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C6C0V0

- GCSPA_DESAD

UniProt

C6C0V0 - GCSPA_DESAD

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciDSAL526222:GHES-3067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-protein subunit 1UniRule annotation
Glycine decarboxylase subunit 1UniRule annotation
Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
Gene namesi
Name:gcvPAUniRule annotation
Ordered Locus Names:Desal_2995
OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Taxonomic identifieri526222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000212659Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

Protein-protein interaction databases

STRINGi526222.Desal_2995.

Structurei

3D structure databases

ProteinModelPortaliC6C0V0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C6C0V0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPYVPHSPEE IREMLDVIGV NSVEDLFAEI PAELRPKSFN LPKGKSEMAV
60 70 80 90 100
LQQLDKMAAK NTTDLTSFLG AGFYDHFIPT AVDALSSRSE FYTAYTPYQP
110 120 130 140 150
ESSQGTLQAI FEYQTAMARL MDMDYANASV YDGGSALYEA TLMAVRKTRR
160 170 180 190 200
RKIIVSEALN PIYRVMLDSY TTNLNLELVT VPHNHGRTNV KSITAAVDKD
210 220 230 240 250
TAAVIVQNPN FFGSVNDFTE MFAAVHEHKA LAIMSTYPVM QSVLKTPGQM
260 270 280 290 300
GADIAVADGQ SIGQPLSFGG PYLGIMTCSK ALVRQMPGRI AGRTEDEDGK
310 320 330 340 350
TGYVLTIQAR EQHIRRQKAT SNICSNQALC ALRTLIHLCL LGEEGLNRTA
360 370 380 390 400
VLSVERAHYA AERLTAIDGV EMFTKGPFGN EFAVTLPVNA FEVIDKLTER
410 420 430 440
GIIPGFPVGR YYEGLENVLL VACTEKTTEE QIGIFAEILR GTI
Length:443
Mass (Da):48,716
Last modified:September 1, 2009 - v1
Checksum:i998A3B75AB2E2299
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001649 Genomic DNA. Translation: ACS81047.1.
RefSeqiYP_002992586.1. NC_012881.1.

Genome annotation databases

EnsemblBacteriaiACS81047; ACS81047; Desal_2995.
GeneIDi8093677.
KEGGidsa:Desal_2995.
PATRICi21761549. VBIDesSal121003_2991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001649 Genomic DNA. Translation: ACS81047.1 .
RefSeqi YP_002992586.1. NC_012881.1.

3D structure databases

ProteinModelPortali C6C0V0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 526222.Desal_2995.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS81047 ; ACS81047 ; Desal_2995 .
GeneIDi 8093677.
KEGGi dsa:Desal_2995.
PATRICi 21761549. VBIDesSal121003_2991.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci DSAL526222:GHES-3067-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763.

Entry informationi

Entry nameiGCSPA_DESAD
AccessioniPrimary (citable) accession number: C6C0V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3