Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation
Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferaseUniRule annotationSAAS annotationImported, RNA-bindingUniRule annotation, Transferase
Biological processTranscription, Transcription regulation, Transcription terminationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Including the following 2 domains:
Uracil phosphoribosyltransferaseUniRule annotation (EC:2.4.2.9UniRule annotation)
Short name:
UPRTaseUniRule annotation
Pyrimidine operon regulatory proteinUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:Pjdr2_3865Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Protein-protein interaction databases

STRINGi324057.Pjdr2_3865

Structurei

3D structure databases

ProteinModelPortaliC6D530
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini11 – 160PribosyltranInterPro annotationAdd BLAST150

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi107 – 119PRPP-bindingUniRule annotationAdd BLAST13

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4108UK1 Bacteria
COG2065 LUCA
HOGENOMiHOG000245770
KOiK02825
OMAiRISHEIL
OrthoDBiPOG091H02JM

Family and domain databases

CDDicd06223 PRTases_typeI, 1 hit
HAMAPiMF_01219 PyrR, 1 hit
InterProiView protein in InterPro
IPR000836 PRibTrfase_dom
IPR029057 PRTase-like
IPR023050 PyrR
PfamiView protein in Pfam
PF00156 Pribosyltran, 1 hit
SUPFAMiSSF53271 SSF53271, 1 hit

Sequencei

Sequence statusi: Complete.

C6D530-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEEEHLVIMD ETAIRRALTR IAHEIVEKNK GIDNCVLIGI RTRGIYLARR
60 70 80 90 100
IADRIQDIEG KPVEVRELDI TSYRDDRKAA SVDTRVELAA VIGDLNGELF
110 120 130 140 150
SAHDKKVILC DDVLFTGRTI RAAMDALMDC GRPESIQLAV LVDRGHRELP
160 170 180 190
IRPDYVGKNV PTSKQEQIDV SLTEIDLKDQ VMIIHQRGQV
Length:190
Mass (Da):21,464
Last modified:September 1, 2009 - v1
Checksum:i80202698C9002072
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA Translation: ACT02495.1

Genome annotation databases

EnsemblBacteriaiACT02495; ACT02495; Pjdr2_3865
KEGGipjd:Pjdr2_3865

Entry informationi

Entry nameiC6D530_PAESJ
AccessioniPrimary (citable) accession number: C6D530
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health