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C6C6V4

- C6C6V4_DICDC

UniProt

C6C6V4 - C6C6V4_DICDC

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Protein

Isocitrate dehydrogenase [NADP]

Gene

Dd703_2060

Organism
Dickeya dadantii (strain Ech703)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH.UniRule annotation

Cofactori

Note: Binds 1 magnesium or manganese ion per subunit.UniRule annotation

GO - Molecular functioni

  1. isocitrate dehydrogenase (NADP+) activity Source: UniProtKB-EC
  2. magnesium ion binding Source: InterPro
  3. NAD binding Source: InterPro

GO - Biological processi

  1. glyoxylate cycle Source: UniProtKB-KW
  2. tricarboxylic acid cycle Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationImported

Keywords - Biological processi

Glyoxylate bypassUniRule annotation, Tricarboxylic acid cycleUniRule annotation

Keywords - Ligandi

ManganeseUniRule annotation, Metal-bindingUniRule annotation, NADPUniRule annotation

Enzyme and pathway databases

BioCyciDDAD579405:GHJU-2101-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NADP]UniRule annotation (EC:1.1.1.42UniRule annotation)
Gene namesi
Ordered Locus Names:Dd703_2060Imported
OrganismiDickeya dadantii (strain Ech703)Imported
Taxonomic identifieri579405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
ProteomesiUP000002734: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi579405.Dd703_2060.

Structurei

3D structure databases

ProteinModelPortaliC6C6V4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000021113.
KOiK00031.
OMAiCLRPIRY.
OrthoDBiEOG6SNDTP.

Family and domain databases

Gene3Di3.40.718.10. 1 hit.
InterProiIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERiPTHR11835. PTHR11835. 1 hit.
PfamiPF00180. Iso_dh. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00183. prok_nadp_idh. 1 hit.
PROSITEiPS00470. IDH_IMDH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6C6V4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MESKVVVPTE GQKITVDAQG KLIVPDNPII PFIEGDGIGI DVTPAMIKVV
60 70 80 90 100
DAAVKKAYQG QRTISWMEIY TGEKSTQIYG KDVWLPDETL DFIREYRVAI
110 120 130 140 150
KGPLTTPVGG GIRSLNVALR QQLDLYVCLR PVRYYEGTPS PVKQPELTDM
160 170 180 190 200
VIFRENAEDI YAGIEWKAGS AEADKVIKFL QDEMGVKKIR FPQQCGIGVK
210 220 230 240 250
PCSEEGTKRL VRAAIEYAIA NDRDSLTLVH KGNIMKFTEG AFKDWGYQLA
260 270 280 290 300
REEFGGELID GGPWVSIKNP NSGKEIVVKD VIADAFLQQI LLRPAEYDVI
310 320 330 340 350
ACMNLNGDYI SDALAAQVGG IGIAPGANIG DECALFEATH GTAPKYAGQD
360 370 380 390 400
KVNPGSVILS AEMMLRHLRW YEAADLIVKG MEGAIKNKTV TYDFERLMDG
410
AKLRKCSEFA QDIIDNM
Length:417
Mass (Da):45,960
Last modified:September 1, 2009 - v1
Checksum:iBA30E6F3C9068FA2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001654 Genomic DNA. Translation: ACS85848.1.
RefSeqiYP_002987670.1. NC_012880.1.

Genome annotation databases

EnsemblBacteriaiACS85848; ACS85848; Dd703_2060.
GeneIDi8090657.
KEGGidda:Dd703_2060.
PATRICi21791545. VBIDicDad95084_2195.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001654 Genomic DNA. Translation: ACS85848.1 .
RefSeqi YP_002987670.1. NC_012880.1.

3D structure databases

ProteinModelPortali C6C6V4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579405.Dd703_2060.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS85848 ; ACS85848 ; Dd703_2060 .
GeneIDi 8090657.
KEGGi dda:Dd703_2060.
PATRICi 21791545. VBIDicDad95084_2195.

Phylogenomic databases

HOGENOMi HOG000021113.
KOi K00031.
OMAi CLRPIRY.
OrthoDBi EOG6SNDTP.

Enzyme and pathway databases

BioCyci DDAD579405:GHJU-2101-MONOMER.

Family and domain databases

Gene3Di 3.40.718.10. 1 hit.
InterProi IPR019818. IsoCit/isopropylmalate_DH_CS.
IPR001804. Isocitrate/isopropylmalate_DH.
IPR004439. Isocitrate_DH_NADP_dimer_prok.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view ]
PANTHERi PTHR11835. PTHR11835. 1 hit.
Pfami PF00180. Iso_dh. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00183. prok_nadp_idh. 1 hit.
PROSITEi PS00470. IDH_IMDH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ech703Imported.

Entry informationi

Entry nameiC6C6V4_DICDC
AccessioniPrimary (citable) accession number: C6C6V4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3