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Protein

Phosphoadenosine phosphosulfate reductase

Gene

cysH

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Reduction of activated sulfate into sulfite.UniRule annotationSAAS annotation

Catalytic activityi

Adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenylyl sulfate + thioredoxin.UniRule annotation

Pathwayi: hydrogen sulfide biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes sulfite from sulfate.UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. Sulfate adenylyltransferase subunit 2 (cysD), Sulfate adenylyltransferase subunit 1 (Pjdr2_4239)
  2. Adenylyl-sulfate kinase (cysC)
  3. Phosphoadenosine phosphosulfate reductase (cysH)
This subpathway is part of the pathway hydrogen sulfide biosynthesis, which is itself part of Sulfur metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sulfite from sulfate, the pathway hydrogen sulfide biosynthesis and in Sulfur metabolism.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductaseUniRule annotationSAAS annotationImported

Enzyme and pathway databases

UniPathwayiUPA00140; UER00206.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoadenosine phosphosulfate reductaseUniRule annotation (EC:1.8.4.8UniRule annotation)
Alternative name(s):
3'-phosphoadenylylsulfate reductaseUniRule annotation
PAPS reductase, thioredoxin dependentUniRule annotation
PAPS sulfotransferaseUniRule annotation
PAdoPS reductaseUniRule annotation
Gene namesi
Name:cysHUniRule annotation
Ordered Locus Names:Pjdr2_5647Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002510 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi324057.Pjdr2_5647.

Structurei

3D structure databases

ProteinModelPortaliC6D4K6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 206PAPS_reductInterPro annotationAdd BLAST171

Sequence similaritiesi

Belongs to the PAPS reductase family. CysH subfamily.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105ET3. Bacteria.
COG0175. LUCA.
HOGENOMiHOG000249397.
KOiK00390.
OMAiKFGLVKF.
OrthoDBiPOG091H04I4.

Family and domain databases

CDDicd01713. PAPS_reductase. 1 hit.
Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00063. CysH. 1 hit.
InterProiView protein in InterPro
IPR011798. APS_reductase.
IPR004511. PAPS/APS_Rdtase.
IPR002500. PAPS_reduct.
IPR014729. Rossmann-like_a/b/a_fold.
PfamiView protein in Pfam
PF01507. PAPS_reduct. 1 hit.
PIRSFiPIRSF000857. PAPS_reductase. 1 hit.
TIGRFAMsiTIGR02055. APS_reductase. 1 hit.
TIGR00434. cysH. 1 hit.

Sequencei

Sequence statusi: Complete.

C6D4K6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNLFEKEALV KQKAEELENA TPQEILAYAV EAFPNITFAC SFGAEDVVLV
60 70 80 90 100
DMLQKVSPKT DIFYLDTDFH FKETYETRDR MVERYPGIPF VEVKPLITPE
110 120 130 140 150
EQAERHGAEL WKSDANACCN IRKVEPLTRI LSKYDAWITG IRRDQAPTRA
160 170 180 190 200
NAKKVEYDTK FGLIKFNPIA GWTTEDVWNY IRENDVIYNP LHDQNYPSIG
210 220 230
CEYCTRQVMP GEDPRAGRWS GQEKTECGLH K
Length:231
Mass (Da):26,678
Last modified:September 1, 2009 - v1
Checksum:iF195E5BE8C281FE9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA. Translation: ACT04254.1.
RefSeqiWP_015847192.1. NC_012914.1.

Genome annotation databases

EnsemblBacteriaiACT04254; ACT04254; Pjdr2_5647.
KEGGipjd:Pjdr2_5647.

Similar proteinsi

Entry informationi

Entry nameiC6D4K6_PAESJ
AccessioniPrimary (citable) accession number: C6D4K6
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: September 27, 2017
This is version 64 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported