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Protein

Phosphonoacetaldehyde hydrolase

Gene

phnX

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Involved in phosphonate degradation.UniRule annotation

Catalytic activityi

Phosphonoacetaldehyde + H2O = acetaldehyde + phosphate.UniRule annotation

Cofactori

Mg2+UniRule annotationNote: Binds 1 Mg2+ ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei9 – 91NucleophileUniRule annotation
Metal bindingi9 – 91MagnesiumUniRule annotation
Metal bindingi11 – 111Magnesium; via carbonyl oxygenUniRule annotation
Active sitei50 – 501Schiff-base intermediate with substrateUniRule annotation
Metal bindingi183 – 1831MagnesiumUniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphonoacetaldehyde hydrolase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. organic phosphonate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

HydrolaseUniRule annotationImported

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Schiff baseUniRule annotation

Enzyme and pathway databases

BioCyciPSP324057:GH5H-4449-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphonoacetaldehyde hydrolaseUniRule annotation (EC:3.11.1.1UniRule annotation)
Short name:
PhosphonataseUniRule annotation
Alternative name(s):
Phosphonoacetaldehyde phosphonohydrolaseUniRule annotation
Gene namesi
Name:phnXUniRule annotation
Ordered Locus Names:Pjdr2_4351Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002510 Componenti: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi324057.Pjdr2_4351.

Structurei

3D structure databases

ProteinModelPortaliC6D7U2.
SMRiC6D7U2. Positions 3-257.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HAD-like hydrolase superfamily. PhnX family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000217971.
KOiK05306.
OMAiFDWAGTM.
OrthoDBiEOG6ZH2FH.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01375. PhnX.
InterProiIPR023214. HAD-like_dom.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01422. phosphonatase. 1 hit.

Sequencei

Sequence statusi: Complete.

C6D7U2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMIKAVMLDW AGTMVDFGCF APLNVFVEVF ARKGVQVTVE EARQPMGMLK
60 70 80 90 100
RDHIAAMCQM ERIAGVWEGL YGRKPGEADI DELYADFEPL LFSTLKDYAK
110 120 130 140 150
PVPGAVELAD RLRSQGIAIG STTGYTRAMM DVVCKGAKEQ GYEPDTLVTP
160 170 180 190 200
TEVSAGRPYP WMIYRNAEML GVYPMHHIVK AGDTVSDMLE GVNAGCWTVG
210 220 230 240 250
VIVGSSELGM TEEEVNGCED AELSERKAAV AARLQAAGAH YVIDRIGQLD
260
SLIAQINARM ERGERP
Length:266
Mass (Da):29,114
Last modified:September 1, 2009 - v1
Checksum:iBC81273470F1E237
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA. Translation: ACT02972.1.
RefSeqiWP_015845912.1. NC_012914.1.
YP_003013058.1. NC_012914.1.

Genome annotation databases

EnsemblBacteriaiACT02972; ACT02972; Pjdr2_4351.
KEGGipjd:Pjdr2_4351.
PATRICi22839259. VBIPaeSp118865_4337.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA. Translation: ACT02972.1.
RefSeqiWP_015845912.1. NC_012914.1.
YP_003013058.1. NC_012914.1.

3D structure databases

ProteinModelPortaliC6D7U2.
SMRiC6D7U2. Positions 3-257.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324057.Pjdr2_4351.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACT02972; ACT02972; Pjdr2_4351.
KEGGipjd:Pjdr2_4351.
PATRICi22839259. VBIPaeSp118865_4337.

Phylogenomic databases

eggNOGiCOG0637.
HOGENOMiHOG000217971.
KOiK05306.
OMAiFDWAGTM.
OrthoDBiEOG6ZH2FH.

Enzyme and pathway databases

BioCyciPSP324057:GH5H-4449-MONOMER.

Family and domain databases

Gene3Di1.10.150.240. 1 hit.
3.40.50.1000. 2 hits.
HAMAPiMF_01375. PhnX.
InterProiIPR023214. HAD-like_dom.
IPR023198. PGP_dom2.
IPR006323. Phosphonoacetald_hydro.
[Graphical view]
PfamiPF13419. HAD_2. 1 hit.
[Graphical view]
SUPFAMiSSF56784. SSF56784. 1 hit.
TIGRFAMsiTIGR01422. phosphonatase. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JDR-2Imported.

Entry informationi

Entry nameiC6D7U2_PAESJ
AccessioniPrimary (citable) accession number: C6D7U2
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 1, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.