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C6BJD4

- C6BJD4_RALP1

UniProt

C6BJD4 - C6BJD4_RALP1

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Protein
Acetyl-coenzyme A synthetase
Gene
acsA, Rpic12D_1775
Organism
Ralstonia pickettii (strain 12D)
Status
Unreviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA By similarity.UniRule annotation

Catalytic activityi

ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei317 – 3171Coenzyme A By similarityUniRule annotation
Binding sitei397 – 3971Substrate; via nitrogen amide By similarityUniRule annotation
Binding sitei512 – 5121Substrate By similarityUniRule annotation
Binding sitei528 – 5281Substrate By similarityUniRule annotation
Active sitei530 – 5301 By similarityUniRule annotation
Binding sitei536 – 5361Coenzyme A By similarityUniRule annotation
Binding sitei539 – 5391Substrate By similarityUniRule annotation
Metal bindingi550 – 5501Magnesium; via carbonyl oxygen By similarityUniRule annotation
Metal bindingi555 – 5551Magnesium; via carbonyl oxygen By similarityUniRule annotation
Binding sitei600 – 6001Coenzyme A By similarityUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: InterPro
  2. ATP binding Source: UniProtKB-KW
  3. acetate-CoA ligase activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. acetyl-CoA biosynthetic process from acetate Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationImported

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRPIC428406:GH9Y-1808-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetyl-coenzyme A synthetaseUniRule annotation (EC:6.2.1.1UniRule annotation)
Short name:
AcCoA synthetaseUniRule annotation
Short name:
AcsUniRule annotation
Alternative name(s):
Acetate--CoA ligase
Acyl-activating enzyme
Gene namesi
Name:acsAUniRule annotation
Ordered Locus Names:Rpic12D_1775Imported
OrganismiRalstonia pickettii (strain 12D)Imported
Taxonomic identifieri428406 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000008208: Chromosome 1

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei625 – 6251N6-acetyllysine By similarityUniRule annotation

Post-translational modificationi

Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme By similarity.UniRule annotation

Keywords - PTMi

AcetylationUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi428406.Rpic12D_1775.

Structurei

3D structure databases

ProteinModelPortaliC6BJD4.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0365.
HOGENOMiHOG000229981.
KOiK01895.
OMAiGGCEAVT.
OrthoDBiEOG68WR2H.

Family and domain databases

HAMAPiMF_01123. Ac_CoA_synth.
InterProiIPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view]
PfamiPF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view]
TIGRFAMsiTIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEiPS00455. AMP_BINDING. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6BJD4-1 [UniParc]FASTAAdd to Basket

« Hide

MAGIESVLQE TRVFNPPESF VKQANIAGMD AYRALCAEAE KDYEGFWARL    50
AHEHLLWHKP FSKVLDESNA PFYKWFEDGE LNASYNCLER NLENGNADKV 100
AIIFETDDGN VSRITYRELH ARVCRFANGL KALGIKKGDR VVIYMPMSVE 150
GIVAMQACAR IGATHSVVFG GFSAKSLQER IVDVGAVALI TADEQMRGGK 200
ALPLKAIADE ALAMEGTGAV KHVIVYRRTN GNVNWVEGRD RAMDEVEAGQ 250
PDTCEVTPVS AEHPLFILYT SGSTGKPKGV QHSTGGYLLW ALLTMQWTFD 300
LKPDDIFWCT ADIGWVTGHS YIAYGPLAAG ATQVVFEGVP TYPNAGRFWD 350
MIQRHKVNTF YTAPTAIRSL IKAAEADEKV HPKQYDLSSL RLLGTVGEPI 400
NPEAWMWYHT NIGGGRCPIV DTFWQTETGG HMMTPLPGAT PLVPGSCTLP 450
LPGIMAAVVD ETGHDVPNGQ GGILVVKRPW PSMIRTIWGD PERFKKSYFP 500
EELGGKLYLA GDGSIRDKET GYFTIMGRID DVLNVSGHRM GTMEIESALV 550
ANPIVAEAAV VGRPDDMTGE AICAFVVLKR ARPDGDEAKQ IANELRNWVG 600
KEIGPIAKPK DIRFGDNLPK TRSGKIMRRL LRSLAKGEDI TQDTSTLENP 650
AILDQLKETR 660
Length:660
Mass (Da):72,595
Last modified:September 1, 2009 - v1
Checksum:i5656BD9158B10654
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001644 Genomic DNA. Translation: ACS63057.1.
RefSeqiYP_002981729.1. NC_012856.1.

Genome annotation databases

EnsemblBacteriaiACS63057; ACS63057; Rpic12D_1775.
GeneIDi8019431.
KEGGirpf:Rpic12D_1775.
PATRICi20242597. VBIRalPic57998_2388.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001644 Genomic DNA. Translation: ACS63057.1 .
RefSeqi YP_002981729.1. NC_012856.1.

3D structure databases

ProteinModelPortali C6BJD4.
ModBasei Search...

Protein-protein interaction databases

STRINGi 428406.Rpic12D_1775.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS63057 ; ACS63057 ; Rpic12D_1775 .
GeneIDi 8019431.
KEGGi rpf:Rpic12D_1775.
PATRICi 20242597. VBIRalPic57998_2388.

Phylogenomic databases

eggNOGi COG0365.
HOGENOMi HOG000229981.
KOi K01895.
OMAi GGCEAVT.
OrthoDBi EOG68WR2H.

Enzyme and pathway databases

BioCyci RPIC428406:GH9Y-1808-MONOMER.

Family and domain databases

HAMAPi MF_01123. Ac_CoA_synth.
InterProi IPR011904. Ac_CoA_lig.
IPR025110. AMP-bd_C.
IPR020845. AMP-binding_CS.
IPR000873. AMP-dep_Synth/Lig.
[Graphical view ]
Pfami PF00501. AMP-binding. 1 hit.
PF13193. AMP-binding_C. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR02188. Ac_CoA_lig_AcsA. 1 hit.
PROSITEi PS00455. AMP_BINDING. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12DImported.

Entry informationi

Entry nameiC6BJD4_RALP1
AccessioniPrimary (citable) accession number: C6BJD4
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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