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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei60SubstrateUniRule annotation1
Binding sitei136SubstrateUniRule annotation1
Binding sitei197SubstrateUniRule annotation1
Binding sitei227SubstrateUniRule annotation1
Binding sitei231SubstrateUniRule annotation1
Binding sitei232NADUniRule annotation1
Binding sitei284NADUniRule annotation1
Binding sitei319NADUniRule annotation1
Binding sitei388NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi198 – 200NADUniRule annotation3
Nucleotide bindingi261 – 266NADUniRule annotation6
Nucleotide bindingi340 – 342NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Ordered Locus Names:Desal_3077
OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Taxonomic identifieri526222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002601 Componenti: Chromosome

Subcellular locationi

C6C1F4:
  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002120531 – 472AdenosylhomocysteinaseAdd BLAST472

Proteomic databases

PRIDEiC6C1F4.

Interactioni

Protein-protein interaction databases

STRINGi526222.Desal_3077.

Structurei

3D structure databases

ProteinModelPortaliC6C1F4.
SMRiC6C1F4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227987.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

C6C1F4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLKVDSKLDY KVADISLADW GNKEMQLSER EMPGLMSIRE KYGKEKPLKG
60 70 80 90 100
LKVMGSLHMT IQTAMLIETL HALGADIRWA SCNIFSTQDH AAAAIAANGT
110 120 130 140 150
AKVFAWKGET LEEYWWCTEQ ALTWPDGSGP DLIVDDGGDA TLLIHHGVKA
160 170 180 190 200
EKDASILDEK TDNKEFQCVL DRLKLSVAET PGKWTAIAEK VRGVSEETTT
210 220 230 240 250
GVHRLYQMQE AGELLFPAIN VNDSVTKSKF DNLYGCRESL ADGIKRATDV
260 270 280 290 300
MIAGKVVVVV GYGDVGKGCA QSMRGFGARV LVTEIDPICA LQAAMEGFEV
310 320 330 340 350
CTMANAVERG DVFVTCTGNY HVITGEHISK MKDEAIICNI GHFDNEIEMG
360 370 380 390 400
YLENSKTAKK IEIKPQVDKW VMESGKSVIV LAEGRLVNLG CATGHPSFVM
410 420 430 440 450
SNSFTNQALA QIDLAKNEYE PKVMILSKKL DEEVARLHLE RLGVELDVLS
460 470
KEQADYISVD VEGPYKPDHY RY
Length:472
Mass (Da):52,049
Last modified:September 1, 2009 - v1
Checksum:iA7B2BA54C6739A0E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001649 Genomic DNA. Translation: ACS81129.1.
RefSeqiWP_015852945.1. NC_012881.1.

Genome annotation databases

EnsemblBacteriaiACS81129; ACS81129; Desal_3077.
KEGGidsa:Desal_3077.

Similar proteinsi

Entry informationi

Entry nameiSAHH_DESAD
AccessioniPrimary (citable) accession number: C6C1F4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 25, 2017
This is version 54 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families