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C6C5B9

- C6C5B9_DICDC

UniProt

C6C5B9 - C6C5B9_DICDC

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Protein
Glycerol kinase
Gene
glpK, Dd703_3803
Organism
Dickeya dadantii (strain Ech703)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate By similarity.UniRule annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotationSAAS annotations

Enzyme regulationi

Activity of this regulatory enzyme is affected by several metabolites. Allosterically and non-competitively inhibited by fructose 1,6-bisphosphate (FBP) and unphosphorylated phosphocarrier protein EIIA-Glc (III-Glc), an integral component of the bacterial phosphotransferase (PTS) system By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei15 – 151Substrate By similarityUniRule annotation
Binding sitei19 – 191ATP By similarityUniRule annotation
Binding sitei137 – 1371Substrate By similarityUniRule annotation
Binding sitei269 – 2691ATP By similarityUniRule annotation
Binding sitei312 – 3121ATP; via carbonyl oxygen By similarityUniRule annotation
Binding sitei316 – 3161ATP; via amide nitrogen By similarityUniRule annotation
Binding sitei331 – 3311ATP By similarityUniRule annotation
Metal bindingi480 – 4801Zinc; shared with EIIA-Glc By similarityUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi15 – 173ATP By similarityUniRule annotation
Nucleotide bindingi413 – 4175ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glycerol kinase activity Source: UniProtKB-HAMAP
  3. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. glycerol catabolic process Source: UniProtKB-UniPathway
  2. glycerol-3-phosphate metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationsImported, Transferase

Keywords - Biological processi

Glycerol metabolismUniRule annotationSAAS annotations

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotations, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Enzyme and pathway databases

BioCyciDDAD579405:GHJU-3897-MONOMER.
UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Dd703_3803Imported
OrganismiDickeya dadantii (strain Ech703)Imported
Taxonomic identifieri579405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacterialesEnterobacteriaceaeDickeya
ProteomesiUP000002734: Chromosome

Interactioni

Subunit structurei

Homotetramer and homodimer (in equilibrium). Heterodimer with EIIA-Glc. Binds 1 zinc ion per glycerol kinase EIIA-Glc dimer. The zinc ion is important for dimerization By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi579405.Dd703_3803.

Structurei

3D structure databases

ProteinModelPortaliC6C5B9.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni85 – 862Substrate binding By similarityUniRule annotation
Regioni235 – 2373Allosteric FBP inhibitor binding By similarityUniRule annotation
Regioni247 – 2482Substrate binding By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0554.
HOGENOMiHOG000222134.
KOiK00864.
OMAiHFFGVEV.
OrthoDBiEOG6RZB46.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin.
InterProiIPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6C5B9-1 [UniParc]FASTAAdd to Basket

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MSQEKKYIVA LDQGTTSSRA VVLDHDANIV SVSQREFPQI YPKPGWVEHD    50
PMEIWASQSS TLVEALAKAG ISSDEVAGIG ITNQRETVVV WEKETGKPIY 100
NAIVWQCRRT ADICEKLKKD GLEEYIRANT GLVVDPYFSG TKVKWILDHV 150
DGARDRANRG ELLLGTIDTW LIWKMTQGRV HVTDYTNASR TMLFNIHKLD 200
WDERMLEALD IPRSMLPQVR PSSEMYGQTN IGGKGGTRIP ICGIAGDQQA 250
ALYGQLCVQP GMAKNTYGTG CFLLMNTGTE AVASRHGLLT TIACGPRGEV 300
NYALEGAVFI GGASIQWLRD ELKLINDAAD SEYFATKVKD TNGVYVVPAF 350
TGLGAPYWDP YARGAIFGLT RGANANHIIR ATLESIAFQT RDVLDAMQAD 400
ADTRLQSLRV DGGAVANNFL MQFQSDILGT RVERPQVRES TALGAAFLAG 450
LATGFWNDLD EVKSKTAIER EFRPSIETVE RNFRYRGWQK AVERARNWED 500
HDA 503
Length:503
Mass (Da):55,776
Last modified:September 1, 2009 - v1
Checksum:i5825E56251D1F4B5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001654 Genomic DNA. Translation: ACS87556.1.
RefSeqiYP_002989378.1. NC_012880.1.

Genome annotation databases

EnsemblBacteriaiACS87556; ACS87556; Dd703_3803.
GeneIDi8087188.
KEGGidda:Dd703_3803.
PATRICi21795313. VBIDicDad95084_4030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001654 Genomic DNA. Translation: ACS87556.1 .
RefSeqi YP_002989378.1. NC_012880.1.

3D structure databases

ProteinModelPortali C6C5B9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 579405.Dd703_3803.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS87556 ; ACS87556 ; Dd703_3803 .
GeneIDi 8087188.
KEGGi dda:Dd703_3803.
PATRICi 21795313. VBIDicDad95084_4030.

Phylogenomic databases

eggNOGi COG0554.
HOGENOMi HOG000222134.
KOi K00864.
OMAi HFFGVEV.
OrthoDBi EOG6RZB46.

Enzyme and pathway databases

UniPathwayi UPA00618 ; UER00672 .
BioCyci DDAD579405:GHJU-3897-MONOMER.

Family and domain databases

HAMAPi MF_00186. Glycerol_kin.
InterProi IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view ]
Pfami PF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR01311. glycerol_kin. 1 hit.
PROSITEi PS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Ech703Imported.

Entry informationi

Entry nameiC6C5B9_DICDC
AccessioniPrimary (citable) accession number: C6C5B9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Allosteric enzymeUniRule annotation, Complete proteome

External Data

Dasty 3

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