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Protein

Transcription termination factor Rho

Gene

rho

Organism
Paenibacillus sp. (strain JDR-2)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei210ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi167 – 172ATPUniRule annotation6
Nucleotide bindingi179 – 184ATPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

HelicaseUniRule annotation, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation, Transcription terminationUniRule annotation

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription termination factor RhoUniRule annotation (EC:3.6.4.-UniRule annotation)
Alternative name(s):
ATP-dependent helicase RhoUniRule annotation
Gene namesi
Name:rhoUniRule annotation
Ordered Locus Names:Pjdr2_0140Imported
OrganismiPaenibacillus sp. (strain JDR-2)Imported
Taxonomic identifieri324057 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesPaenibacillaceaePaenibacillus
Proteomesi
  • UP000002510 Componenti: Chromosome

Interactioni

Subunit structurei

Homohexamer. The homohexamer assembles into an open ring structure.UniRule annotation

Protein-protein interaction databases

STRINGi324057.Pjdr2_0140.

Structurei

3D structure databases

ProteinModelPortaliC6CST1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 50Rho_NInterPro annotationAdd BLAST43
Domaini55 – 119CSPInterPro annotationAdd BLAST65
Domaini168 – 353AAAInterPro annotationAdd BLAST186

Sequence similaritiesi

Belongs to the Rho family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C4P. Bacteria.
COG1158. LUCA.
HOGENOMiHOG000076952.
KOiK03628.
OMAiFPQEKFN.
OrthoDBiPOG091H05EO.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.

Sequencei

Sequence statusi: Complete.

C6CST1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTDLQISDLE EMKLTELYKL AKQYQIPYYG QLKKKELIFA ILRAQAEKSG
60 70 80 90 100
LMFMQGVLET LPEGFGFLRP INYLPSKEDI YISASQIRKF DLRTGDLVSG
110 120 130 140 150
KCRLPKDSEK YFGLLQVNAV NGTDPAQAAE RLHFPALTPL YPQKKLVLET
160 170 180 190 200
ASSKLSTRIM DLLAPVGLGQ RGLIVAPPKA GKTLLLKEIA NSISTNHPDI
210 220 230 240 250
ELFVLLIDER PEEVTDMQRS VKGEVIASTF DEVPENHIKV AELVLERALR
260 270 280 290 300
LVEHKKDVVI LLDSITRLAR AYNLVVPPSG RTLSGGIDPA AFHRPKRFFG
310 320 330 340 350
AARNVEEGGS LTILATALIE TGSRMDDIIY EEFKGTGNME LHLDRKLAER
360 370 380 390 400
RIFPALDIRR SGTRREEMLL SKEELDKLWV VRRNMTDTPD FVDGFLKKLA
410 420 430 440
DSKTNEEFLM SLDTSEEKPA PQQRTSTGTG LKSSAATGRR PAPRTTHGS
Length:449
Mass (Da):50,231
Last modified:September 1, 2009 - v1
Checksum:i335223FC9B79B657
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA. Translation: ACS98820.1.
RefSeqiWP_012772142.1. NC_012914.1.

Genome annotation databases

EnsemblBacteriaiACS98820; ACS98820; Pjdr2_0140.
KEGGipjd:Pjdr2_0140.
PATRICi22830697. VBIPaeSp118865_0142.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001656 Genomic DNA. Translation: ACS98820.1.
RefSeqiWP_012772142.1. NC_012914.1.

3D structure databases

ProteinModelPortaliC6CST1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi324057.Pjdr2_0140.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS98820; ACS98820; Pjdr2_0140.
KEGGipjd:Pjdr2_0140.
PATRICi22830697. VBIPaeSp118865_0142.

Phylogenomic databases

eggNOGiENOG4105C4P. Bacteria.
COG1158. LUCA.
HOGENOMiHOG000076952.
KOiK03628.
OMAiFPQEKFN.
OrthoDBiPOG091H05EO.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_01884. Rho. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR000194. ATPase_F1/V1/A1_a/bsu_nucl-bd.
IPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR027417. P-loop_NTPase.
IPR011112. Rho_N.
IPR011113. Rho_RNA-bd.
IPR004665. Term_rho.
[Graphical view]
PfamiPF00006. ATP-synt_ab. 1 hit.
PF07498. Rho_N. 1 hit.
PF07497. Rho_RNA_bind. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
SM00357. CSP. 1 hit.
SM00959. Rho_N. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
SSF52540. SSF52540. 1 hit.
SSF68912. SSF68912. 1 hit.
TIGRFAMsiTIGR00767. rho. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiC6CST1_PAESJ
AccessioniPrimary (citable) accession number: C6CST1
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 2, 2016
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.