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Protein

Alanine racemase

Gene

Desal_3305

Organism
Desulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi: D-alanine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes D-alanine from L-alanine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Alanine racemase (Desal_3305), Alanine racemase (Desal_0616)
This subpathway is part of the pathway D-alanine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes D-alanine from L-alanine, the pathway D-alanine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei41Proton acceptor; specific for D-alanineUniRule annotation1
Binding sitei139SubstrateUniRule annotation1
Active sitei273Proton acceptor; specific for L-alanineUniRule annotation1
Binding sitei321Substrate; via amide nitrogenUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIsomeraseUniRule annotationSAAS annotationImported
LigandPyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciDSAL526222:G1GF5-3374-MONOMER
UniPathwayiUPA00042; UER00497

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Desal_3305Imported
OrganismiDesulfovibrio salexigens (strain ATCC 14822 / DSM 2638 / NCIB 8403 / VKM B-1763)Imported
Taxonomic identifieri526222 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaDeltaproteobacteriaDesulfovibrionalesDesulfovibrionaceaeDesulfovibrio
Proteomesi
  • UP000002601 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei41N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Protein-protein interaction databases

STRINGi526222.Desal_3305

Structurei

3D structure databases

ProteinModelPortaliC6BRX2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini252 – 380Ala_racemase_CInterPro annotationAdd BLAST129

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105CJ4 Bacteria
COG0787 LUCA
HOGENOMiHOG000031444
KOiK01775
OMAiWRGPILL
OrthoDBiPOG091H022F

Family and domain databases

Gene3Di2.40.37.10, 2 hits
3.20.20.10, 1 hit
HAMAPiMF_01201 Ala_racemase, 1 hit
InterProiView protein in InterPro
IPR000821 Ala_racemase
IPR009006 Ala_racemase/Decarboxylase_C
IPR011079 Ala_racemase_C
IPR001608 Ala_racemase_N
IPR020622 Ala_racemase_pyridoxalP-BS
IPR029066 PLP-binding_barrel
PfamiView protein in Pfam
PF00842 Ala_racemase_C, 1 hit
PF01168 Ala_racemase_N, 1 hit
PRINTSiPR00992 ALARACEMASE
SMARTiView protein in SMART
SM01005 Ala_racemase_C, 1 hit
SUPFAMiSSF50621 SSF50621, 1 hit
SSF51419 SSF51419, 1 hit
TIGRFAMsiTIGR00492 alr, 1 hit
PROSITEiView protein in PROSITE
PS00395 ALANINE_RACEMASE, 1 hit

Sequencei

Sequence statusi: Complete.

C6BRX2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNNPKTFAPI WAEVDLSAIS HNFSEVQRLV NKQSKIMAVV KADAYGHGLT
60 70 80 90 100
KVADCLNKAG ADYFAVARLD EAVALRNHGI EKPILILGYT PPEAATELLK
110 120 130 140 150
HKVIQTVFSS EYAKDLNEKL NQTNKTLKVH IKIDTGMGRL GLVDEFNDGA
160 170 180 190 200
VLESISTINR LPNLETEGVY THFAASDEAD KTSALEQLKQ FKNILAGIER
210 220 230 240 250
RGISIPLKHA ANSAAIIDLP ESYFDMVRPG IMLYGLYPSN GVHQQNAELR
260 270 280 290 300
PAMQIKARIA QTKEVPAGFR ISYGHTYTTP NATKLATIPL GYADGYRRQL
310 320 330 340 350
SSAGKVLVHG QHASIVGRVC MDQSVIDVGK IENVEAGDEV VIIGRQEQAE
360 370 380
ISAERMACEL GTINYEIVST LMARVPRIFK DS
Length:382
Mass (Da):41,899
Last modified:September 1, 2009 - v1
Checksum:i0975E2390630E382
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001649 Genomic DNA Translation: ACS81355.1
RefSeqiWP_015853171.1, NC_012881.1

Genome annotation databases

EnsemblBacteriaiACS81355; ACS81355; Desal_3305
KEGGidsa:Desal_3305

Similar proteinsi

Entry informationi

Entry nameiC6BRX2_DESAD
AccessioniPrimary (citable) accession number: C6BRX2
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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