsp. carotovorum (strain PC1) [Complete proteome] [HAMAP]
Taxonomic identifier561230 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaePectobacterium

Protein attributes

Sequence length956 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 956956Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_1000212655

Amino acid modifications

Modified residue7081N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
C6D8X1 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 27B74740AAB76B49

FASTA956103,905
        10         20         30         40         50         60 
MTQTLSQLEH DGAFIERHIG PSVSQQQHML SVVGATSLDA LIRQIVPQDI QLPSPPAVGE 

        70         80         90        100        110        120 
AATEHEALSE LKAIAGRNQR YKSYIGMGYS AVLMPPVILR NVLENPGWYT AYTPYQPEVS 

       130        140        150        160        170        180 
QGRLEALLNF QQVTQDLTGL DLASASLLDE ATAAAEAMAM AKRISKLKQA ERFFVADDVH 

       190        200        210        220        230        240 
PQTLDVVRTR AETFGFEIVV GKAEDALKDD AVFGVLLQQV GTTGELHDYS DLMAALKARK 

       250        260        270        280        290        300 
VVSCVASDIM ALVLLTAPGK QGADIVFGSA QRFGVPMGYG GPHAAFFACR DEHKRAMPGR 

       310        320        330        340        350        360 
IIGVSRDAAG NTALRMAMQT REQHIRREKA NSNICTSQVL LANIAGMYAV FHGPEGLKRI 

       370        380        390        400        410        420 
AGRIHRLTDI LAAGLTQGGL LLRHRSWFDT LTIEVADKDA VLSRALSFGI NLRSDLASAV 

       430        440        450        460        470        480 
GITLDEATTR EDVLALFAVL LGDDHGLDIG ALDAAISQQA ATIPAGLLRQ DAILSHPVFN 

       490        500        510        520        530        540 
RYHSETEMMR YLHRLARKDL ALNQAMIPLG SCTMKLNAAA EMLPITWPEF AELHPFCPPE 

       550        560        570        580        590        600 
QALGYRQMIE QLSGWLVQLT GYDAICMQPN SGAQGEYAGL LAIRRYHESR NEAGRHLCLI 

       610        620        630        640        650        660 
PSSAHGTNPA SAQMAGMDVV VVACDKQGNI DLHDLREKAQ AAGEQLSCIM VTYPSTHGVY 

       670        680        690        700        710        720 
EETIREVCQI VHQYGGQVYL DGANMNAQVG ITTPGYIGAD VSHLNLHKTF CIPHGGGGPG 

       730        740        750        760        770        780 
MGPIGVKAHL APFVPGHQVV KIDGVLTEQG AVSAAPFGSA SILPISWMYI RMMGAEGLKQ 

       790        800        810        820        830        840 
ASQMAILNAN YIATRLQQAY PVLYTGRDGR VAHECILDIR PLKESTGISE MDIAKRLIDY 

       850        860        870        880        890        900 
GFHAPTMSFP VAGTLMVEPT ESESQVEIDR FVDAMLAIRA EINRVAQGEW PLDDNPLVNA 

       910        920        930        940        950 
PHTQAELVAD WAHPYSRELA VFPAGSEHKY WPSVKRLDDV YGDRNLFCSC VPMSDY 

« Hide

References

[1]"Complete sequence of Pectobacterium carotovorum subsp. carotovorum PC1."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Mikhailova N. expand/collapse author list , Balakrishnan V., Glasner J., Perna N.T.
Submitted (JUL-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: PC1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001657 Genomic DNA. Translation: ACT11679.1.
RefSeqYP_003016215.1. NC_012917.1.

3D structure databases

ProteinModelPortalC6D8X1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING561230.PC1_0624.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT11679; ACT11679; PC1_0624.
GeneID8131547.
KEGGpct:PC1_0624.
PATRIC20485832. VBIPecCar70489_0622.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAQTMVCDL.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycPCAR561230:GKCK-647-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_PECCP
AccessionPrimary (citable) accession number: C6D8X1
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: February 19, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families