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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

Pjdr2_3757

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Type III pantothenate kinase (coaX)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (Pjdr2_3757)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (Pjdr2_3757)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotationImported, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

BioCyciPSP324057:GH5H-3796-MONOMER.
UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
Ordered Locus Names:Pjdr2_3757Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002510 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi324057.Pjdr2_3757.

Structurei

3D structure databases

ProteinModelPortaliC6D4F9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 175FlavoproteinInterPro annotationAdd BLAST171
Domaini187 – 368DFPInterPro annotationAdd BLAST182

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJS. Bacteria.
COG0452. LUCA.
HOGENOMiHOG000037525.
KOiK13038.
OMAiVRFIGNH.
OrthoDBiPOG091H021V.

Family and domain databases

Gene3Di3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR035929. CoaB-like_sf.
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR036551. Flavin_trans-like.
IPR003382. Flavoprotein.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

C6D4F9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLRGKTIVLG ITGGIAAYKG AALCSKLVQA GAEVHVIMTE SATKFITPLT
60 70 80 90 100
LQTLSRHPVH IDTFDEKDPS VVTHIDLADR ADLVVIAPAT ANIIGKVANG
110 120 130 140 150
LADDMLSTTL LAATSPVLVA PAMNVHMYEH PAVVRNLELL ASRGVMFVEP
160 170 180 190 200
GTGQLACGYV AKGRLAEPED IVIAVHSLLK AKEHGTLAGK RVLVTAGGTM
210 220 230 240 250
ERLDPVRYLT NDSSGKMGFA IAEAAKVMGA EVTVIAGRTS VDPPAGVKVI
260 270 280 290 300
RVESARQMLD AVLERFEESD IVVKSAAVAD YRPVTRHGQK IKKSGETLTL
310 320 330 340 350
ELEKTTDILQ TLGERKTHQL LIGFAAETEQ LEKYAMDKLK RKNADLIVGN
360 370 380 390 400
DVSQEGAGFN GDTNIVQLYG PSGLIEAMPL LSKRETAQRI LTIAARRLSE
410
GAAQSGGRGE E
Length:411
Mass (Da):43,755
Last modified:September 1, 2009 - v1
Checksum:iC22358B80D7CC144
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA. Translation: ACT02387.1.
RefSeqiWP_015845328.1. NC_012914.1.

Genome annotation databases

EnsemblBacteriaiACT02387; ACT02387; Pjdr2_3757.
KEGGipjd:Pjdr2_3757.

Similar proteinsi

Entry informationi

Entry nameiC6D4F9_PAESJ
AccessioniPrimary (citable) accession number: C6D4F9
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: October 25, 2017
This is version 49 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported