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Protein

Beta sliding clamp

Gene

Pjdr2_0002

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-bindingSAAS annotation, DNA-directed DNA polymeraseUniRule annotationSAAS annotation, Nucleotidyltransferase, Transferase
Biological processDNA replicationUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciPSP324057:GH5H-2-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta sliding clampUniRule annotation
Gene namesi
Ordered Locus Names:Pjdr2_0002Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002510 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Forms a ring-shaped head-to-tail homodimer around DNA.UniRule annotation

Protein-protein interaction databases

STRINGi324057.Pjdr2_0002.

Structurei

3D structure databases

ProteinModelPortaliC6CSZ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 127DNA_pol3_betaInterPro annotationAdd BLAST127
Domaini137 – 252DNA_pol3_beta_2InterPro annotationAdd BLAST116
Domaini255 – 377DNA_pol3_beta_3InterPro annotationAdd BLAST123

Sequence similaritiesi

Belongs to the beta sliding clamp family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CZ8. Bacteria.
COG0592. LUCA.
HOGENOMiHOG000071792.
KOiK02338.
OMAiNYEAVIP.
OrthoDBiPOG091H02B3.

Family and domain databases

CDDicd00140. beta_clamp. 1 hit.
InterProiView protein in InterPro
IPR001001. DNA_polIII_beta.
IPR022635. DNA_polIII_beta_C.
IPR022637. DNA_polIII_beta_cen.
IPR022634. DNA_polIII_beta_N.
PANTHERiPTHR30478. PTHR30478. 1 hit.
PfamiView protein in Pfam
PF00712. DNA_pol3_beta. 1 hit.
PF02767. DNA_pol3_beta_2. 1 hit.
PF02768. DNA_pol3_beta_3. 1 hit.
PIRSFiPIRSF000804. DNA_pol_III_b. 1 hit.
SMARTiView protein in SMART
SM00480. POL3Bc. 1 hit.
TIGRFAMsiTIGR00663. dnan. 1 hit.

Sequencei

Sequence statusi: Complete.

C6CSZ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLSISKHEL NEAIQQVAKA ASSRPTIPIL GGIKIEVTHQ GVTLTASDTD
60 70 80 90 100
ISIQSFIPVE RDDLVIANVD KPGNVVLPAK FFVEIVKKLP SDNVEIEVGA
110 120 130 140 150
HFQTLIRSGS TDIQMVGLDP EEFPVLPSIE QNELFQMPGD LLKAMIRQTV
160 170 180 190 200
LAASVNEQTP ILTGVLWSLQ DKQLKFVATD RHRLASRIAQ AETAADYRFN
210 220 230 240 250
NVVIAAKTLV ELSKLVPDQH GLVDIVVADN QVLFKIGNVL FYTRVLDGTY
260 270 280 290 300
PDTSKIIPSV FKTELVLDTK KLTDAIDRAY LMSREEKTNI VRLATMEDGS
310 320 330 340 350
IEISSSSTEL GRVTEQLEPK QFDGEPLKIA FNSKYMLDVL KVIDSEHIFI
360 370 380
GFTGAMSPIV IRPTDHSYNT YVILPYRTTN
Length:380
Mass (Da):42,147
Last modified:September 1, 2009 - v1
Checksum:i80AA5D725055C77C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA. Translation: ACS98682.1.
RefSeqiWP_012772004.1. NC_012914.1.

Genome annotation databases

EnsemblBacteriaiACS98682; ACS98682; Pjdr2_0002.
KEGGipjd:Pjdr2_0002.

Similar proteinsi

Entry informationi

Entry nameiC6CSZ8_PAESJ
AccessioniPrimary (citable) accession number: C6CSZ8
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: January 31, 2018
This is version 60 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported