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C6D525

- C6D525_PAESJ

UniProt

C6D525 - C6D525_PAESJ

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Protein

Orotidine 5'-phosphate decarboxylase

Gene

pyrF

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).UniRule annotationSAAS annotation

Catalytic activityi

Orotidine 5'-phosphate = UMP + CO2.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei17 – 171SubstrateUniRule annotation
Binding sitei39 – 391SubstrateUniRule annotation
Active sitei68 – 681Proton donorUniRule annotation
Binding sitei129 – 1291SubstrateUniRule annotation
Binding sitei191 – 1911SubstrateUniRule annotation
Binding sitei200 – 2001SubstrateUniRule annotation
Binding sitei220 – 2201Substrate; via amide nitrogenUniRule annotation
Binding sitei221 – 2211SubstrateUniRule annotation

GO - Molecular functioni

  1. orotidine-5'-phosphate decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. 'de novo' pyrimidine nucleobase biosynthetic process Source: InterPro
  2. 'de novo' UMP biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

DecarboxylaseUniRule annotation, Lyase

Keywords - Biological processi

Pyrimidine biosynthesisUniRule annotation

Enzyme and pathway databases

BioCyciPSP324057:GH5H-3953-MONOMER.
UniPathwayiUPA00070; UER00120.

Names & Taxonomyi

Protein namesi
Recommended name:
Orotidine 5'-phosphate decarboxylaseUniRule annotation (EC:4.1.1.23UniRule annotation)
Alternative name(s):
OMP decarboxylaseUniRule annotation
Gene namesi
Name:pyrFUniRule annotation
Ordered Locus Names:Pjdr2_3860Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
ProteomesiUP000002510: Chromosome

Interactioni

Subunit structurei

Homodimer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi324057.Pjdr2_3860.

Structurei

3D structure databases

ProteinModelPortaliC6D525.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni66 – 7510Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the OMP decarboxylase family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0284.
HOGENOMiHOG000226071.
KOiK01591.
OMAiSAYHAIK.
OrthoDBiEOG6N6815.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_01200_B. OMPdecase_type1_B.
InterProiIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTiSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.
TIGRFAMsiTIGR01740. pyrF. 1 hit.
PROSITEiPS00156. OMPDECASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6D525-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLTREQAAG KVMVALDYAD AASAKRLLSE LEGIPCYMKV GMQLFYAAGP
60 70 80 90 100
SFVEELKKRG YRVFLDVKMH DIPNTVKGGS NSVTKLGVDM FNVHAAGGAA
110 120 130 140 150
MMEAAVEGAE AALASGQARP AIIAVTQLTS TNVQVLNEEI GIAGSVEQAV
160 170 180 190 200
VRYAELAKRA GLNGVVASPL EVDVIKSACG TSFQTVTPGI RPTWAATNDQ
210 220 230 240
SRIMTPREAL EQGTDYMVIG RPITAAASPR EALESIIEEL I
Length:241
Mass (Da):25,487
Last modified:September 1, 2009 - v1
Checksum:i741E997CE6A198B7
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001656 Genomic DNA. Translation: ACT02490.1.
RefSeqiWP_015845430.1. NC_012914.1.
YP_003012576.1. NC_012914.1.

Genome annotation databases

EnsemblBacteriaiACT02490; ACT02490; Pjdr2_3860.
GeneIDi8126385.
KEGGipjd:Pjdr2_3860.
PATRICi22838255. VBIPaeSp118865_3841.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001656 Genomic DNA. Translation: ACT02490.1 .
RefSeqi WP_015845430.1. NC_012914.1.
YP_003012576.1. NC_012914.1.

3D structure databases

ProteinModelPortali C6D525.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 324057.Pjdr2_3860.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT02490 ; ACT02490 ; Pjdr2_3860 .
GeneIDi 8126385.
KEGGi pjd:Pjdr2_3860.
PATRICi 22838255. VBIPaeSp118865_3841.

Phylogenomic databases

eggNOGi COG0284.
HOGENOMi HOG000226071.
KOi K01591.
OMAi SAYHAIK.
OrthoDBi EOG6N6815.

Enzyme and pathway databases

UniPathwayi UPA00070 ; UER00120 .
BioCyci PSP324057:GH5H-3953-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_01200_B. OMPdecase_type1_B.
InterProi IPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00215. OMPdecase. 1 hit.
[Graphical view ]
SMARTi SM00934. OMPdecase. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
TIGRFAMsi TIGR01740. pyrF. 1 hit.
PROSITEi PS00156. OMPDECASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JDR-2Imported.

Entry informationi

Entry nameiC6D525_PAESJ
AccessioniPrimary (citable) accession number: C6D525
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3