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C6C0V0

- GCSPA_DESAD

UniProt

C6C0V0 - GCSPA_DESAD

Protein

Probable glycine dehydrogenase (decarboxylating) subunit 1

Gene

gcvPA

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 34 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

    Catalytic activityi

    Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

    GO - Molecular functioni

    1. glycine dehydrogenase (decarboxylating) activity Source: UniProtKB-EC
    2. pyridoxal phosphate binding Source: InterPro

    GO - Biological processi

    1. glycine catabolic process Source: InterPro
    2. nucleoside metabolic process Source: InterPro

    Keywords - Molecular functioni

    Oxidoreductase

    Enzyme and pathway databases

    BioCyciDSAL526222:GHES-3067-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable glycine dehydrogenase (decarboxylating) subunit 1UniRule annotation (EC:1.4.4.2UniRule annotation)
    Alternative name(s):
    Glycine cleavage system P-protein subunit 1UniRule annotation
    Glycine decarboxylase subunit 1UniRule annotation
    Glycine dehydrogenase (aminomethyl-transferring) subunit 1UniRule annotation
    Gene namesi
    Name:gcvPAUniRule annotation
    Ordered Locus Names:Desal_2995
    OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
    Taxonomic identifieri526222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 443443Probable glycine dehydrogenase (decarboxylating) subunit 1PRO_1000212659Add
    BLAST

    Interactioni

    Subunit structurei

    The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi526222.Desal_2995.

    Structurei

    3D structure databases

    ProteinModelPortaliC6C0V0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GcvP family. N-terminal subunit subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0403.
    HOGENOMiHOG000132025.
    KOiK00282.
    OMAiFFHEAVL.
    OrthoDBiEOG6XWV3B.

    Family and domain databases

    Gene3Di3.40.640.10. 1 hit.
    HAMAPiMF_00712. GcvPA.
    InterProiIPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view]
    PANTHERiPTHR11773. PTHR11773. 1 hit.
    PfamiPF02347. GDC-P. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006815. GcvPA. 1 hit.
    SUPFAMiSSF53383. SSF53383. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6C0V0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPYVPHSPEE IREMLDVIGV NSVEDLFAEI PAELRPKSFN LPKGKSEMAV    50
    LQQLDKMAAK NTTDLTSFLG AGFYDHFIPT AVDALSSRSE FYTAYTPYQP 100
    ESSQGTLQAI FEYQTAMARL MDMDYANASV YDGGSALYEA TLMAVRKTRR 150
    RKIIVSEALN PIYRVMLDSY TTNLNLELVT VPHNHGRTNV KSITAAVDKD 200
    TAAVIVQNPN FFGSVNDFTE MFAAVHEHKA LAIMSTYPVM QSVLKTPGQM 250
    GADIAVADGQ SIGQPLSFGG PYLGIMTCSK ALVRQMPGRI AGRTEDEDGK 300
    TGYVLTIQAR EQHIRRQKAT SNICSNQALC ALRTLIHLCL LGEEGLNRTA 350
    VLSVERAHYA AERLTAIDGV EMFTKGPFGN EFAVTLPVNA FEVIDKLTER 400
    GIIPGFPVGR YYEGLENVLL VACTEKTTEE QIGIFAEILR GTI 443
    Length:443
    Mass (Da):48,716
    Last modified:September 1, 2009 - v1
    Checksum:i998A3B75AB2E2299
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001649 Genomic DNA. Translation: ACS81047.1.
    RefSeqiWP_015852863.1. NC_012881.1.
    YP_002992586.1. NC_012881.1.

    Genome annotation databases

    EnsemblBacteriaiACS81047; ACS81047; Desal_2995.
    GeneIDi8093677.
    KEGGidsa:Desal_2995.
    PATRICi21761549. VBIDesSal121003_2991.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001649 Genomic DNA. Translation: ACS81047.1 .
    RefSeqi WP_015852863.1. NC_012881.1.
    YP_002992586.1. NC_012881.1.

    3D structure databases

    ProteinModelPortali C6C0V0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 526222.Desal_2995.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS81047 ; ACS81047 ; Desal_2995 .
    GeneIDi 8093677.
    KEGGi dsa:Desal_2995.
    PATRICi 21761549. VBIDesSal121003_2991.

    Phylogenomic databases

    eggNOGi COG0403.
    HOGENOMi HOG000132025.
    KOi K00282.
    OMAi FFHEAVL.
    OrthoDBi EOG6XWV3B.

    Enzyme and pathway databases

    BioCyci DSAL526222:GHES-3067-MONOMER.

    Family and domain databases

    Gene3Di 3.40.640.10. 1 hit.
    HAMAPi MF_00712. GcvPA.
    InterProi IPR023010. GcvPA.
    IPR020580. GDC-P_N.
    IPR020581. GDC_P.
    IPR015424. PyrdxlP-dep_Trfase.
    IPR015421. PyrdxlP-dep_Trfase_major_sub1.
    [Graphical view ]
    PANTHERi PTHR11773. PTHR11773. 1 hit.
    Pfami PF02347. GDC-P. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006815. GcvPA. 1 hit.
    SUPFAMi SSF53383. SSF53383. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763.

    Entry informationi

    Entry nameiGCSPA_DESAD
    AccessioniPrimary (citable) accession number: C6C0V0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 34 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3