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C6C0U6

- GCH4_DESAD

UniProt

C6C0U6 - GCH4_DESAD

Protein

GTP cyclohydrolase FolE2

Gene

folE2

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    • Comment

    Functioni

    Converts GTP to 7,8-dihydroneopterin triphosphate.UniRule annotation

    Catalytic activityi

    GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei145 – 1451May be catalytically importantUniRule annotation

    GO - Molecular functioni

    1. GTP cyclohydrolase I activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Hydrolase

    Enzyme and pathway databases

    BioCyciDSAL526222:GHES-3063-MONOMER.
    UniPathwayiUPA00848; UER00151.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    GTP cyclohydrolase FolE2UniRule annotation (EC:3.5.4.16UniRule annotation)
    Gene namesi
    Name:folE2UniRule annotation
    Ordered Locus Names:Desal_2991
    OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
    Taxonomic identifieri526222 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
    ProteomesiUP000002601: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 256256GTP cyclohydrolase FolE2PRO_1000215387Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi526222.Desal_2991.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GTP cyclohydrolase IV family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1469.
    HOGENOMiHOG000280679.
    KOiK09007.
    OMAiDVQSSRD.
    OrthoDBiEOG6X6RBH.

    Family and domain databases

    HAMAPiMF_01527_B. GTP_cyclohydrol_B.
    InterProiIPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view]
    PfamiPF02649. GCHY-1. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6C0U6-1 [UniParc]FASTAAdd to Basket

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    MEDVQNSPAK VAMSIDRVGV RDLTLPLVVR DRESGSQSTM AKVALSVDLP    50
    AHFKGTHMSR FVEALEDWSE ELDYQSFYNL LSDILRRLEA ERAHAELSFP 100
    YCLQKKSPVS GRKGIMSYEC TVEGEMVGDN LEFTLGVKVP VMTVCPCSKA 150
    ISDEGAHSQR AVVHIRTKSK GFVWIEDLVE IAEASGSCEV FSLLKREDEK 200
    HVTEKSFSNP TFVEDVVRNA AMGLEKHSKI LWYQVDVESF ESIHNHCAFA 250
    SIAKPK 256
    Length:256
    Mass (Da):28,658
    Last modified:September 1, 2009 - v1
    Checksum:i857FA7FE6E0DEDDC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001649 Genomic DNA. Translation: ACS81043.1.
    RefSeqiYP_002992582.1. NC_012881.1.

    Genome annotation databases

    EnsemblBacteriaiACS81043; ACS81043; Desal_2991.
    GeneIDi8093673.
    KEGGidsa:Desal_2991.
    PATRICi21761541. VBIDesSal121003_2987.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001649 Genomic DNA. Translation: ACS81043.1 .
    RefSeqi YP_002992582.1. NC_012881.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 526222.Desal_2991.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS81043 ; ACS81043 ; Desal_2991 .
    GeneIDi 8093673.
    KEGGi dsa:Desal_2991.
    PATRICi 21761541. VBIDesSal121003_2987.

    Phylogenomic databases

    eggNOGi COG1469.
    HOGENOMi HOG000280679.
    KOi K09007.
    OMAi DVQSSRD.
    OrthoDBi EOG6X6RBH.

    Enzyme and pathway databases

    UniPathwayi UPA00848 ; UER00151 .
    BioCyci DSAL526222:GHES-3063-MONOMER.

    Family and domain databases

    HAMAPi MF_01527_B. GTP_cyclohydrol_B.
    InterProi IPR022838. GTP_cyclohydrolase_FolE2.
    IPR003801. GTP_cyclohydrolase_FolE2/MptA.
    [Graphical view ]
    Pfami PF02649. GCHY-1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763.

    Entry informationi

    Entry nameiGCH4_DESAD
    AccessioniPrimary (citable) accession number: C6C0U6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3