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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase

Enzyme and pathway databases

BioCyciDSAL526222:G1GF5-3040-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Desal_2995
OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Taxonomic identifieri526222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002601 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126591 – 443Probable glycine dehydrogenase (decarboxylating) subunit 1Add BLAST443

Proteomic databases

PRIDEiC6C0V0

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi526222.Desal_2995

Structurei

3D structure databases

ProteinModelPortaliC6C0V0
SMRiC6C0V0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4107QK8 Bacteria
COG0403 LUCA
HOGENOMiHOG000132025
KOiK00282
OMAiMYDGASA
OrthoDBiPOG091H0JKN

Family and domain databases

CDDicd00613 GDC-P, 1 hit
Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
HAMAPiMF_00712 GcvPA, 1 hit
InterProiView protein in InterPro
IPR023010 GcvPA
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR42806 PTHR42806, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 1 hit
PIRSFiPIRSF006815 GcvPA, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

C6C0V0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPYVPHSPEE IREMLDVIGV NSVEDLFAEI PAELRPKSFN LPKGKSEMAV
60 70 80 90 100
LQQLDKMAAK NTTDLTSFLG AGFYDHFIPT AVDALSSRSE FYTAYTPYQP
110 120 130 140 150
ESSQGTLQAI FEYQTAMARL MDMDYANASV YDGGSALYEA TLMAVRKTRR
160 170 180 190 200
RKIIVSEALN PIYRVMLDSY TTNLNLELVT VPHNHGRTNV KSITAAVDKD
210 220 230 240 250
TAAVIVQNPN FFGSVNDFTE MFAAVHEHKA LAIMSTYPVM QSVLKTPGQM
260 270 280 290 300
GADIAVADGQ SIGQPLSFGG PYLGIMTCSK ALVRQMPGRI AGRTEDEDGK
310 320 330 340 350
TGYVLTIQAR EQHIRRQKAT SNICSNQALC ALRTLIHLCL LGEEGLNRTA
360 370 380 390 400
VLSVERAHYA AERLTAIDGV EMFTKGPFGN EFAVTLPVNA FEVIDKLTER
410 420 430 440
GIIPGFPVGR YYEGLENVLL VACTEKTTEE QIGIFAEILR GTI
Length:443
Mass (Da):48,716
Last modified:September 1, 2009 - v1
Checksum:i998A3B75AB2E2299
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001649 Genomic DNA Translation: ACS81047.1
RefSeqiWP_015852863.1, NC_012881.1

Genome annotation databases

EnsemblBacteriaiACS81047; ACS81047; Desal_2995
KEGGidsa:Desal_2995

Similar proteinsi

Entry informationi

Entry nameiGCSPA_DESAD
AccessioniPrimary (citable) accession number: C6C0V0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 53 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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