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C6C1U6

- PANC_DESAD

UniProt

C6C1U6 - PANC_DESAD

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Protein

Pantothenate synthetase

Gene

panC

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation

Catalytic activityi

ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei37 – 371Proton donorUniRule annotation
Binding sitei61 – 611Beta-alanineUniRule annotation
Binding sitei61 – 611PantoateUniRule annotation
Binding sitei153 – 1531PantoateUniRule annotation
Binding sitei176 – 1761ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi30 – 378ATPUniRule annotation
Nucleotide bindingi147 – 1504ATPUniRule annotation
Nucleotide bindingi184 – 1874ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciDSAL526222:GHES-1302-MONOMER.
UniPathwayiUPA00028; UER00005.

Names & Taxonomyi

Protein namesi
Recommended name:
Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
Short name:
PSUniRule annotation
Alternative name(s):
Pantoate--beta-alanine ligaseUniRule annotation
Pantoate-activating enzymeUniRule annotation
Gene namesi
Name:panCUniRule annotation
Ordered Locus Names:Desal_1279
OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Taxonomic identifieri526222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002601: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 282282Pantothenate synthetasePRO_1000203486Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi526222.Desal_1279.

Family & Domainsi

Sequence similaritiesi

Belongs to the pantothenate synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0414.
HOGENOMiHOG000175516.
KOiK01918.
OMAiASSKENH.
OrthoDBiEOG6Z6FZ4.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00158. PanC.
InterProiIPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR21299:SF1. PTHR21299:SF1. 1 hit.
PfamiPF02569. Pantoate_ligase. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.

Sequencei

Sequence statusi: Complete.

C6C1U6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
METISNPQEL QNLCLMLRAE GKKIGLVPTM GYFHEGHLSL MDAARKQCDV
60 70 80 90 100
LIVSLFVNPT QFGENEDLDA YPHNLERDSE LAEKRGVDIL FTPIRDDMYF
110 120 130 140 150
EDHSTWVEVP DLATNLCGKS RPIHFRGVAT VVTKLFMTAQ PHVAVFGQKD
160 170 180 190 200
WQQLAIIKRM VRDLNIPVDV QGHEIVREES GLALSSRNVY LTEDEKSVAP
210 220 230 240 250
NIQKGLQKMR DWVTAGESDA AKLKSDLVEF YAETIPTGRV DYIEIVHPEN
260 270 280
INILKNVGDS ALCAVAIQLG NARLIDNLLI KV
Length:282
Mass (Da):31,666
Last modified:September 1, 2009 - v1
Checksum:i2F4D78385D4CBE3E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001649 Genomic DNA. Translation: ACS79342.1.
RefSeqiYP_002990881.1. NC_012881.1.

Genome annotation databases

EnsemblBacteriaiACS79342; ACS79342; Desal_1279.
GeneIDi8091979.
KEGGidsa:Desal_1279.
PATRICi21758055. VBIDesSal121003_1291.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001649 Genomic DNA. Translation: ACS79342.1 .
RefSeqi YP_002990881.1. NC_012881.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 526222.Desal_1279.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS79342 ; ACS79342 ; Desal_1279 .
GeneIDi 8091979.
KEGGi dsa:Desal_1279.
PATRICi 21758055. VBIDesSal121003_1291.

Phylogenomic databases

eggNOGi COG0414.
HOGENOMi HOG000175516.
KOi K01918.
OMAi ASSKENH.
OrthoDBi EOG6Z6FZ4.

Enzyme and pathway databases

UniPathwayi UPA00028 ; UER00005 .
BioCyci DSAL526222:GHES-1302-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
HAMAPi MF_00158. PanC.
InterProi IPR004821. Cyt_trans-like.
IPR003721. Pantoate_ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR21299:SF1. PTHR21299:SF1. 1 hit.
Pfami PF02569. Pantoate_ligase. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00125. cyt_tran_rel. 1 hit.
TIGR00018. panC. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763.

Entry informationi

Entry nameiPANC_DESAD
AccessioniPrimary (citable) accession number: C6C1U6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

The reaction proceeds by a bi uni uni bi ping pong mechanism.UniRule annotation

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3