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Protein

Elongation factor Tu

Gene

tuf

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM1325)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis.UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi19 – 268GTPUniRule annotation
Nucleotide bindingi76 – 805GTPUniRule annotation
Nucleotide bindingi131 – 1344GTPUniRule annotation

GO - Molecular functioni

  1. GTPase activity Source: InterPro
  2. GTP binding Source: UniProtKB-HAMAP
  3. translation elongation factor activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Elongation factorUniRule annotationImported

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

GTP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciRLEG395491:GHX2-1429-MONOMER.
RLEG395491:GHX2-1445-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Elongation factor TuUniRule annotation
Short name:
EF-TuUniRule annotation
Gene namesi
Name:tufUniRule annotation
Ordered Locus Names:Rleg_1413Imported, Rleg_1428Imported
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM1325)Imported
Taxonomic identifieri395491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000002256 Componenti: Chromosome

Subcellular locationi

  1. Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi395491.Rleg_1428.

Structurei

3D structure databases

ProteinModelPortaliC6AUY0.
SMRiC6AUY0. Positions 2-390.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.
OrthoDBiEOG6R5C6X.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6AUY0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKSKFERNK PHVNIGTIGH VDHGKTSLTA AITKYFGEYK AYDQIDAAPE
60 70 80 90 100
EKARGITIST AHVEYETPAR HYAHVDCPGH ADYVKNMITG AAQMDGAILV
110 120 130 140 150
CSAADGPMPQ TREHILLARQ VGVPAIVVFL NKVDQVDDAE LLELVELEVR
160 170 180 190 200
ELLSSYDFPG DDIPIVKGSA LAALEDSDKK IGEDSIRELM AAVDAYIPTP
210 220 230 240 250
ERPINLPFLL PIEDVFSISG RGTVVTGRVE RGIVKVGEEV EIVGIRPTTK
260 270 280 290 300
TTVTGVEMFR KLLDQGQAGD NIGALIRGVT RDGVERGQIL CKPGSVKPHK
310 320 330 340 350
KFMAEAYILT KEEGGRHTPF FTNYRPQFYF RTTDVTGIVT LPEGTEMVMP
360 370 380 390
GDNVTVSVEL IVPIAMEEKL RFAIREGGRT VGAGIVASIV E
Length:391
Mass (Da):42,596
Last modified:September 1, 2009 - v1
Checksum:iB55D6BDE0D715A82
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001622 Genomic DNA. Translation: ACS55705.1.
CP001622 Genomic DNA. Translation: ACS55720.1.
RefSeqiYP_002975244.1. NC_012850.1.
YP_002975259.1. NC_012850.1.

Genome annotation databases

EnsemblBacteriaiACS55705; ACS55705; Rleg_1413.
ACS55720; ACS55720; Rleg_1428.
KEGGirlg:Rleg_1413.
rlg:Rleg_1428.
PATRICi23110228. VBIRhiLeg48398_2186.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001622 Genomic DNA. Translation: ACS55705.1.
CP001622 Genomic DNA. Translation: ACS55720.1.
RefSeqiYP_002975244.1. NC_012850.1.
YP_002975259.1. NC_012850.1.

3D structure databases

ProteinModelPortaliC6AUY0.
SMRiC6AUY0. Positions 2-390.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi395491.Rleg_1428.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS55705; ACS55705; Rleg_1413.
ACS55720; ACS55720; Rleg_1428.
KEGGirlg:Rleg_1413.
rlg:Rleg_1428.
PATRICi23110228. VBIRhiLeg48398_2186.

Phylogenomic databases

eggNOGiCOG0050.
HOGENOMiHOG000229290.
KOiK02358.
OMAiDEGGRHN.
OrthoDBiEOG6R5C6X.

Enzyme and pathway databases

BioCyciRLEG395491:GHX2-1429-MONOMER.
RLEG395491:GHX2-1445-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00118_B. EF_Tu_B.
InterProiIPR000795. EF_GTP-bd_dom.
IPR027417. P-loop_NTPase.
IPR005225. Small_GTP-bd_dom.
IPR009000. Transl_B-barrel.
IPR009001. Transl_elong_EF1A/Init_IF2_C.
IPR004161. Transl_elong_EFTu/EF1A_2.
IPR004541. Transl_elong_EFTu/EF1A_bac/org.
IPR004160. Transl_elong_EFTu/EF1A_C.
[Graphical view]
PfamiPF00009. GTP_EFTU. 1 hit.
PF03144. GTP_EFTU_D2. 1 hit.
PF03143. GTP_EFTU_D3. 1 hit.
[Graphical view]
PRINTSiPR00315. ELONGATNFCT.
SUPFAMiSSF50447. SSF50447. 1 hit.
SSF50465. SSF50465. 1 hit.
SSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00485. EF-Tu. 1 hit.
TIGR00231. small_GTP. 1 hit.
PROSITEiPS00301. EFACTOR_GTP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Complete sequence of chromosome of Rhizobium leguminosarum bv. trifolii WSM1325."
    US DOE Joint Genome Institute
    Lucas S., Copeland A., Lapidus A., Glavina del Rio T., Dalin E., Tice H., Bruce D., Goodwin L., Pitluck S., Kiss H., Brettin T., Detter J.C., Han C., Larimer F., Land M., Hauser L., Kyrpides N., Ovchinnikova H., Reeve W.G.
    Submitted (MAY-2009) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: WSM1325Imported.
  2. "Complete genome sequence of Rhizobium leguminosarum bv. trifolii strain WSM1325, an effective microsymbiont of annual Mediterranean clovers."
    Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K., Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M., Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N., Melino V.
    , Denton M., Yates R., Howieson J.
    Stand. Genomic Sci. 2:347-356(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM1325Imported.

Entry informationi

Entry nameiC6AUY0_RHILS
AccessioniPrimary (citable) accession number: C6AUY0
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 29, 2015
This is version 51 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.