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C6C0U6 (GCH4_DESAD) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
GTP cyclohydrolase FolE2

EC=3.5.4.16
Gene names
Name:folE2
Ordered Locus Names:Desal_2991
OrganismDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763) [Complete proteome] [HAMAP]
Taxonomic identifier526222 [NCBI]
Taxonomic lineageBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio

Protein attributes

Sequence length256 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Converts GTP to 7,8-dihydroneopterin triphosphate By similarity. HAMAP-Rule MF_01527

Catalytic activity

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_01527

Pathway

Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_01527

Sequence similarities

Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_process7,8-dihydroneopterin 3'-triphosphate biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-UniPathway

   Molecular_functionGTP cyclohydrolase I activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 256256GTP cyclohydrolase FolE2 HAMAP-Rule MF_01527
PRO_1000215387

Sites

Site1451May be catalytically important By similarity

Sequences

Sequence LengthMass (Da)Tools
C6C0U6 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 857FA7FE6E0DEDDC

FASTA25628,658
        10         20         30         40         50         60 
MEDVQNSPAK VAMSIDRVGV RDLTLPLVVR DRESGSQSTM AKVALSVDLP AHFKGTHMSR 

        70         80         90        100        110        120 
FVEALEDWSE ELDYQSFYNL LSDILRRLEA ERAHAELSFP YCLQKKSPVS GRKGIMSYEC 

       130        140        150        160        170        180 
TVEGEMVGDN LEFTLGVKVP VMTVCPCSKA ISDEGAHSQR AVVHIRTKSK GFVWIEDLVE 

       190        200        210        220        230        240 
IAEASGSCEV FSLLKREDEK HVTEKSFSNP TFVEDVVRNA AMGLEKHSKI LWYQVDVESF 

       250 
ESIHNHCAFA SIAKPK 

« Hide

References

[1]"Complete sequence of Desulfovibrio salexigens DSM 2638."
US DOE Joint Genome Institute
Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Tice H., Bruce D., Goodwin L., Pitluck S., Munk A.C., Brettin T., Detter J.C., Han C., Tapia R., Larimer F., Land M., Hauser L., Kyrpides N., Anderson I. expand/collapse author list , Wall J.D., Arkin A.P., Dehal P., Chivian D., Giles B., Hazen T.C.
Submitted (JUN-2009) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001649 Genomic DNA. Translation: ACS81043.1.
RefSeqYP_002992582.1. NC_012881.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING526222.Desal_2991.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS81043; ACS81043; Desal_2991.
GeneID8093673.
KEGGdsa:Desal_2991.
PATRIC21761541. VBIDesSal121003_2987.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1469.
HOGENOMHOG000280679.
KOK09007.
OMADVQSSRD.
OrthoDBEOG6X6RBH.

Enzyme and pathway databases

BioCycDSAL526222:GHES-3063-MONOMER.
UniPathwayUPA00848; UER00151.

Family and domain databases

HAMAPMF_01527_B. GTP_cyclohydrol_B.
InterProIPR022838. GTP_cyclohydrolase_FolE2.
IPR003801. GTP_cyclohydrolase_FolE2/MptA.
[Graphical view]
PfamPF02649. GCHY-1. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGCH4_DESAD
AccessionPrimary (citable) accession number: C6C0U6
Entry history
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: May 14, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways