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C6C0V0

- GCSPA_DESAD

UniProt

C6C0V0 - GCSPA_DESAD

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Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene
gcvPA, Desal_2995
Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

GO - Molecular functioni

  1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
  2. pyridoxal phosphate binding Source: InterPro

GO - Biological processi

  1. glycine catabolic process Source: InterPro
  2. nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Enzyme and pathway databases

BioCyciDSAL526222:GHES-3067-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable glycine dehydrogenase (decarboxylating) subunit 1 (EC:1.4.4.2)
Alternative name(s):
Glycine cleavage system P-protein subunit 1
Glycine decarboxylase subunit 1
Glycine dehydrogenase (aminomethyl-transferring) subunit 1
Gene namesi
Name:gcvPA
Ordered Locus Names:Desal_2995
OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Taxonomic identifieri526222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
ProteomesiUP000002601: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotationPRO_1000212659Add
BLAST

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits By similarity.

Protein-protein interaction databases

STRINGi526222.Desal_2995.

Structurei

3D structure databases

ProteinModelPortaliC6C0V0.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0403.
HOGENOMiHOG000132025.
KOiK00282.
OMAiFFHEAVL.
OrthoDBiEOG6XWV3B.

Family and domain databases

Gene3Di3.40.640.10. 1 hit.
HAMAPiMF_00712. GcvPA.
InterProiIPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 1 hit.
[Graphical view]
PIRSFiPIRSF006815. GcvPA. 1 hit.
SUPFAMiSSF53383. SSF53383. 1 hit.

Sequencei

Sequence statusi: Complete.

C6C0V0-1 [UniParc]FASTAAdd to Basket

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MPYVPHSPEE IREMLDVIGV NSVEDLFAEI PAELRPKSFN LPKGKSEMAV    50
LQQLDKMAAK NTTDLTSFLG AGFYDHFIPT AVDALSSRSE FYTAYTPYQP 100
ESSQGTLQAI FEYQTAMARL MDMDYANASV YDGGSALYEA TLMAVRKTRR 150
RKIIVSEALN PIYRVMLDSY TTNLNLELVT VPHNHGRTNV KSITAAVDKD 200
TAAVIVQNPN FFGSVNDFTE MFAAVHEHKA LAIMSTYPVM QSVLKTPGQM 250
GADIAVADGQ SIGQPLSFGG PYLGIMTCSK ALVRQMPGRI AGRTEDEDGK 300
TGYVLTIQAR EQHIRRQKAT SNICSNQALC ALRTLIHLCL LGEEGLNRTA 350
VLSVERAHYA AERLTAIDGV EMFTKGPFGN EFAVTLPVNA FEVIDKLTER 400
GIIPGFPVGR YYEGLENVLL VACTEKTTEE QIGIFAEILR GTI 443
Length:443
Mass (Da):48,716
Last modified:September 1, 2009 - v1
Checksum:i998A3B75AB2E2299
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001649 Genomic DNA. Translation: ACS81047.1.
RefSeqiWP_015852863.1. NC_012881.1.
YP_002992586.1. NC_012881.1.

Genome annotation databases

EnsemblBacteriaiACS81047; ACS81047; Desal_2995.
GeneIDi8093677.
KEGGidsa:Desal_2995.
PATRICi21761549. VBIDesSal121003_2991.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001649 Genomic DNA. Translation: ACS81047.1 .
RefSeqi WP_015852863.1. NC_012881.1.
YP_002992586.1. NC_012881.1.

3D structure databases

ProteinModelPortali C6C0V0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 526222.Desal_2995.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS81047 ; ACS81047 ; Desal_2995 .
GeneIDi 8093677.
KEGGi dsa:Desal_2995.
PATRICi 21761549. VBIDesSal121003_2991.

Phylogenomic databases

eggNOGi COG0403.
HOGENOMi HOG000132025.
KOi K00282.
OMAi FFHEAVL.
OrthoDBi EOG6XWV3B.

Enzyme and pathway databases

BioCyci DSAL526222:GHES-3067-MONOMER.

Family and domain databases

Gene3Di 3.40.640.10. 1 hit.
HAMAPi MF_00712. GcvPA.
InterProi IPR023010. GcvPA.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view ]
PANTHERi PTHR11773. PTHR11773. 1 hit.
Pfami PF02347. GDC-P. 1 hit.
[Graphical view ]
PIRSFi PIRSF006815. GcvPA. 1 hit.
SUPFAMi SSF53383. SSF53383. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763.

Entry informationi

Entry nameiGCSPA_DESAD
AccessioniPrimary (citable) accession number: C6C0V0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: September 3, 2014
This is version 33 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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