Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C6C9N5

- C6C9N5_DICDC

UniProt

C6C9N5 - C6C9N5_DICDC

Protein

Acetyltransferase component of pyruvate dehydrogenase complex

Gene

Dd703_0675

Organism
Dickeya dadantii (strain Ech703)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 36 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.UniRule annotation

    Catalytic activityi

    Acetyl-CoA + enzyme N(6)-(dihydrolipoyl)lysine = CoA + enzyme N(6)-(S-acetyldihydrolipoyl)lysine.

    Cofactori

    Binds 1 lipoyl cofactor covalently.UniRule annotation
    Binds 2 lipoyl cofactors covalently.UniRule annotation
    Binds 3 lipoyl cofactors covalently.UniRule annotation

    GO - Molecular functioni

    1. dihydrolipoyllysine-residue acetyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. glycolytic process Source: UniProtKB-KW

    Keywords - Molecular functioni

    AcyltransferaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    GlycolysisUniRule annotation

    Keywords - Ligandi

    PyruvateImported

    Enzyme and pathway databases

    BioCyciDDAD579405:GHJU-688-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Acetyltransferase component of pyruvate dehydrogenase complexUniRule annotation (EC:2.3.1.12UniRule annotation)
    Gene namesi
    Ordered Locus Names:Dd703_0675Imported
    OrganismiDickeya dadantii (strain Ech703)Imported
    Taxonomic identifieri579405 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
    ProteomesiUP000002734: Chromosome

    Subcellular locationi

    GO - Cellular componenti

    1. pyruvate dehydrogenase complex Source: InterPro

    Interactioni

    Subunit structurei

    Forms a 24-polypeptide structural core with octahedral symmetry.UniRule annotation

    Protein-protein interaction databases

    STRINGi579405.Dd703_0675.

    Structurei

    3D structure databases

    ProteinModelPortaliC6C9N5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 3 lipoyl-binding domains.UniRule annotation

    Keywords - Domaini

    LipoylUniRule annotationSAAS annotation

    Phylogenomic databases

    eggNOGiCOG0508.
    HOGENOMiHOG000281562.
    KOiK00627.
    OMAiTEIMVAV.
    OrthoDBiEOG610413.

    Family and domain databases

    Gene3Di3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProiIPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view]
    PfamiPF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 3 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view]
    SUPFAMiSSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 3 hits.
    TIGRFAMsiTIGR01348. PDHac_trf_long. 1 hit.
    PROSITEiPS50968. BIOTINYL_LIPOYL. 3 hits.
    PS00189. LIPOYL. 3 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6C9N5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAIEINVPDI GADEVEVTEV LVKVGDKVEA EQSLITVEGD KASMEVPSPQ    50
    AGVVKEIKIA VGDKVATGKL IMVFEAAGAP APAAAPAASA VKDVEVPDIG 100
    GDEVEVTEVL VKVGDTVAAE QSLITVEGDK ASMEVPAPFA GTVKEIKVST 150
    GSKVKTGTLI MVFEVAGAAP AVAAPAAAVS ALAAAPAVSG GAKDVNVPDI 200
    GGDEVEVTEV LVKVGDTVAA EQSLITVEGD KASMEVPAPF AGTVKEIKIS 250
    TGSKVKTGSL IMVFEVAGAA PAAAAAPAPV AAAPAASAPA AASAPAKADG 300
    KGEFAENDAY VHATPVIRRL AREFGVNLAK VKGTGRKGRI LREDVQAYVK 350
    DAVKRAESAP AAGATGGSLP GLLPWPKVDF SKFGEVEEVE LGRIQKISGA 400
    NLSRNWVMIP HVTHFDKTDI TDLEAFRKQQ NAEAEKRKLD VKFTPVVFIM 450
    KAVAAALEQM PRFNSSLSED AQRLTLKKYI NIGVAVDTPN GLVVPVFKDV 500
    NKKGIVELSR ELTVISKKAR DGKLTAGEMQ GGCFTISSIG GLGTTHFAPI 550
    VNAPEVAILG VSKSAMEPVW NGKEFVPRLM MPISLSFDHR VIDGADGARF 600
    ITIINNTLSD IRRLVM 616
    Length:616
    Mass (Da):63,922
    Last modified:September 1, 2009 - v1
    Checksum:i5788BB7835C5A854
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001654 Genomic DNA. Translation: ACS84486.1.
    RefSeqiYP_002986308.1. NC_012880.1.

    Genome annotation databases

    EnsemblBacteriaiACS84486; ACS84486; Dd703_0675.
    GeneIDi8089082.
    KEGGidda:Dd703_0675.
    PATRICi21788540. VBIDicDad95084_0720.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001654 Genomic DNA. Translation: ACS84486.1 .
    RefSeqi YP_002986308.1. NC_012880.1.

    3D structure databases

    ProteinModelPortali C6C9N5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 579405.Dd703_0675.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS84486 ; ACS84486 ; Dd703_0675 .
    GeneIDi 8089082.
    KEGGi dda:Dd703_0675.
    PATRICi 21788540. VBIDicDad95084_0720.

    Phylogenomic databases

    eggNOGi COG0508.
    HOGENOMi HOG000281562.
    KOi K00627.
    OMAi TEIMVAV.
    OrthoDBi EOG610413.

    Enzyme and pathway databases

    BioCyci DDAD579405:GHJU-688-MONOMER.

    Family and domain databases

    Gene3Di 3.30.559.10. 1 hit.
    4.10.320.10. 1 hit.
    InterProi IPR003016. 2-oxoA_DH_lipoyl-BS.
    IPR001078. 2-oxoacid_DH_actylTfrase.
    IPR006256. AcTrfase_Pyrv_DH_cplx.
    IPR000089. Biotin_lipoyl.
    IPR023213. CAT-like_dom.
    IPR004167. E3-bd.
    IPR011053. Single_hybrid_motif.
    [Graphical view ]
    Pfami PF00198. 2-oxoacid_dh. 1 hit.
    PF00364. Biotin_lipoyl. 3 hits.
    PF02817. E3_binding. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47005. SSF47005. 1 hit.
    SSF51230. SSF51230. 3 hits.
    TIGRFAMsi TIGR01348. PDHac_trf_long. 1 hit.
    PROSITEi PS50968. BIOTINYL_LIPOYL. 3 hits.
    PS00189. LIPOYL. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: Ech703Imported.

    Entry informationi

    Entry nameiC6C9N5_DICDC
    AccessioniPrimary (citable) accession number: C6C9N5
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 36 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3