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C6CN33

- C6CN33_DICZE

UniProt

C6CN33 - C6CN33_DICZE

Protein

Beta-galactosidase

Gene

lacZ

Organism
Dickeya zeae (strain Ech1591)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 38 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

    Cofactori

    Binds 1 sodium ion per monomer.UniRule annotation
    Binds 2 magnesium ions per monomer.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei110 – 1101SubstrateUniRule annotation
    Metal bindingi209 – 2091SodiumUniRule annotation
    Binding sitei209 – 2091SubstrateUniRule annotation
    Sitei366 – 3661Transition state stabilizerUniRule annotation
    Sitei400 – 4001Transition state stabilizerUniRule annotation
    Metal bindingi425 – 4251Magnesium 1UniRule annotation
    Metal bindingi427 – 4271Magnesium 1UniRule annotation
    Active sitei470 – 4701Proton donorUniRule annotation
    Metal bindingi470 – 4701Magnesium 1UniRule annotation
    Binding sitei470 – 4701SubstrateUniRule annotation
    Active sitei546 – 5461NucleophileUniRule annotation
    Metal bindingi605 – 6051Magnesium 2UniRule annotation
    Metal bindingi609 – 6091Sodium; via carbonyl oxygenUniRule annotation
    Metal bindingi612 – 6121SodiumUniRule annotation
    Binding sitei612 – 6121SubstrateUniRule annotation
    Binding sitei1012 – 10121SubstrateUniRule annotation

    GO - Molecular functioni

    1. beta-galactosidase activity Source: UniProtKB-EC
    2. carbohydrate binding Source: InterPro
    3. magnesium ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbohydrate metabolic process Source: InterPro

    Keywords - Molecular functioni

    GlycosidaseUniRule annotationSAAS annotation, Hydrolase

    Keywords - Ligandi

    MagnesiumUniRule annotation, Metal-bindingUniRule annotation, SodiumUniRule annotation

    Enzyme and pathway databases

    BioCyciDZEA561229:GJ85-2791-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
    Short name:
    Beta-galUniRule annotation
    Alternative name(s):
    LactaseUniRule annotation
    Gene namesi
    Name:lacZUniRule annotation
    Ordered Locus Names:Dd1591_2733Imported
    OrganismiDickeya zeae (strain Ech1591)Imported
    Taxonomic identifieri561229 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
    ProteomesiUP000002735: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. beta-galactosidase complex Source: InterPro

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi561229.Dd1591_2733.

    Structurei

    3D structure databases

    ProteinModelPortaliC6CN33.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni546 – 5494Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the glycosyl hydrolase 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG3250.
    HOGENOMiHOG000252443.
    KOiK01190.
    OMAiNPPFVPK.
    OrthoDBiEOG6XWV0T.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPiMF_01687. Beta_gal.
    InterProiIPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view]
    PfamiPF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view]
    PRINTSiPR00132. GLHYDRLASE2.
    SMARTiSM01038. Bgal_small_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6CN33-1 [UniParc]FASTAAdd to Basket

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    MSTASAYAPL SGLSLADILA RRDWENPACP HIRRLDAHPP FSSWRNLNAA     50
    RDDQPSDRRQ MLNGEWTFSY FSRPEAVPEQ WLTQDLTDAN PLAVPSNWQL 100
    AGYDAPIYTN IKYPIPVNPP FVPQDNPTGC YSLTFSVNGD WLTQGQTRIV 150
    FDGVNSAFHL WCNGQWVGYS QDSRLPAEFD LTSCLQPGEN RLAVMVLRWS 200
    DGTYLEDQDM WRMSGIYRDV YLLHKPAVHL RDVQLTTPLR HSYTQGTLCV 250
    TALANLPEDQ AQAWQLAVQL WRGGQLVGEQ RAPFGTPAID ERGAYHDRVS 300
    LQLEVAQPAL WSAEEPNLYR AVVALEYDGT LVEAEAYDVG FREVAIRNGL 350
    LLLNGQPLLI RGTNRHEHHP QYGQAIDEAT MRQDILLMKQ HNFNAVRCSH 400
    YPNHPLWYRL CDRYGLYVVD EANIETHGMQ PMSRLSDDPR WLPAYAERVT 450
    RMVQRDRNHP CIIIWSLGNE SGYGPTHSAL YQWVKQQDPT RPVQYEGGGA 500
    DTPATDILCP MYARVDQDQP FPAVPKWSIK KWIGLPGEHR PLILCEYAHA 550
    MGNSFGGFDR YWQAFRQYPR LQGGFVWDWV DQALTREQDG KTHWAYGGDF 600
    GDKPNDRQFC LNGLVFPDRT PHPALYEAQR AQQFFQFNHH ENAPLTLTIT 650
    SEYLFRRSDN EELHWRIMQD DVQLASGRVP LDITPQGCQT LTLLEQLPAP 700
    QHHADMWLTV EVIQPNATDW SPAGHRCAWD QWQLPMPLAR PTPRRDGSER 750
    PTLTQNDDQF EVIHGQQRWA FNRHNGLLTQ WWRDGQAQLL SPLQDNLARA 800
    PLDNDIGISE VDRIDPNAWV ERWKLAGLYR YDTDCRHIHA DTLSDGVLIT 850
    TEHIGHYQQQ VLFISRKQWR IDAQGVLTVS VEVDVARHLP SLARVGLSMQ 900
    LAAVTPQVSW LGLGPHENYP DRRLAALHGR WQQPLEAMHT PYIFPSENGL 950
    RCHTRELRYG DWLIEGDFHF GIGRYSRQQL MDCTHHHLLQ PEPGTWLNLD 1000
    GFHMGIGGDD SWSPSVAPDF LLTAPRYRYQ LQLQLR 1036
    Length:1,036
    Mass (Da):118,909
    Last modified:September 1, 2009 - v1
    Checksum:iA8794CDE12419D1C
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001655 Genomic DNA. Translation: ACT07558.1.
    RefSeqiWP_012770413.1. NC_012912.1.
    YP_003005037.1. NC_012912.1.

    Genome annotation databases

    EnsemblBacteriaiACT07558; ACT07558; Dd1591_2733.
    GeneIDi8119175.
    KEGGidze:Dd1591_2733.
    PATRICi21801475. VBIDicZea111179_2781.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001655 Genomic DNA. Translation: ACT07558.1 .
    RefSeqi WP_012770413.1. NC_012912.1.
    YP_003005037.1. NC_012912.1.

    3D structure databases

    ProteinModelPortali C6CN33.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 561229.Dd1591_2733.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACT07558 ; ACT07558 ; Dd1591_2733 .
    GeneIDi 8119175.
    KEGGi dze:Dd1591_2733.
    PATRICi 21801475. VBIDicZea111179_2781.

    Phylogenomic databases

    eggNOGi COG3250.
    HOGENOMi HOG000252443.
    KOi K01190.
    OMAi NPPFVPK.
    OrthoDBi EOG6XWV0T.

    Enzyme and pathway databases

    BioCyci DZEA561229:GJ85-2791-MONOMER.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    2.60.40.320. 2 hits.
    2.70.98.10. 1 hit.
    3.20.20.80. 1 hit.
    HAMAPi MF_01687. Beta_gal.
    InterProi IPR004199. B-gal_small/dom_5.
    IPR011013. Gal_mutarotase_SF_dom.
    IPR008979. Galactose-bd-like.
    IPR014718. Glyco_hydro-type_carb-bd_sub.
    IPR006101. Glyco_hydro_2.
    IPR013812. Glyco_hydro_2/20_Ig-like.
    IPR023232. Glyco_hydro_2_AS.
    IPR023933. Glyco_hydro_2_beta_Galsidase.
    IPR023230. Glyco_hydro_2_CS.
    IPR006102. Glyco_hydro_2_Ig-like.
    IPR006104. Glyco_hydro_2_N.
    IPR006103. Glyco_hydro_2_TIM.
    IPR013781. Glyco_hydro_catalytic_dom.
    IPR017853. Glycoside_hydrolase_SF.
    [Graphical view ]
    Pfami PF02929. Bgal_small_N. 1 hit.
    PF00703. Glyco_hydro_2. 1 hit.
    PF02836. Glyco_hydro_2_C. 1 hit.
    PF02837. Glyco_hydro_2_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00132. GLHYDRLASE2.
    SMARTi SM01038. Bgal_small_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF49303. SSF49303. 2 hits.
    SSF49785. SSF49785. 1 hit.
    SSF51445. SSF51445. 1 hit.
    SSF74650. SSF74650. 1 hit.
    PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
    PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ech1591Imported.

    Entry informationi

    Entry nameiC6CN33_DICZE
    AccessioniPrimary (citable) accession number: C6CN33
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 38 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3