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C6D530

- C6D530_PAESJ

UniProt

C6D530 - C6D530_PAESJ

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Protein

Bifunctional protein PyrR

Gene

pyrR

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.UniRule annotation
Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes.UniRule annotation

Catalytic activityi

UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotationSAAS annotation

GO - Molecular functioni

  1. RNA binding Source: UniProtKB-HAMAP
  2. uracil phosphoribosyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA-templated transcription, termination Source: UniProtKB-HAMAP
  2. nucleoside metabolic process Source: InterPro
  3. regulation of transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

GlycosyltransferaseUniRule annotationSAAS annotation, Transferase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription terminationUniRule annotation

Keywords - Ligandi

RNA-bindingUniRule annotation

Enzyme and pathway databases

BioCyciPSP324057:GH5H-3958-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bifunctional protein PyrRUniRule annotation
Gene namesi
Name:pyrRUniRule annotation
Ordered Locus Names:Pjdr2_3865Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002510: Chromosome

Interactioni

Subunit structurei

Homodimer and homohexamer; in equilibrium.UniRule annotation

Protein-protein interaction databases

STRINGi324057.Pjdr2_3865.

Structurei

3D structure databases

ProteinModelPortaliC6D530.
SMRiC6D530. Positions 7-183.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi107 – 11913PRPP-bindingUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG2065.
HOGENOMiHOG000245770.
KOiK02825.
OMAiLMDMGRP.
OrthoDBiEOG61VZD8.

Family and domain databases

Gene3Di3.40.50.2020. 1 hit.
HAMAPiMF_01219. PyrR.
InterProiIPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view]
PfamiPF00156. Pribosyltran. 1 hit.
[Graphical view]
SUPFAMiSSF53271. SSF53271. 1 hit.

Sequencei

Sequence statusi: Complete.

C6D530-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEEEHLVIMD ETAIRRALTR IAHEIVEKNK GIDNCVLIGI RTRGIYLARR
60 70 80 90 100
IADRIQDIEG KPVEVRELDI TSYRDDRKAA SVDTRVELAA VIGDLNGELF
110 120 130 140 150
SAHDKKVILC DDVLFTGRTI RAAMDALMDC GRPESIQLAV LVDRGHRELP
160 170 180 190
IRPDYVGKNV PTSKQEQIDV SLTEIDLKDQ VMIIHQRGQV
Length:190
Mass (Da):21,464
Last modified:September 1, 2009 - v1
Checksum:i80202698C9002072
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001656 Genomic DNA. Translation: ACT02495.1.
RefSeqiWP_015845435.1. NC_012914.1.
YP_003012581.1. NC_012914.1.

Genome annotation databases

EnsemblBacteriaiACT02495; ACT02495; Pjdr2_3865.
GeneIDi8126390.
KEGGipjd:Pjdr2_3865.
PATRICi22838265. VBIPaeSp118865_3846.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001656 Genomic DNA. Translation: ACT02495.1 .
RefSeqi WP_015845435.1. NC_012914.1.
YP_003012581.1. NC_012914.1.

3D structure databases

ProteinModelPortali C6D530.
SMRi C6D530. Positions 7-183.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324057.Pjdr2_3865.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT02495 ; ACT02495 ; Pjdr2_3865 .
GeneIDi 8126390.
KEGGi pjd:Pjdr2_3865.
PATRICi 22838265. VBIPaeSp118865_3846.

Phylogenomic databases

eggNOGi COG2065.
HOGENOMi HOG000245770.
KOi K02825.
OMAi LMDMGRP.
OrthoDBi EOG61VZD8.

Enzyme and pathway databases

BioCyci PSP324057:GH5H-3958-MONOMER.

Family and domain databases

Gene3Di 3.40.50.2020. 1 hit.
HAMAPi MF_01219. PyrR.
InterProi IPR000836. PRibTrfase_dom.
IPR029057. PRTase-like.
IPR023050. PyrR.
[Graphical view ]
Pfami PF00156. Pribosyltran. 1 hit.
[Graphical view ]
SUPFAMi SSF53271. SSF53271. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JDR-2Imported.

Entry informationi

Entry nameiC6D530_PAESJ
AccessioniPrimary (citable) accession number: C6D530
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3