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Protein

Thymidine kinase

Gene

tdk

Organism
Rhizobium leguminosarum bv. trifolii (strain WSM1325)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei89Proton acceptorUniRule annotation1
Metal bindingi146ZincUniRule annotation1
Metal bindingi148ZincUniRule annotation1
Metal bindingi183ZincUniRule annotation1
Metal bindingi186ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi9 – 16ATPUniRule annotation8
Nucleotide bindingi88 – 91ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionKinaseUniRule annotationImported, Transferase
Biological processDNA synthesisUniRule annotation
LigandATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:Rleg_3091Imported
OrganismiRhizobium leguminosarum bv. trifolii (strain WSM1325)Imported
Taxonomic identifieri395491 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesRhizobiaceaeRhizobium/Agrobacterium groupRhizobium
Proteomesi
  • UP000002256 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Structurei

3D structure databases

ProteinModelPortaliC6AT75
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

HOGENOMiHOG000076391
KOiK00857
OMAiKEQFGWI
OrthoDBiPOG091H0659

Family and domain databases

HAMAPiMF_00124 Thymidine_kinase, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR001267 Thymidine_kinase
IPR020633 Thymidine_kinase_CS
PANTHERiPTHR11441 PTHR11441, 1 hit
PfamiView protein in Pfam
PF00265 TK, 1 hit
PIRSFiPIRSF035805 TK_cell, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00603 TK_CELLULAR_TYPE, 1 hit

Sequencei

Sequence statusi: Complete.

C6AT75-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKLYFNYST MNAGKSTMLL QASYNYQERG MRTVQLIAAF DERAGRGVIG
60 70 80 90 100
SRIGLEASAI PFEPHEDLFR LVATLSGDGA PISCIFVDEA HFMTPVHVWQ
110 120 130 140 150
LARVVDRLGI PVMVYGLRTD FQGKLFPASQ ELLAIADEMR EVRTICHCGR
160 170 180 190 200
KATMVVRLDA KGKVLHEGAQ IDVGGNEKYV SLCRRHWDDA MNGAWIAEPV
Length:200
Mass (Da):22,261
Last modified:September 1, 2009 - v1
Checksum:i3CEB211DE60121D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001622 Genomic DNA Translation: ACS57347.1
RefSeqiWP_012758502.1, NC_012850.1

Genome annotation databases

EnsemblBacteriaiACS57347; ACS57347; Rleg_3091
KEGGirlg:Rleg_3091

Similar proteinsi

Entry informationi

Entry nameiC6AT75_RHILS
AccessioniPrimary (citable) accession number: C6AT75
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: March 28, 2018
This is version 58 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported
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Main funding by: National Institutes of Health