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C6D530

- C6D530_PAESJ

UniProt

C6D530 - C6D530_PAESJ

Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 35 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation
    Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation

    Catalytic activityi

    UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation

    GO - Molecular functioni

    1. RNA binding Source: UniProtKB-HAMAP
    2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
    2. nucleoside metabolic process Source: InterPro
    3. regulation of transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    GlycosyltransferaseUniRule annotationSAAS annotationImported, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation, Transcription terminationUniRule annotation

    Keywords - Ligandi

    RNA-bindingUniRule annotation

    Enzyme and pathway databases

    BioCyciPSP324057:GH5H-3958-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional protein PyrRUniRule annotation
    Gene namesi
    Name:pyrRUniRule annotation
    Ordered Locus Names:Pjdr2_3865Imported
    OrganismiPaenibacillus sp. (strain JDR-2)Imported
    Taxonomic identifieri324057 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
    ProteomesiUP000002510: Chromosome

    Interactioni

    Subunit structurei

    Homodimer and homohexamer; in equilibrium.UniRule annotation

    Protein-protein interaction databases

    STRINGi324057.Pjdr2_3865.

    Structurei

    3D structure databases

    ProteinModelPortaliC6D530.
    SMRiC6D530. Positions 7-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi107 – 11913PRPP-bindingUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2065.
    HOGENOMiHOG000245770.
    KOiK02825.
    OMAiLMDMGRP.
    OrthoDBiEOG61VZD8.

    Family and domain databases

    Gene3Di3.40.50.2020. 1 hit.
    HAMAPiMF_01219. PyrR.
    InterProiIPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view]
    PfamiPF00156. Pribosyltran. 1 hit.
    [Graphical view]
    SUPFAMiSSF53271. SSF53271. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6D530-1 [UniParc]FASTAAdd to Basket

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    MEEEHLVIMD ETAIRRALTR IAHEIVEKNK GIDNCVLIGI RTRGIYLARR    50
    IADRIQDIEG KPVEVRELDI TSYRDDRKAA SVDTRVELAA VIGDLNGELF 100
    SAHDKKVILC DDVLFTGRTI RAAMDALMDC GRPESIQLAV LVDRGHRELP 150
    IRPDYVGKNV PTSKQEQIDV SLTEIDLKDQ VMIIHQRGQV 190
    Length:190
    Mass (Da):21,464
    Last modified:September 1, 2009 - v1
    Checksum:i80202698C9002072
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001656 Genomic DNA. Translation: ACT02495.1.
    RefSeqiWP_015845435.1. NC_012914.1.
    YP_003012581.1. NC_012914.1.

    Genome annotation databases

    EnsemblBacteriaiACT02495; ACT02495; Pjdr2_3865.
    GeneIDi8126390.
    KEGGipjd:Pjdr2_3865.
    PATRICi22838265. VBIPaeSp118865_3846.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001656 Genomic DNA. Translation: ACT02495.1 .
    RefSeqi WP_015845435.1. NC_012914.1.
    YP_003012581.1. NC_012914.1.

    3D structure databases

    ProteinModelPortali C6D530.
    SMRi C6D530. Positions 7-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324057.Pjdr2_3865.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT02495 ; ACT02495 ; Pjdr2_3865 .
    GeneIDi 8126390.
    KEGGi pjd:Pjdr2_3865.
    PATRICi 22838265. VBIPaeSp118865_3846.

    Phylogenomic databases

    eggNOGi COG2065.
    HOGENOMi HOG000245770.
    KOi K02825.
    OMAi LMDMGRP.
    OrthoDBi EOG61VZD8.

    Enzyme and pathway databases

    BioCyci PSP324057:GH5H-3958-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.2020. 1 hit.
    HAMAPi MF_01219. PyrR.
    InterProi IPR000836. PRibTrfase_dom.
    IPR029057. PRTase-like.
    IPR023050. PyrR.
    [Graphical view ]
    Pfami PF00156. Pribosyltran. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53271. SSF53271. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JDR-2Imported.

    Entry informationi

    Entry nameiC6D530_PAESJ
    AccessioniPrimary (citable) accession number: C6D530
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 35 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3