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C6D525

- C6D525_PAESJ

UniProt

C6D525 - C6D525_PAESJ

Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 39 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotationSAAS annotation

    Catalytic activityi

    Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei17 – 171SubstrateUniRule annotation
    Binding sitei39 – 391SubstrateUniRule annotation
    Active sitei68 – 681Proton donorUniRule annotation
    Binding sitei129 – 1291SubstrateUniRule annotation
    Binding sitei191 – 1911SubstrateUniRule annotation
    Binding sitei200 – 2001SubstrateUniRule annotation
    Binding sitei220 – 2201Substrate; via amide nitrogenUniRule annotation
    Binding sitei221 – 2211SubstrateUniRule annotation

    GO - Molecular functioni

    1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
    2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    DecarboxylaseUniRule annotation, Lyase

    Keywords - Biological processi

    Pyrimidine biosynthesisUniRule annotation

    Enzyme and pathway databases

    BioCyciPSP324057:GH5H-3953-MONOMER.
    UniPathwayiUPA00070; UER00120.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
    Alternative name(s):
    OMP decarboxylaseUniRule annotation
    Gene namesi
    Name:pyrFUniRule annotation
    Ordered Locus Names:Pjdr2_3860Imported
    OrganismiPaenibacillus sp. (strain JDR-2)Imported
    Taxonomic identifieri324057 [NCBI]
    Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
    ProteomesiUP000002510: Chromosome

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotationSAAS annotation

    Protein-protein interaction databases

    STRINGi324057.Pjdr2_3860.

    Structurei

    3D structure databases

    ProteinModelPortaliC6D525.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni66 – 7510Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0284.
    HOGENOMiHOG000226071.
    KOiK01591.
    OMAiSAYHAIK.
    OrthoDBiEOG6N6815.

    Family and domain databases

    Gene3Di3.20.20.70. 1 hit.
    HAMAPiMF_01200_B. OMPdecase_type1_B.
    InterProiIPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00215. OMPdecase. 1 hit.
    [Graphical view]
    SMARTiSM00934. OMPdecase. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 1 hit.
    TIGRFAMsiTIGR01740. pyrF. 1 hit.
    PROSITEiPS00156. OMPDECASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6D525-1 [UniParc]FASTAAdd to Basket

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    MSLTREQAAG KVMVALDYAD AASAKRLLSE LEGIPCYMKV GMQLFYAAGP    50
    SFVEELKKRG YRVFLDVKMH DIPNTVKGGS NSVTKLGVDM FNVHAAGGAA 100
    MMEAAVEGAE AALASGQARP AIIAVTQLTS TNVQVLNEEI GIAGSVEQAV 150
    VRYAELAKRA GLNGVVASPL EVDVIKSACG TSFQTVTPGI RPTWAATNDQ 200
    SRIMTPREAL EQGTDYMVIG RPITAAASPR EALESIIEEL I 241
    Length:241
    Mass (Da):25,487
    Last modified:September 1, 2009 - v1
    Checksum:i741E997CE6A198B7
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001656 Genomic DNA. Translation: ACT02490.1.
    RefSeqiWP_015845430.1. NC_012914.1.
    YP_003012576.1. NC_012914.1.

    Genome annotation databases

    EnsemblBacteriaiACT02490; ACT02490; Pjdr2_3860.
    GeneIDi8126385.
    KEGGipjd:Pjdr2_3860.
    PATRICi22838255. VBIPaeSp118865_3841.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001656 Genomic DNA. Translation: ACT02490.1 .
    RefSeqi WP_015845430.1. NC_012914.1.
    YP_003012576.1. NC_012914.1.

    3D structure databases

    ProteinModelPortali C6D525.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 324057.Pjdr2_3860.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT02490 ; ACT02490 ; Pjdr2_3860 .
    GeneIDi 8126385.
    KEGGi pjd:Pjdr2_3860.
    PATRICi 22838255. VBIPaeSp118865_3841.

    Phylogenomic databases

    eggNOGi COG0284.
    HOGENOMi HOG000226071.
    KOi K01591.
    OMAi SAYHAIK.
    OrthoDBi EOG6N6815.

    Enzyme and pathway databases

    UniPathwayi UPA00070 ; UER00120 .
    BioCyci PSP324057:GH5H-3953-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 1 hit.
    HAMAPi MF_01200_B. OMPdecase_type1_B.
    InterProi IPR013785. Aldolase_TIM.
    IPR014732. OMPdecase.
    IPR018089. OMPdecase_AS.
    IPR001754. OMPdeCOase_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00215. OMPdecase. 1 hit.
    [Graphical view ]
    SMARTi SM00934. OMPdecase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 1 hit.
    TIGRFAMsi TIGR01740. pyrF. 1 hit.
    PROSITEi PS00156. OMPDECASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: JDR-2Imported.

    Entry informationi

    Entry nameiC6D525_PAESJ
    AccessioniPrimary (citable) accession number: C6D525
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 39 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3