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Protein

tRNA pseudouridine synthase B

Gene

truB

Organism
Aggregatibacter aphrophilus (strain NJ8700) (Haemophilus aphrophilus)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs.UniRule annotationSAAS annotation

Catalytic activityi

tRNA uridine(55) = tRNA pseudouridine(55).UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei48 – 481NucleophileUniRule annotation

GO - Molecular functioni

  1. pseudouridine synthase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: InterPro

GO - Biological processi

  1. tRNA pseudouridine synthesis Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Biological processi

tRNA processingUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciAAPH634176:GHVL-951-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA pseudouridine synthase BUniRule annotationSAAS annotation (EC:5.4.99.25UniRule annotationSAAS annotation)
Alternative name(s):
tRNA pseudouridine(55) synthaseUniRule annotation
tRNA pseudouridylate synthaseUniRule annotation
tRNA-uridine isomeraseUniRule annotation
Gene namesi
Name:truBUniRule annotation
Ordered Locus Names:NT05HA_0980Imported
OrganismiAggregatibacter aphrophilus (strain NJ8700) (Haemophilus aphrophilus)Imported
Taxonomic identifieri634176 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeAggregatibacter
ProteomesiUP000002733: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi634176.NT05HA_0980.

Family & Domainsi

Sequence similaritiesi

Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0130.
HOGENOMiHOG000231223.
KOiK03177.
OMAiYELQFIR.
OrthoDBiEOG6358D3.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
HAMAPiMF_01080. TruB_bact.
InterProiIPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR015947. PUA-like_domain.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR015240. tRNA_sdUridine_synth_fam1_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF09157. TruB-C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.

Sequencei

Sequence statusi: Complete.

C6ANE3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKPRKRGRD IHGVFLLDKP QGMSSNDIMQ KVKRIFQANK AGHTGALDPL
60 70 80 90 100
ATGMLPICLG EATKFSQFLL DADKRYLVTA KLGERTDTSD AEGQIVETRE
110 120 130 140 150
VKVKTPEILT ALEQFRGDIL QVPTMFSALK HNGKPLYEYA RQGITVEREA
160 170 180 190 200
RPITIFELNF IEYNAPYLTL EVHCSKGTYI RTLVDDLGEV LGCGAHVTML
210 220 230 240 250
RRTAVADYPT EKMLDWNALQ SLAAQQDLAL LDALLLPMDT AVAKLPTLTL
260 270 280 290 300
DESQAQGIGF GQRVKFNNPN SLQGQVRLFS HENRFLGVAV IDENNVIRPQ

RLVVYE
Length:306
Mass (Da):34,171
Last modified:September 1, 2009 - v1
Checksum:iCEDA55C95C93A923
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001607 Genomic DNA. Translation: ACS97355.1.
RefSeqiYP_003007442.1. NC_012913.1.

Genome annotation databases

EnsemblBacteriaiACS97355; ACS97355; NT05HA_0980.
GeneIDi8122946.
KEGGiaap:NT05HA_0980.
PATRICi31917028. VBIAggAph86045_0925.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001607 Genomic DNA. Translation: ACS97355.1.
RefSeqiYP_003007442.1. NC_012913.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi634176.NT05HA_0980.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS97355; ACS97355; NT05HA_0980.
GeneIDi8122946.
KEGGiaap:NT05HA_0980.
PATRICi31917028. VBIAggAph86045_0925.

Phylogenomic databases

eggNOGiCOG0130.
HOGENOMiHOG000231223.
KOiK03177.
OMAiYELQFIR.
OrthoDBiEOG6358D3.

Enzyme and pathway databases

BioCyciAAPH634176:GHVL-951-MONOMER.

Family and domain databases

Gene3Di2.30.130.10. 1 hit.
HAMAPiMF_01080. TruB_bact.
InterProiIPR002501. PsdUridine_synth.
IPR020103. PsdUridine_synth_cat_dom.
IPR015947. PUA-like_domain.
IPR014780. tRNA_psdUridine_synth_TruB.
IPR015240. tRNA_sdUridine_synth_fam1_C.
[Graphical view]
PANTHERiPTHR13767. PTHR13767. 1 hit.
PfamiPF09157. TruB-C_2. 1 hit.
PF01509. TruB_N. 1 hit.
[Graphical view]
SUPFAMiSSF55120. SSF55120. 1 hit.
SSF88697. SSF88697. 1 hit.
TIGRFAMsiTIGR00431. TruB. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Complete genome sequence of Aggregatibacter (Haemophilus) aphrophilus NJ8700."
    Di Bonaventura M.P., DeSalle R., Pop M., Nagarajan N., Figurski D.H., Fine D.H., Kaplan J.B., Planet P.J.
    J. Bacteriol. 191:4693-4694(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: NJ8700Imported.

Entry informationi

Entry nameiC6ANE3_AGGAN
AccessioniPrimary (citable) accession number: C6ANE3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: March 4, 2015
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.