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Protein

Transcription termination factor Rho

Gene

rho

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei210ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 172ATPUniRule annotation6
Nucleotide bindingi179 – 184ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicaseUniRule annotation, Hydrolase, RNA-bindingUniRule annotation
Biological processTranscription, Transcription regulation, Transcription terminationUniRule annotation
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciPSP324057:G1GF7-149-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:Pjdr2_0140Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002510 Componenti: Chromosome

PTM / Processingi

Proteomic databases

PRIDEiC6CST1

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Protein-protein interaction databases

STRINGi324057.Pjdr2_0140

Structurei

3D structure databases

ProteinModelPortaliC6CST1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 50Rho_NInterPro annotationAdd BLAST43
Domaini55 – 119CSPInterPro annotationAdd BLAST65
Domaini168 – 353AAAInterPro annotationAdd BLAST186

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4P Bacteria
COG1158 LUCA
HOGENOMiHOG000076952
KOiK03628
OMAiDYNYLPG
OrthoDBiPOG091H05EO

Family and domain databases

CDDicd04459 Rho_CSD, 1 hit
HAMAPiMF_01884 Rho, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR000194 ATPase_F1/V1/A1_a/bsu_nucl-bd
IPR011129 CSD
IPR012340 NA-bd_OB-fold
IPR027417 P-loop_NTPase
IPR011112 Rho_N
IPR036269 Rho_N_sf
IPR011113 Rho_RNA-bd
IPR004665 Term_rho
PANTHERiPTHR15184:SF34 PTHR15184:SF34, 1 hit
PfamiView protein in Pfam
PF00006 ATP-synt_ab, 1 hit
PF07498 Rho_N, 1 hit
PF07497 Rho_RNA_bind, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SM00357 CSP, 1 hit
SM00959 Rho_N, 1 hit
SUPFAMiSSF50249 SSF50249, 1 hit
SSF52540 SSF52540, 1 hit
SSF68912 SSF68912, 1 hit
TIGRFAMsiTIGR00767 rho, 1 hit

Sequencei

Sequence statusi: Complete.

C6CST1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLQISDLE EMKLTELYKL AKQYQIPYYG QLKKKELIFA ILRAQAEKSG
60 70 80 90 100
LMFMQGVLET LPEGFGFLRP INYLPSKEDI YISASQIRKF DLRTGDLVSG
110 120 130 140 150
KCRLPKDSEK YFGLLQVNAV NGTDPAQAAE RLHFPALTPL YPQKKLVLET
160 170 180 190 200
ASSKLSTRIM DLLAPVGLGQ RGLIVAPPKA GKTLLLKEIA NSISTNHPDI
210 220 230 240 250
ELFVLLIDER PEEVTDMQRS VKGEVIASTF DEVPENHIKV AELVLERALR
260 270 280 290 300
LVEHKKDVVI LLDSITRLAR AYNLVVPPSG RTLSGGIDPA AFHRPKRFFG
310 320 330 340 350
AARNVEEGGS LTILATALIE TGSRMDDIIY EEFKGTGNME LHLDRKLAER
360 370 380 390 400
RIFPALDIRR SGTRREEMLL SKEELDKLWV VRRNMTDTPD FVDGFLKKLA
410 420 430 440
DSKTNEEFLM SLDTSEEKPA PQQRTSTGTG LKSSAATGRR PAPRTTHGS
Length:449
Mass (Da):50,231
Last modified:September 1, 2009 - v1
Checksum:i335223FC9B79B657
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA Translation: ACS98820.1
RefSeqiWP_012772142.1, NC_012914.1

Genome annotation databases

EnsemblBacteriaiACS98820; ACS98820; Pjdr2_0140
KEGGipjd:Pjdr2_0140

Similar proteinsi

Entry informationi

Entry nameiC6CST1_PAESJ
AccessioniPrimary (citable) accession number: C6CST1
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 70 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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