C6CLZ7 (C6CLZ7_DICZE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Cytidine deaminase HAMAP MF_01558 PIRNR PIRNR006334
EC=3.5.4.5 HAMAP MF_01558 PIRNR PIRNR006334

Alternative name(s):
Cytidine aminohydrolase HAMAP MF_01558

Gene names

Name:	cdd HAMAP MF_01558
Ordered Locus Names:	Dd1591_2545

Organism

Dickeya zeae (strain Ech1591) [Complete proteome] [HAMAP] EMBL ACT07385.1

Taxonomic identifier

561229 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya

Protein attributes

Sequence length	295 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This enzyme scavenge exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis By similarity. HAMAP MF_01558 SAAS SAAS002125
Catalytic activity	Cytidine + H2O = uridine + NH3. HAMAP MF_01558 PIRNR PIRNR006334 SAAS SAAS002125
Cofactor	Binds 1 zinc ion By similarity. HAMAP MF_01558 PIRSR PIRSR006334-3 PIRNR PIRNR006334 SAAS SAAS002125
Subunit structure	Homodimer By similarity. HAMAP MF_01558 SAAS SAAS002125
Sequence similarities	Belongs to the cytidine and deoxycytidylate deaminase family. HAMAP MF_01558 PIRNR PIRNR006334

Ontologies

Keywords
Ligand	Metal-binding HAMAP MF_01558 PIRSR PIRSR006334-3 SAAS SAAS020797 PIRNR PIRNR006334 Zinc HAMAP MF_01558 PIRSR PIRSR006334-3 PIRNR PIRNR006334 SAAS SAAS020797
Molecular function	Hydrolase HAMAP MF_01558 PIRNR PIRNR006334 SAAS SAAS002125
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	cytidine deaminase activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Region	89 – 91	3	Substrate binding By similarity HAMAP MF_01558 PIRSR PIRSR006334-2
Sites
	Active site	104	1	Proton donor By similarity HAMAP MF_01558 PIRSR PIRSR006334-1
	Metal binding	102	1	Zinc; catalytic By similarity HAMAP MF_01558 PIRSR PIRSR006334-3
	Metal binding	129	1	Zinc; catalytic By similarity HAMAP MF_01558 PIRSR PIRSR006334-3
	Metal binding	132	1	Zinc; catalytic By similarity HAMAP MF_01558 PIRSR PIRSR006334-3

Sequences

	Sequence		Length	Mass (Da)
	C6CLZ7 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 21BA1009D9DD2C3D	FASTA	295	31,540
	10 20 30 40 50 60 MQARFHDAFT QLSAALQTAL TPILARDDFA AMLTADEVDR LCAQSQLDAD GLAFALLPLA 70 80 90 100 110 120 AACALTPVSG FHVGAIAQGV SGAFYWGANM EFDGLPLQQT VHAEQSAISH AWLRHESALR 130 140 150 160 170 180 AVTVNYTPCG HCRQFMNELN SAPELRICLP GRAPAPLGHY LPDAFGPRDL AIDTLLMDNI 190 200 210 220 230 240 DNGLTLTTDD TLCRLALAAA NHSHAPYSKA FSGIALETRQ GRRYTGRYAE NAAFNPSLPP 250 260 270 280 290 LQAALNLVNL AGDAFSDIQR AVLVESGHVA LSQWSLAQPL LASFGGTALQ RTLAY

References

[1]

"Complete sequence of Dickeya zeae Ech1591." Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Balakrishnan V., Glasner J., Perna N.T. Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Ech1591.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001655 Genomic DNA. Translation: ACT07385.1.
RefSeq	YP_003004864.1. NC_012912.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	C6CLZ7.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8120398.
GenomeReviews	Gene locus Dd1591_2545 in contig CP001655_GR.
KEGG	dze:Dd1591_2545.
PATRIC	21801105. VBIDicZea111179_2598.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NRSHAPY.
ProtClustDB	PRK09027.
Family and domain databases
HAMAP	MF_01558. Cyt_deam. [Tree]
InterPro	IPR016192. APOBEC/CMP_deaminase_Zn-bd. IPR002125. CMP_dCMP_Zn-bd. IPR013171. Cyd/dCyd_deaminase_Zn-bd. IPR006263. Cyt_deam_dimer. IPR016193. Cytidine_deaminase-like. IPR020797. Cytidine_deaminase_bacteria. [Graphical view]
KO	K01489.
PANTHER	PTHR11644:SF12. PTHR11644:SF12. 1 hit.
Pfam	PF00383. dCMP_cyt_deam_1. 1 hit. PF08211. dCMP_cyt_deam_2. 1 hit. [Graphical view]
PIRSF	PIRSF006334. Cdd_plus_pseudo. 1 hit.
SUPFAM	SSF53927. Cytidine_deaminase-like. 2 hits.
TIGRFAMs	TIGR01355. Cyt_deam_dimer. 1 hit.
PROSITE	PS00903. CYT_DCMP_DEAMINASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

C6CLZ7_DICZE

Accession

Primary (citable) accession number: C6CLZ7

Entry history

Integrated into UniProtKB/TrEMBL:	September 1, 2009
Last sequence update:	September 1, 2009
Last modified:	December 14, 2011
This is version 16 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)