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Protein

Glycerol kinase

Gene

glpK

Organism
Dickeya dadantii (strain Ech703)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.UniRule annotationSAAS annotation

Catalytic activityi

ATP + glycerol = ADP + sn-glycerol 3-phosphate.UniRule annotationSAAS annotation

Enzyme regulationi

Inhibited by fructose 1,6-bisphosphate (FBP).UniRule annotation

Pathwayi: glycerol degradation via glycerol kinase pathway

This protein is involved in step 1 of the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol.UniRule annotationSAAS annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Glycerol kinase (glpK)
This subpathway is part of the pathway glycerol degradation via glycerol kinase pathway, which is itself part of Polyol metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes sn-glycerol 3-phosphate from glycerol, the pathway glycerol degradation via glycerol kinase pathway and in Polyol metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei15SubstrateUniRule annotation1
Binding sitei19ATPUniRule annotation1
Binding sitei137SubstrateUniRule annotation1
Binding sitei269ATPUniRule annotation1
Binding sitei312ATP; via carbonyl oxygenUniRule annotation1
Binding sitei316ATP; via amide nitrogenUniRule annotation1
Binding sitei331ATPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi15 – 17ATPUniRule annotation3
Nucleotide bindingi413 – 417ATPUniRule annotation5

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationSAAS annotationImported, Transferase

Keywords - Biological processi

Glycerol metabolismUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol kinaseUniRule annotation (EC:2.7.1.30UniRule annotation)
Alternative name(s):
ATP:glycerol 3-phosphotransferaseUniRule annotation
GlycerokinaseUniRule annotation
Gene namesi
Name:glpKUniRule annotation
Ordered Locus Names:Dd703_3803Imported
OrganismiDickeya dadantii (strain Ech703)Imported
Taxonomic identifieri579405 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaEnterobacteralesPectobacteriaceaeDickeya
Proteomesi
  • UP000002734 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi579405.Dd703_3803.

Structurei

3D structure databases

ProteinModelPortaliC6C5B9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini7 – 254FGGY_NInterPro annotationAdd BLAST248
Domaini263 – 452FGGY_CInterPro annotationAdd BLAST190

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni85 – 86Substrate bindingUniRule annotation2
Regioni247 – 248Substrate bindingUniRule annotation2

Sequence similaritiesi

Belongs to the FGGY kinase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4107QVN. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
KOiK00864.
OMAiPMEIFAT.
OrthoDBiPOG091H02FA.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6C5B9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQEKKYIVA LDQGTTSSRA VVLDHDANIV SVSQREFPQI YPKPGWVEHD
60 70 80 90 100
PMEIWASQSS TLVEALAKAG ISSDEVAGIG ITNQRETVVV WEKETGKPIY
110 120 130 140 150
NAIVWQCRRT ADICEKLKKD GLEEYIRANT GLVVDPYFSG TKVKWILDHV
160 170 180 190 200
DGARDRANRG ELLLGTIDTW LIWKMTQGRV HVTDYTNASR TMLFNIHKLD
210 220 230 240 250
WDERMLEALD IPRSMLPQVR PSSEMYGQTN IGGKGGTRIP ICGIAGDQQA
260 270 280 290 300
ALYGQLCVQP GMAKNTYGTG CFLLMNTGTE AVASRHGLLT TIACGPRGEV
310 320 330 340 350
NYALEGAVFI GGASIQWLRD ELKLINDAAD SEYFATKVKD TNGVYVVPAF
360 370 380 390 400
TGLGAPYWDP YARGAIFGLT RGANANHIIR ATLESIAFQT RDVLDAMQAD
410 420 430 440 450
ADTRLQSLRV DGGAVANNFL MQFQSDILGT RVERPQVRES TALGAAFLAG
460 470 480 490 500
LATGFWNDLD EVKSKTAIER EFRPSIETVE RNFRYRGWQK AVERARNWED

HDA
Length:503
Mass (Da):55,776
Last modified:September 1, 2009 - v1
Checksum:i5825E56251D1F4B5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001654 Genomic DNA. Translation: ACS87556.1.

Genome annotation databases

EnsemblBacteriaiACS87556; ACS87556; Dd703_3803.
KEGGidda:Dd703_3803.
PATRICi21795313. VBIDicDad95084_4030.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001654 Genomic DNA. Translation: ACS87556.1.

3D structure databases

ProteinModelPortaliC6C5B9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi579405.Dd703_3803.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS87556; ACS87556; Dd703_3803.
KEGGidda:Dd703_3803.
PATRICi21795313. VBIDicDad95084_4030.

Phylogenomic databases

eggNOGiENOG4107QVN. Bacteria.
COG0554. LUCA.
HOGENOMiHOG000222134.
KOiK00864.
OMAiPMEIFAT.
OrthoDBiPOG091H02FA.

Enzyme and pathway databases

UniPathwayiUPA00618; UER00672.

Family and domain databases

HAMAPiMF_00186. Glycerol_kin. 1 hit.
InterProiIPR000577. Carb_kinase_FGGY.
IPR018485. Carb_kinase_FGGY_C.
IPR018483. Carb_kinase_FGGY_CS.
IPR018484. Carb_kinase_FGGY_N.
IPR005999. Glycerol_kin.
[Graphical view]
PfamiPF02782. FGGY_C. 1 hit.
PF00370. FGGY_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000538. GlpK. 1 hit.
TIGRFAMsiTIGR01311. glycerol_kin. 1 hit.
PROSITEiPS00933. FGGY_KINASES_1. 1 hit.
PS00445. FGGY_KINASES_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC6C5B9_DICDC
AccessioniPrimary (citable) accession number: C6C5B9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.