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C6CN33

- C6CN33_DICZE

UniProt

C6CN33 - C6CN33_DICZE

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Protein

Beta-galactosidase

Gene

lacZ

Organism
Dickeya zeae (strain Ech1591)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides.UniRule annotationSAAS annotation

Cofactori

Protein has several cofactor binding sites:
  • Note: Binds 1 sodium ion per monomer.UniRule annotation
  • Note: Binds 2 magnesium ions per monomer.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei110 – 1101SubstrateUniRule annotation
Metal bindingi209 – 2091SodiumUniRule annotation
Binding sitei209 – 2091SubstrateUniRule annotation
Sitei366 – 3661Transition state stabilizerUniRule annotation
Sitei400 – 4001Transition state stabilizerUniRule annotation
Metal bindingi425 – 4251Magnesium 1UniRule annotation
Metal bindingi427 – 4271Magnesium 1UniRule annotation
Active sitei470 – 4701Proton donorUniRule annotation
Metal bindingi470 – 4701Magnesium 1UniRule annotation
Binding sitei470 – 4701SubstrateUniRule annotation
Active sitei546 – 5461NucleophileUniRule annotation
Metal bindingi605 – 6051Magnesium 2UniRule annotation
Metal bindingi609 – 6091Sodium; via carbonyl oxygenUniRule annotation
Metal bindingi612 – 6121SodiumUniRule annotation
Binding sitei612 – 6121SubstrateUniRule annotation
Binding sitei1012 – 10121SubstrateUniRule annotation

GO - Molecular functioni

  1. beta-galactosidase activity Source: UniProtKB-EC
  2. carbohydrate binding Source: InterPro
  3. magnesium ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbohydrate metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

GlycosidaseUniRule annotationSAAS annotation, Hydrolase

Keywords - Ligandi

MagnesiumUniRule annotation, Metal-bindingUniRule annotation, SodiumUniRule annotation

Enzyme and pathway databases

BioCyciDZEA561229:GJ85-2791-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Beta-galactosidaseUniRule annotation (EC:3.2.1.23UniRule annotation)
Short name:
Beta-galUniRule annotation
Alternative name(s):
LactaseUniRule annotation
Gene namesi
Name:lacZUniRule annotation
Ordered Locus Names:Dd1591_2733Imported
OrganismiDickeya zeae (strain Ech1591)Imported
Taxonomic identifieri561229 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
ProteomesiUP000002735: Chromosome

Subcellular locationi

GO - Cellular componenti

  1. beta-galactosidase complex Source: InterPro
Complete GO annotation...

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi561229.Dd1591_2733.

Structurei

3D structure databases

ProteinModelPortaliC6CN33.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni546 – 5494Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the glycosyl hydrolase 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG3250.
HOGENOMiHOG000252443.
KOiK01190.
OMAiNPPFVPK.
OrthoDBiEOG6XWV0T.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPiMF_01687. Beta_gal.
InterProiIPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view]
PfamiPF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view]
PRINTSiPR00132. GLHYDRLASE2.
SMARTiSM01038. Bgal_small_N. 1 hit.
[Graphical view]
SUPFAMiSSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEiPS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6CN33-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSTASAYAPL SGLSLADILA RRDWENPACP HIRRLDAHPP FSSWRNLNAA
60 70 80 90 100
RDDQPSDRRQ MLNGEWTFSY FSRPEAVPEQ WLTQDLTDAN PLAVPSNWQL
110 120 130 140 150
AGYDAPIYTN IKYPIPVNPP FVPQDNPTGC YSLTFSVNGD WLTQGQTRIV
160 170 180 190 200
FDGVNSAFHL WCNGQWVGYS QDSRLPAEFD LTSCLQPGEN RLAVMVLRWS
210 220 230 240 250
DGTYLEDQDM WRMSGIYRDV YLLHKPAVHL RDVQLTTPLR HSYTQGTLCV
260 270 280 290 300
TALANLPEDQ AQAWQLAVQL WRGGQLVGEQ RAPFGTPAID ERGAYHDRVS
310 320 330 340 350
LQLEVAQPAL WSAEEPNLYR AVVALEYDGT LVEAEAYDVG FREVAIRNGL
360 370 380 390 400
LLLNGQPLLI RGTNRHEHHP QYGQAIDEAT MRQDILLMKQ HNFNAVRCSH
410 420 430 440 450
YPNHPLWYRL CDRYGLYVVD EANIETHGMQ PMSRLSDDPR WLPAYAERVT
460 470 480 490 500
RMVQRDRNHP CIIIWSLGNE SGYGPTHSAL YQWVKQQDPT RPVQYEGGGA
510 520 530 540 550
DTPATDILCP MYARVDQDQP FPAVPKWSIK KWIGLPGEHR PLILCEYAHA
560 570 580 590 600
MGNSFGGFDR YWQAFRQYPR LQGGFVWDWV DQALTREQDG KTHWAYGGDF
610 620 630 640 650
GDKPNDRQFC LNGLVFPDRT PHPALYEAQR AQQFFQFNHH ENAPLTLTIT
660 670 680 690 700
SEYLFRRSDN EELHWRIMQD DVQLASGRVP LDITPQGCQT LTLLEQLPAP
710 720 730 740 750
QHHADMWLTV EVIQPNATDW SPAGHRCAWD QWQLPMPLAR PTPRRDGSER
760 770 780 790 800
PTLTQNDDQF EVIHGQQRWA FNRHNGLLTQ WWRDGQAQLL SPLQDNLARA
810 820 830 840 850
PLDNDIGISE VDRIDPNAWV ERWKLAGLYR YDTDCRHIHA DTLSDGVLIT
860 870 880 890 900
TEHIGHYQQQ VLFISRKQWR IDAQGVLTVS VEVDVARHLP SLARVGLSMQ
910 920 930 940 950
LAAVTPQVSW LGLGPHENYP DRRLAALHGR WQQPLEAMHT PYIFPSENGL
960 970 980 990 1000
RCHTRELRYG DWLIEGDFHF GIGRYSRQQL MDCTHHHLLQ PEPGTWLNLD
1010 1020 1030
GFHMGIGGDD SWSPSVAPDF LLTAPRYRYQ LQLQLR
Length:1,036
Mass (Da):118,909
Last modified:September 1, 2009 - v1
Checksum:iA8794CDE12419D1C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001655 Genomic DNA. Translation: ACT07558.1.
RefSeqiWP_012770413.1. NC_012912.1.
YP_003005037.1. NC_012912.1.

Genome annotation databases

EnsemblBacteriaiACT07558; ACT07558; Dd1591_2733.
GeneIDi8119175.
KEGGidze:Dd1591_2733.
PATRICi21801475. VBIDicZea111179_2781.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001655 Genomic DNA. Translation: ACT07558.1 .
RefSeqi WP_012770413.1. NC_012912.1.
YP_003005037.1. NC_012912.1.

3D structure databases

ProteinModelPortali C6CN33.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 561229.Dd1591_2733.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACT07558 ; ACT07558 ; Dd1591_2733 .
GeneIDi 8119175.
KEGGi dze:Dd1591_2733.
PATRICi 21801475. VBIDicZea111179_2781.

Phylogenomic databases

eggNOGi COG3250.
HOGENOMi HOG000252443.
KOi K01190.
OMAi NPPFVPK.
OrthoDBi EOG6XWV0T.

Enzyme and pathway databases

BioCyci DZEA561229:GJ85-2791-MONOMER.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
2.60.40.320. 2 hits.
2.70.98.10. 1 hit.
3.20.20.80. 1 hit.
HAMAPi MF_01687. Beta_gal.
InterProi IPR004199. B-gal_small/dom_5.
IPR011013. Gal_mutarotase_SF_dom.
IPR008979. Galactose-bd-like.
IPR014718. Glyco_hydro-type_carb-bd_sub.
IPR006101. Glyco_hydro_2.
IPR013812. Glyco_hydro_2/20_Ig-like.
IPR023232. Glyco_hydro_2_AS.
IPR023933. Glyco_hydro_2_beta_Galsidase.
IPR023230. Glyco_hydro_2_CS.
IPR006102. Glyco_hydro_2_Ig-like.
IPR006104. Glyco_hydro_2_N.
IPR006103. Glyco_hydro_2_TIM.
IPR013781. Glyco_hydro_catalytic_dom.
IPR017853. Glycoside_hydrolase_SF.
[Graphical view ]
Pfami PF02929. Bgal_small_N. 1 hit.
PF00703. Glyco_hydro_2. 1 hit.
PF02836. Glyco_hydro_2_C. 1 hit.
PF02837. Glyco_hydro_2_N. 1 hit.
[Graphical view ]
PRINTSi PR00132. GLHYDRLASE2.
SMARTi SM01038. Bgal_small_N. 1 hit.
[Graphical view ]
SUPFAMi SSF49303. SSF49303. 2 hits.
SSF49785. SSF49785. 1 hit.
SSF51445. SSF51445. 1 hit.
SSF74650. SSF74650. 1 hit.
PROSITEi PS00719. GLYCOSYL_HYDROL_F2_1. 1 hit.
PS00608. GLYCOSYL_HYDROL_F2_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ech1591Imported.

Entry informationi

Entry nameiC6CN33_DICZE
AccessioniPrimary (citable) accession number: C6CN33
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 40 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3