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C6AT75

- C6AT75_RHILS

UniProt

C6AT75 - C6AT75_RHILS

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Protein

Thymidine kinase

Gene

tdk

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM1325)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei89 – 891Proton acceptorUniRule annotation
Metal bindingi146 – 1461ZincUniRule annotation
Metal bindingi148 – 1481ZincUniRule annotation
Metal bindingi183 – 1831ZincUniRule annotation
Metal bindingi186 – 1861ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi9 – 168ATPUniRule annotation
Nucleotide bindingi88 – 914ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. thymidine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. DNA biosynthetic process Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding, ZincUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRLEG395491:GHX2-3123-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Rleg_3091Imported
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM1325)Imported
Taxonomic identifieri395491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
ProteomesiUP000002256: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotationSAAS annotation

Protein-protein interaction databases

STRINGi395491.Rleg_3091.

Structurei

3D structure databases

ProteinModelPortaliC6AT75.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1435.
HOGENOMiHOG000076391.
KOiK00857.
OMAiELKTVCH.
OrthoDBiEOG69D3J2.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase.
InterProiIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6AT75-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKLYFNYST MNAGKSTMLL QASYNYQERG MRTVQLIAAF DERAGRGVIG
60 70 80 90 100
SRIGLEASAI PFEPHEDLFR LVATLSGDGA PISCIFVDEA HFMTPVHVWQ
110 120 130 140 150
LARVVDRLGI PVMVYGLRTD FQGKLFPASQ ELLAIADEMR EVRTICHCGR
160 170 180 190 200
KATMVVRLDA KGKVLHEGAQ IDVGGNEKYV SLCRRHWDDA MNGAWIAEPV
Length:200
Mass (Da):22,261
Last modified:September 1, 2009 - v1
Checksum:i3CEB211DE60121D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001622 Genomic DNA. Translation: ACS57347.1.
RefSeqiYP_002976886.1. NC_012850.1.

Genome annotation databases

EnsemblBacteriaiACS57347; ACS57347; Rleg_3091.
GeneIDi8014000.
KEGGirlg:Rleg_3091.
PATRICi23113619. VBIRhiLeg48398_3865.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001622 Genomic DNA. Translation: ACS57347.1 .
RefSeqi YP_002976886.1. NC_012850.1.

3D structure databases

ProteinModelPortali C6AT75.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 395491.Rleg_3091.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS57347 ; ACS57347 ; Rleg_3091 .
GeneIDi 8014000.
KEGGi rlg:Rleg_3091.
PATRICi 23113619. VBIRhiLeg48398_3865.

Phylogenomic databases

eggNOGi COG1435.
HOGENOMi HOG000076391.
KOi K00857.
OMAi ELKTVCH.
OrthoDBi EOG69D3J2.

Enzyme and pathway databases

BioCyci RLEG395491:GHX2-3123-MONOMER.

Family and domain databases

HAMAPi MF_00124. Thymidine_kinase.
InterProi IPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view ]
PANTHERi PTHR11441. PTHR11441. 1 hit.
Pfami PF00265. TK. 1 hit.
[Graphical view ]
PIRSFi PIRSF035805. TK_cell. 1 hit.
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Complete genome sequence of Rhizobium leguminosarum bv. trifolii strain WSM1325, an effective microsymbiont of annual Mediterranean clovers."
    Reeve W., O'Hara G., Chain P., Ardley J., Brau L., Nandesena K., Tiwari R., Copeland A., Nolan M., Han C., Brettin T., Land M., Ovchinikova G., Ivanova N., Mavromatis K., Markowitz V., Kyrpides N., Melino V.
    , Denton M., Yates R., Howieson J.
    Stand. Genomic Sci. 2:347-356(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: WSM1325Imported.

Entry informationi

Entry nameiC6AT75_RHILS
AccessioniPrimary (citable) accession number: C6AT75
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 26, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3