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C6D525 (C6D525_PAESJ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 37. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200

EC=4.1.1.23 HAMAP-Rule MF_01200
Alternative name(s):
OMP decarboxylase HAMAP-Rule MF_01200
Gene names
Name:pyrF HAMAP-Rule MF_01200
Ordered Locus Names:Pjdr2_3860 EMBL ACT02490.1
OrganismPaenibacillus sp. (strain JDR-2) [Complete proteome] [HAMAP] EMBL ACT02490.1
Taxonomic identifier324057 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus

Protein attributes

Sequence length241 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. SAAS SAAS001754 HAMAP-Rule MF_01200

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200 SAAS SAAS001754

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily. HAMAP-Rule MF_01200

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region66 – 7510Substrate binding By similarity HAMAP-Rule MF_01200

Sites

Active site681Proton donor By similarity HAMAP-Rule MF_01200
Binding site171Substrate By similarity HAMAP-Rule MF_01200
Binding site391Substrate By similarity HAMAP-Rule MF_01200
Binding site1291Substrate By similarity HAMAP-Rule MF_01200
Binding site1911Substrate By similarity HAMAP-Rule MF_01200
Binding site2001Substrate By similarity HAMAP-Rule MF_01200
Binding site2201Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01200
Binding site2211Substrate By similarity HAMAP-Rule MF_01200

Sequences

Sequence LengthMass (Da)Tools
C6D525 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 741E997CE6A198B7

FASTA24125,487
        10         20         30         40         50         60 
MSLTREQAAG KVMVALDYAD AASAKRLLSE LEGIPCYMKV GMQLFYAAGP SFVEELKKRG 

        70         80         90        100        110        120 
YRVFLDVKMH DIPNTVKGGS NSVTKLGVDM FNVHAAGGAA MMEAAVEGAE AALASGQARP 

       130        140        150        160        170        180 
AIIAVTQLTS TNVQVLNEEI GIAGSVEQAV VRYAELAKRA GLNGVVASPL EVDVIKSACG 

       190        200        210        220        230        240 
TSFQTVTPGI RPTWAATNDQ SRIMTPREAL EQGTDYMVIG RPITAAASPR EALESIIEEL 


I 

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References

[1]"Complete genome sequence of Paenibacillus sp. strain JDR-2."
Chow V., Nong G., St John F.J., Rice J.D., Dickstein E., Chertkov O., Bruce D., Detter C., Brettin T., Han J., Woyke T., Pitluck S., Nolan M., Pati A., Martin J., Copeland A., Land M.L., Goodwin L. expand/collapse author list , Jones J.B., Ingram L.O., Shanmugam K.T., Preston J.F.
Stand. Genomic Sci. 6:1-10(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JDR-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001656 Genomic DNA. Translation: ACT02490.1.
RefSeqYP_003012576.1. NC_012914.1.

3D structure databases

ProteinModelPortalC6D525.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324057.Pjdr2_3860.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT02490; ACT02490; Pjdr2_3860.
GeneID8126385.
KEGGpjd:Pjdr2_3860.
PATRIC22838255. VBIPaeSp118865_3841.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226071.
KOK01591.
OMASAYHAIK.
OrthoDBEOG6N6815.

Enzyme and pathway databases

BioCycPSP324057:GH5H-3953-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. SSF51366. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6D525_PAESJ
AccessionPrimary (citable) accession number: C6D525
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)