C6D530 (C6D530_PAESJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Bifunctional protein PyrR HAMAP-Rule MF_01219

Gene names

Name:	pyrR HAMAP-Rule MF_01219
Ordered Locus Names:	Pjdr2_3865

Organism

Paenibacillus sp. (strain JDR-2) [Complete proteome] [HAMAP] EMBL ACT02495.1

Taxonomic identifier

324057 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Firmicutes › Bacilli › Bacillales › Paenibacillaceae › Paenibacillus

Protein attributes

Sequence length	190 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant By similarity. HAMAP-Rule MF_01219 Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes By similarity. HAMAP-Rule MF_01219
Catalytic activity	UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP-Rule MF_01219 SAAS SAAS023050
Subunit structure	Homodimer and homohexamer; in equilibrium By similarity. HAMAP-Rule MF_01219
Sequence similarities	Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily. HAMAP-Rule MF_01219

Ontologies

Keywords
Biological process	Transcription Transcription regulation Transcription termination HAMAP-Rule MF_01219
Ligand	RNA-binding HAMAP-Rule MF_01219
Molecular function	Glycosyltransferase HAMAP-Rule MF_01219 SAAS SAAS023050 EMBL ACT02495.1 Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	DNA-dependent transcription, termination Inferred from electronic annotation. Source: HAMAP nucleoside metabolic process Inferred from electronic annotation. Source: InterPro regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	RNA binding Inferred from electronic annotation. Source: HAMAP uracil phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Motif	107 – 119	13	PRPP-binding By similarity HAMAP-Rule MF_01219

Sequences

	Sequence		Length	Mass (Da)
	C6D530 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 80202698C9002072	FASTA	190	21,464
	10 20 30 40 50 60 MEEEHLVIMD ETAIRRALTR IAHEIVEKNK GIDNCVLIGI RTRGIYLARR IADRIQDIEG 70 80 90 100 110 120 KPVEVRELDI TSYRDDRKAA SVDTRVELAA VIGDLNGELF SAHDKKVILC DDVLFTGRTI 130 140 150 160 170 180 RAAMDALMDC GRPESIQLAV LVDRGHRELP IRPDYVGKNV PTSKQEQIDV SLTEIDLKDQ 190 VMIIHQRGQV

References

[1]

"Complete genome sequence of Paenibacillus sp. strain JDR-2." Chow V., Nong G., St John F.J., Rice J.D., Dickstein E., Chertkov O., Bruce D., Detter C., Brettin T., Han J., Woyke T., Pitluck S., Nolan M., Pati A., Martin J., Copeland A., Land M.L., Goodwin L. , Jones J.B., Ingram L.O., Shanmugam K.T., Preston J.F. Stand. Genomic Sci. 6:1-10(2012) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JDR-2.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001656 Genomic DNA. Translation: ACT02495.1.
RefSeq	YP_003012581.1. NC_012914.1.
3D structure databases
ProteinModelPortal	C6D530.
SMR	C6D530. Positions 7-183.
ModBase	Search...
Protein-protein interaction databases
STRING	324057.Pjdr2_3865.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACT02495; ACT02495; Pjdr2_3865.
GeneID	8126390.
KEGG	pjd:Pjdr2_3865.
PATRIC	22838265. VBIPaeSp118865_3846.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG2065.
HOGENOM	HOG000245770.
KO	K02825.
OMA	KNVPTAR.
ProtClustDB	CLSK2551238.
Enzyme and pathway databases
BioCyc	PSP324057:GH5H-3958-MONOMER.
Family and domain databases
HAMAP	MF_01219. PyrR.
InterPro	IPR000836. PRibTrfase_dom. IPR023050. PyrR. [Graphical view]
Pfam	PF00156. Pribosyltran. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C6D530_PAESJ

Accession

Primary (citable) accession number: C6D530

Entry history

Integrated into UniProtKB/TrEMBL:	September 1, 2009
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)