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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Ralstonia pickettii (strain 12D)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotationSAAS annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotationSAAS annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotationSAAS annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. protein catabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

AcyltransferaseUniRule annotationSAAS annotation, Transferase

Enzyme and pathway databases

BioCyciRPIC428406:GH9Y-1629-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:Rpic12D_1602Imported
OrganismiRalstonia pickettii (strain 12D)Imported
Taxonomic identifieri428406 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaBurkholderialesBurkholderiaceaeRalstonia
ProteomesiUP000008208: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi428406.Rpic12D_1602.

Structurei

3D structure databases

ProteinModelPortaliC6BIW3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
KOiK00684.
OMAiYRQGIFP.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

C6BIW3-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MIAWLDPHDP FPPVDRALGP ESEAPGLLAA SAELSPQRLL IAYRQGIFPW
60 70 80 90 100
YAQGQPVLWW STDPRMVLRP EDFRVSTTFR KTLRRVLDDP AWEIRIDHGF
110 120 130 140 150
RETMVACATT ARPGQHGTWI TEDVIQAYTS LHRRGYAHSV EAWYAGQRVG
160 170 180 190 200
GLYGVALGRM FYGESMFAHR TDASKIALAA LCAFLGGQGV AMIDCQQETE
210 220 230 240
HLASLGGAPV PRAAFLAHVR EAANAPAIVP WHFDKSVLRR WTVRNEQA
Length:248
Mass (Da):27,675
Last modified:September 1, 2009 - v1
Checksum:iEAAE0D0FF453EEA8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001644 Genomic DNA. Translation: ACS62886.1.
RefSeqiWP_012762093.1. NC_012856.1.
YP_002981558.1. NC_012856.1.

Genome annotation databases

EnsemblBacteriaiACS62886; ACS62886; Rpic12D_1602.
GeneIDi8019252.
KEGGirpf:Rpic12D_1602.
PATRICi20242233. VBIRalPic57998_2212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001644 Genomic DNA. Translation: ACS62886.1.
RefSeqiWP_012762093.1. NC_012856.1.
YP_002981558.1. NC_012856.1.

3D structure databases

ProteinModelPortaliC6BIW3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi428406.Rpic12D_1602.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS62886; ACS62886; Rpic12D_1602.
GeneIDi8019252.
KEGGirpf:Rpic12D_1602.
PATRICi20242233. VBIRalPic57998_2212.

Phylogenomic databases

eggNOGiCOG2360.
HOGENOMiHOG000102325.
KOiK00684.
OMAiYRQGIFP.
OrthoDBiEOG6WX4R3.

Enzyme and pathway databases

BioCyciRPIC428406:GH9Y-1629-MONOMER.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 12DImported.

Entry informationi

Entry nameiC6BIW3_RALP1
AccessioniPrimary (citable) accession number: C6BIW3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 4, 2015
This is version 39 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.