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Protein

Protein-L-isoaspartate O-methyltransferase

Gene

pcm

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + protein L-isoaspartate = S-adenosyl-L-homocysteine + protein L-isoaspartate alpha-methyl ester.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei63UniRule annotation1

GO - Molecular functioni

Keywordsi

Molecular functionMethyltransferase, Transferase
LigandS-adenosyl-L-methionine

Names & Taxonomyi

Protein namesi
Recommended name:
Protein-L-isoaspartate O-methyltransferaseUniRule annotation (EC:2.1.1.77UniRule annotation)
Alternative name(s):
L-isoaspartyl protein carboxyl methyltransferaseUniRule annotation
Protein L-isoaspartyl methyltransferaseUniRule annotation
Protein-beta-aspartate methyltransferaseUniRule annotation
Short name:
PIMTUniRule annotation
Gene namesi
Name:pcmUniRule annotation
Ordered Locus Names:Desal_1807
OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Taxonomic identifieri526222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002601 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002026611 – 214Protein-L-isoaspartate O-methyltransferaseAdd BLAST214

Interactioni

Protein-protein interaction databases

STRINGi526222.Desal_1807.

Structurei

3D structure databases

ProteinModelPortaliC6BTT9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiKPIGYNA.
OrthoDBiPOG093N022L.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiView protein in InterPro
IPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiView protein in PROSITE
PS01279. PCMT. 1 hit.

Sequencei

Sequence statusi: Complete.

C6BTT9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRIDPKRSRL KMVEEQIAAR GVADKNVLDA MRRVPRHMFV QDALASRAYS
60 70 80 90 100
DSALPIGEGQ TISQPYIVAV MSELLQIESG HKVLEIGTGS GYQAAVLAEM
110 120 130 140 150
GADVFSVERI RKLFISARKL LFDMRYFNIQ LKLDDGTMGW PENAPYDRII
160 170 180 190 200
VTAGGPEIPQ YLIDQLADPG ILVIPVGGQR RVQRLMLVTK TDGKIETTDM
210
GGCAFVDLVG KQGW
Length:214
Mass (Da):23,678
Last modified:September 1, 2009 - v1
Checksum:i30C1A15DC341A0E4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001649 Genomic DNA. Translation: ACS79869.1.
RefSeqiWP_015851685.1. NC_012881.1.

Genome annotation databases

EnsemblBacteriaiACS79869; ACS79869; Desal_1807.
KEGGidsa:Desal_1807.
PATRICi21759111. VBIDesSal121003_1815.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001649 Genomic DNA. Translation: ACS79869.1.
RefSeqiWP_015851685.1. NC_012881.1.

3D structure databases

ProteinModelPortaliC6BTT9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi526222.Desal_1807.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS79869; ACS79869; Desal_1807.
KEGGidsa:Desal_1807.
PATRICi21759111. VBIDesSal121003_1815.

Phylogenomic databases

eggNOGiENOG4105E26. Bacteria.
COG2518. LUCA.
HOGENOMiHOG000257189.
KOiK00573.
OMAiKPIGYNA.
OrthoDBiPOG093N022L.

Family and domain databases

Gene3Di3.40.50.150. 1 hit.
HAMAPiMF_00090. PIMT. 1 hit.
InterProiView protein in InterPro
IPR000682. PCMT.
IPR029063. SAM-dependent_MTases.
PANTHERiPTHR11579. PTHR11579. 1 hit.
SUPFAMiSSF53335. SSF53335. 1 hit.
TIGRFAMsiTIGR00080. pimt. 1 hit.
PROSITEiView protein in PROSITE
PS01279. PCMT. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiPIMT_DESAD
AccessioniPrimary (citable) accession number: C6BTT9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: February 15, 2017
This is version 40 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.