ID C6B636_RHILS Unreviewed; 881 AA. AC C6B636; DT 01-SEP-2009, integrated into UniProtKB/TrEMBL. DT 01-SEP-2009, sequence version 1. DT 27-MAR-2024, entry version 78. DE RecName: Full=DNA ligase (ATP) {ECO:0000256|ARBA:ARBA00012727}; DE EC=6.5.1.1 {ECO:0000256|ARBA:ARBA00012727}; DE AltName: Full=NHEJ DNA polymerase {ECO:0000256|ARBA:ARBA00029943}; GN OrderedLocusNames=Rleg_5341 {ECO:0000313|EMBL:ACS59544.1}; OS Rhizobium leguminosarum bv. trifolii (strain WSM1325). OG Plasmid pR132501 {ECO:0000313|EMBL:ACS59544.1, OG ECO:0000313|Proteomes:UP000002256}. OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales; OC Rhizobiaceae; Rhizobium/Agrobacterium group; Rhizobium. OX NCBI_TaxID=395491 {ECO:0000313|EMBL:ACS59544.1, ECO:0000313|Proteomes:UP000002256}; RN [1] {ECO:0000313|EMBL:ACS59544.1, ECO:0000313|Proteomes:UP000002256} RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. RC STRAIN=WSM1325 {ECO:0000313|EMBL:ACS59544.1, RC ECO:0000313|Proteomes:UP000002256}; RC PLASMID=Plasmid pR132501 {ECO:0000313|Proteomes:UP000002256}; RX PubMed=21304718; RA Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K., Tiwari R., RA Copeland A., Nolan M., Han C., Brettin T., Land M., Ovchinikova G., RA Ivanova N., Mavromatis K., Markowitz V., Kyrpides N., Melino V., Denton M., RA Yates R., Howieson J.; RT "Complete genome sequence of Rhizobium leguminosarum bv. trifolii strain RT WSM1325, an effective microsymbiont of annual Mediterranean clovers."; RL Stand. Genomic Sci. 2:347-356(2010). CC -!- CATALYTIC ACTIVITY: CC Reaction=ATP + (deoxyribonucleotide)n-3'-hydroxyl + 5'-phospho- CC (deoxyribonucleotide)m = (deoxyribonucleotide)n+m + AMP + CC diphosphate.; EC=6.5.1.1; Evidence={ECO:0000256|ARBA:ARBA00034003}; CC -!- COFACTOR: CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035; CC Evidence={ECO:0000256|ARBA:ARBA00001936}; CC --------------------------------------------------------------------------- CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms CC Distributed under the Creative Commons Attribution (CC BY 4.0) License CC --------------------------------------------------------------------------- DR EMBL; CP001623; ACS59544.1; -; Genomic_DNA. DR RefSeq; WP_012755642.1; NC_012848.1. DR AlphaFoldDB; C6B636; -. DR KEGG; rlg:Rleg_5341; -. DR HOGENOM; CLU_008325_0_1_5; -. DR OrthoDB; 9802472at2; -. DR Proteomes; UP000002256; Plasmid pR132501. DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW. DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW. DR GO; GO:0003910; F:DNA ligase (ATP) activity; IEA:UniProtKB-EC. DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW. DR GO; GO:0004527; F:exonuclease activity; IEA:UniProtKB-KW. DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW. DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW. DR CDD; cd07906; Adenylation_DNA_ligase_LigD_LigC; 1. DR CDD; cd07971; OBF_DNA_ligase_LigD; 1. DR CDD; cd04862; PaeLigD_Pol_like; 1. DR Gene3D; 3.30.1490.70; -; 1. DR Gene3D; 3.30.470.30; DNA ligase/mRNA capping enzyme; 1. DR Gene3D; 3.90.920.10; DNA primase, PRIM domain; 1. DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1. DR InterPro; IPR012309; DNA_ligase_ATP-dep_C. DR InterPro; IPR012310; DNA_ligase_ATP-dep_cent. DR InterPro; IPR014146; LigD_ligase_dom. DR InterPro; IPR014144; LigD_PE_domain. DR InterPro; IPR014145; LigD_pol_dom. DR InterPro; IPR012340; NA-bd_OB-fold. DR InterPro; IPR014143; NHEJ_ligase_prk. DR InterPro; IPR033651; PaeLigD_Pol-like. DR NCBIfam; TIGR02777; LigD_PE_dom; 1. DR NCBIfam; TIGR02778; ligD_pol; 1. DR NCBIfam; TIGR02779; NHEJ_ligase_lig; 1. DR NCBIfam; TIGR02776; NHEJ_ligase_prk; 1. DR PANTHER; PTHR42705; BIFUNCTIONAL NON-HOMOLOGOUS END JOINING PROTEIN LIGD; 1. DR PANTHER; PTHR42705:SF2; MULTIFUNCTIONAL NON-HOMOLOGOUS END JOINING DNA REPAIR PROTEIN LIGD; 1. DR Pfam; PF04679; DNA_ligase_A_C; 1. DR Pfam; PF01068; DNA_ligase_A_M; 1. DR Pfam; PF13298; LigD_N; 1. DR Pfam; PF21686; LigD_Prim-Pol; 1. DR SUPFAM; SSF56091; DNA ligase/mRNA capping enzyme, catalytic domain; 1. DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1. DR PROSITE; PS50160; DNA_LIGASE_A3; 1. PE 4: Predicted; KW ATP-binding {ECO:0000256|ARBA:ARBA00022840}; KW DNA damage {ECO:0000256|ARBA:ARBA00022763}; KW DNA recombination {ECO:0000256|ARBA:ARBA00023172}; KW DNA repair {ECO:0000256|ARBA:ARBA00023204}; KW DNA-binding {ECO:0000256|ARBA:ARBA00023125}; KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932}; KW Exonuclease {ECO:0000256|ARBA:ARBA00022839}; KW Hydrolase {ECO:0000256|ARBA:ARBA00022801}; KW Ligase {ECO:0000256|ARBA:ARBA00022598, ECO:0000313|EMBL:ACS59544.1}; KW Manganese {ECO:0000256|ARBA:ARBA00023211}; KW Metal-binding {ECO:0000256|ARBA:ARBA00022723}; KW Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268}; KW Nuclease {ECO:0000256|ARBA:ARBA00022722}; KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}; KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695}; KW Plasmid {ECO:0000313|EMBL:ACS59544.1}; KW Transferase {ECO:0000256|ARBA:ARBA00022679}. FT DOMAIN 339..476 FT /note="ATP-dependent DNA ligase family profile" FT /evidence="ECO:0000259|PROSITE:PS50160" FT REGION 1..30 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 224..243 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT REGION 550..573 FT /note="Disordered" FT /evidence="ECO:0000256|SAM:MobiDB-lite" FT COMPBIAS 7..30 FT /note="Basic and acidic residues" FT /evidence="ECO:0000256|SAM:MobiDB-lite" SQ SEQUENCE 881 AA; 97363 MW; 9EBB0C9F594802DF CRC64; MASDKLSTYR SKRDFKKTDE PSGEKRLSRS NRRRFVIQKH DATRLHYDLR LELDGVFKSW AVTKGPSLDP HDKRLAVEVE DHPLDYGDFE GTIPKGQYGG GTVMLWDRGY WEPEGKKSPE QALAKGDFKF TLEGKRLHGS FVLVRMRNDR NGGNRTNWLL IKHHDEFSVE NKGEAVLEEN DTSVASGRTM EMIAGGKGRK PRPFMIEGGD VQADAVWDSN HGLAAEERKD DTGGGRKSKP ATKVDLPDFI APQLCRTLER PPAGTGWLHE IKFDGYRIQM RVLDGEATLK TRKGLDWTAK YPEIAEAAST LPDAIIDGEI CALDDHGAPD FAALQAALSE GKTGELVYFA FDLLYEGGED VRSLPLVERK ARLQSLLSDA GDDPRVRFVE HFDTGGDAVL QSACKLSLEG IVSKEADAPY QSGRTESWAK SKCRSGHEVV IGAYAQTNGK FRSLLVGVYH GDHFVYVGRV GTGYGAKKVE TLLPKLKALE TAKSPFTGIG APKKEAEVIW LKPELVAEIE FAGWTADGIV RQAAFKGLRE DKPAIEVKAE RPAKPAQTDV PQPTVEAKTR PVRKKGAKAE VMGVLISNPD KPLWPDANDG KTVTKEDLAC YYEAVGSWLI EHIKGRPCSI IRTPDGIGGE QFFQRHAMPG TSNLLELVKV FGDKKPYLQI DRIEGLAAVA QIGAVELHPW NCEPRQPEVP GRLVFDLDPG PDVPFSAVVS AAREMRDRLD ALGMISFCKT TGGKGLHVVT PLAINKRKPL SWAEAKGFAH DVCQQMARDN PELYLIKMTK SLRDGRIFLD YLRNDRMATA VAPLSPRARP GATVSMPLTW TQVKSDLDPK RFTIRTVPTL LSKSSAWEDY GDGKRPLEQA IKRLGKVSKV A //