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C6CFR2 (C6CFR2_DICZE) Unreviewed, UniProtKB/TrEMBL

Last modified May 1, 2013. Version 30. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotidine 5'-phosphate decarboxylase HAMAP-Rule MF_01200
EC=4.1.1.23 HAMAP-Rule MF_01200
Alternative name(s):
OMP decarboxylase HAMAP-Rule MF_01200
Gene names
Name:pyrF HAMAP-Rule MF_01200
Ordered Locus Names:Dd1591_1736
OrganismDickeya zeae (strain Ech1591) [Complete proteome] [HAMAP] EMBL ACT06588.1
Taxonomic identifier561229 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Enterobacteriales › Enterobacteriaceae › Dickeya ›

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP) By similarity. HAMAP-Rule MF_01200 SAAS SAAS014732

Catalytic activity

Orotidine 5'-phosphate = UMP + CO2. HAMAP-Rule MF_01200

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 2/2. HAMAP-Rule MF_01200

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01200 SAAS SAAS014732

Sequence similarities

Belongs to the OMP decarboxylase family. Type 1 subfamily. HAMAP-Rule MF_01200

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region71 – 8010Substrate binding By similarity HAMAP-Rule MF_01200

Sites

Active site731Proton donor By similarity HAMAP-Rule MF_01200
Binding site221Substrate By similarity HAMAP-Rule MF_01200
Binding site441Substrate By similarity HAMAP-Rule MF_01200
Binding site1311Substrate By similarity HAMAP-Rule MF_01200
Binding site1921Substrate By similarity HAMAP-Rule MF_01200
Binding site2011Substrate By similarity HAMAP-Rule MF_01200
Binding site2211Substrate; via amide nitrogen By similarity HAMAP-Rule MF_01200
Binding site2221Substrate By similarity HAMAP-Rule MF_01200

Sequences

Sequence LengthMass (Da)Tools
C6CFR2 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 30AFB7AF96BD0516

FASTA24425,991
        10         20         30         40         50         60 
MNGPTPSSNT LASGSPIIVA LDYAEQRAAY AFVDRIDPKD CRLKVGKEMF TLFGPQLVND 

        70         80         90        100        110        120 
LQQRGFEVFL DLKFHDIPNT TARAVAAAAE LGVWMVNVHA SGGARMMTAA RDALAPFGND 

       130        140        150        160        170        180 
APLLIAVTVL TSMDEADLQG LGISLSPAEQ AEKLARLTQQ CGLDGVVCSA HEALRLKQVC 

       190        200        210        220        230        240 
GTDFRLITPG IRPAGSDAGD QRRIMTPQQA QQAGVDYMVI GRPITQSADP AQTLKTILAS 


LGEK

« Hide

References

[1]"Complete sequence of Dickeya zeae Ech1591."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Chertkov O., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova G., Balakrishnan V., Glasner J., Perna N.T.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Ech1591.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001655 Genomic DNA. Translation: ACT06588.1.
RefSeqYP_003004067.1. NC_012912.1.

3D structure databases

ProteinModelPortalC6CFR2.
ModBaseSearch...

Protein-protein interaction databases

STRING561229.Dd1591_1736.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACT06588; ACT06588; Dd1591_1736.
GeneID8116819.
KEGGdze:Dd1591_1736.
PATRIC21799460. VBIDicZea111179_1779.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0284.
HOGENOMHOG000226071.
KOK01591.
OMANFKIFLD.
ProtClustDBCLSK2549425.

Enzyme and pathway databases

BioCycDZEA561229:GJ85-1789-MONOMER.
UniPathwayUPA00070; UER00120.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01200_B. OMPdecase_type1_B.
InterProIPR013785. Aldolase_TIM.
IPR014732. OMPdecase.
IPR018089. OMPdecase_AS.
IPR001754. OMPdeCOase_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00215. OMPdecase. 1 hit.
[Graphical view]
SMARTSM00934. OMPdecase. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR01740. pyrF. 1 hit.
PROSITEPS00156. OMPDECASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6CFR2_DICZE
AccessionPrimary (citable) accession number: C6CFR2
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: May 1, 2013
This is version 30 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
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