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C6CUX8 (C6CUX8_PAESJ) Unreviewed, UniProtKB/TrEMBL

Last modified June 11, 2014. Version 34. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
D-alanine--D-alanine ligase HAMAP-Rule MF_00047

EC=6.3.2.4 HAMAP-Rule MF_00047
Alternative name(s):
D-Ala-D-Ala ligase HAMAP-Rule MF_00047
D-alanylalanine synthetase HAMAP-Rule MF_00047
Gene names
Name:ddl HAMAP-Rule MF_00047
Ordered Locus Names:Pjdr2_0813 EMBL ACS99492.1
OrganismPaenibacillus sp. (strain JDR-2) [Complete proteome] [HAMAP] EMBL ACS99492.1
Taxonomic identifier324057 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus

Protein attributes

Sequence length375 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Cell wall formation By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Catalytic activity

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP-Rule MF_00047 SAAS SAAS011095

Cofactor

Binds 2 magnesium or manganese ions per subunit By similarity. HAMAP-Rule MF_00047 SAAS SAAS011095

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP-Rule MF_00047 SAAS SAAS011095

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00047 SAAS SAAS011095.

Sequence similarities

Belongs to the D-alanine--D-alanine ligase family. HAMAP-Rule MF_00047

Contains 1 ATP-grasp domain. HAMAP-Rule MF_00047

Contains ATP-grasp domain. SAAS SAAS011095

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Domain149 – 355207ATP-grasp By similarity HAMAP-Rule MF_00047
Nucleotide binding182 – 23756ATP By similarity HAMAP-Rule MF_00047

Sites

Metal binding3081Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3221Magnesium or manganese 1 By similarity HAMAP-Rule MF_00047
Metal binding3221Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047
Metal binding3241Magnesium or manganese 2 By similarity HAMAP-Rule MF_00047

Sequences

Sequence LengthMass (Da)Tools
C6CUX8 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: C892D71ED1C17AED

FASTA37541,021
        10         20         30         40         50         60 
MGQKVHLGLI YGGKSGEHDV SLRTAFAVMG ELDYAKYEIT PFYITRLGEW RVGSMLGGQP 

        70         80         90        100        110        120 
GAIDELRLAP VDGAPVPIVP DLPLAPLLDR LAGGALPGGG QPIDVVFPLL HGTFGEDGTI 

       130        140        150        160        170        180 
QGLLEIADIP YVGAGVLASA AGMDKITMKK IFAYEGLPQC VFRYFNRAQW EKDASFFIME 

       190        200        210        220        230        240 
CEVALGYPCF VKPSNLGSSV GISKAKNRDE LIAAIDFAFR FDRRVIVEEF VDAREIEVSV 

       250        260        270        280        290        300 
LGNDDPKISV PGEIAPSNEF YDYKAKYVDG KSTIHIPANI PNKTADAVRD MALRAFLAID 

       310        320        330        340        350        360 
GAGLSRVDFF LRKTDGQLFI NEVNTMPGFT PISMYPLMWK ESGLPYKDLL DKLIDLAFKR 

       370 
YADRRTIDYG SSGGN 

« Hide

References

[1]"Complete genome sequence of Paenibacillus sp. strain JDR-2."
Chow V., Nong G., St John F.J., Rice J.D., Dickstein E., Chertkov O., Bruce D., Detter C., Brettin T., Han J., Woyke T., Pitluck S., Nolan M., Pati A., Martin J., Copeland A., Land M.L., Goodwin L. expand/collapse author list , Jones J.B., Ingram L.O., Shanmugam K.T., Preston J.F.
Stand. Genomic Sci. 6:1-10(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JDR-2.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001656 Genomic DNA. Translation: ACS99492.1.
RefSeqYP_003009579.1. NC_012914.1.

3D structure databases

ProteinModelPortalC6CUX8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING324057.Pjdr2_0813.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS99492; ACS99492; Pjdr2_0813.
GeneID8125793.
KEGGpjd:Pjdr2_0813.
PATRIC22832083. VBIPaeSp118865_0807.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1181.
HOGENOMHOG000011593.
KOK01921.
OMAQIDVIFP.
OrthoDBEOG64BQ73.

Enzyme and pathway databases

BioCycPSP324057:GH5H-854-MONOMER.
UniPathwayUPA00219.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPMF_00047. Dala_Dala_lig.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERPTHR23132. PTHR23132. 1 hit.
PfamPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMSSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6CUX8_PAESJ
AccessionPrimary (citable) accession number: C6CUX8
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)