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C6AGU9

- C6AGU9_BIFAS

UniProt

C6AGU9 - C6AGU9_BIFAS

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Protein

D-alanine--D-alanine ligase

Gene

ddl

Organism
Bifidobacterium animalis subsp. lactis (strain DSM 10140 / JCM 10602 / LMG 18314)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cell wall formation.UniRule annotationSAAS annotation

Catalytic activityi

ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine.UniRule annotationSAAS annotation

Cofactori

Binds 2 magnesium or manganese ions per subunit.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi328 – 3281Magnesium or manganese 1UniRule annotation
Metal bindingi341 – 3411Magnesium or manganese 1UniRule annotation
Metal bindingi341 – 3411Magnesium or manganese 2UniRule annotation
Metal bindingi343 – 3431Magnesium or manganese 2UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi189 – 24759ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. D-alanine-D-alanine ligase activity Source: UniProtKB-HAMAP
  3. magnesium ion binding Source: UniProtKB-HAMAP
  4. manganese ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. cell wall organization Source: UniProtKB-KW
  2. peptidoglycan biosynthetic process Source: UniProtKB-HAMAP
  3. regulation of cell shape Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

LigaseUniRule annotationSAAS annotation

Keywords - Biological processi

Cell shape, Cell wall biogenesis/degradationUniRule annotationSAAS annotation, Peptidoglycan synthesisUniRule annotationSAAS annotation

Keywords - Ligandi

ATP-bindingUniRule annotationSAAS annotation, MagnesiumUniRule annotationSAAS annotation, ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBANI555970:GJ22-248-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
D-alanine--D-alanine ligaseUniRule annotation (EC:6.3.2.4UniRule annotation)
Alternative name(s):
D-Ala-D-Ala ligaseUniRule annotation
D-alanylalanine synthetaseUniRule annotation
Gene namesi
Name:ddlUniRule annotation
Ordered Locus Names:Balat_0248Imported
OrganismiBifidobacterium animalis subsp. lactis (strain DSM 10140 / JCM 10602 / LMG 18314)Imported
Taxonomic identifieri555970 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000009076: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi555970.Balat_0248.

Structurei

3D structure databases

ProteinModelPortaliC6AGU9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini149 – 374226ATP-graspUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the D-alanine--D-alanine ligase family.UniRule annotation
Contains 1 ATP-grasp domain.UniRule annotation
Contains ATP-grasp domain.SAAS annotation

Phylogenomic databases

eggNOGiCOG1181.
HOGENOMiHOG000011593.
KOiK01921.
OMAiQIDVIFP.
OrthoDBiEOG64BQ73.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPiMF_00047. Dala_Dala_lig.
InterProiIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view]
PANTHERiPTHR23132. PTHR23132. 1 hit.
PfamiPF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view]
SUPFAMiSSF52440. SSF52440. 1 hit.
TIGRFAMsiTIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEiPS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6AGU9-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAKTRVAVLY GGKADEHSIS CISAASFMRA LDPELFEAVP IGITKTGTWF
60 70 80 90 100
VDGQDPLGWN LAEGLPEAVE TPDSREVVLT IGDGGDGFHA RNADGSLDSL
110 120 130 140 150
GHIDVVLPAL HGPFGEDGTI QGLFEMMGVP YVGCGVLASA ACMDKHYTKV
160 170 180 190 200
LLRAAGIPVA PGITLDTRHY DASDEFATDG EEFLRQVNEA GLQYPLFVKP
210 220 230 240 250
SRAGSSFGVT KVEQIGDAAA LAAAVFEASR HDWRVLVEQG IDAREIECAV
260 270 280 290 300
VRIHPTDPTR AALPGEVVLD RRSEGDDQFY DFDSKYMDSQ ASHTEIPAKI
310 320 330 340 350
GDDLIARVRE TAVRAFDAVD GMGLSRVDTF VTADGDVLVN EINTLPGCTS
360 370
ISMFPQAWEA MGIPFRTVVT DLIEGALA
Length:378
Mass (Da):40,445
Last modified:September 1, 2009 - v1
Checksum:i23FCACC423C71CB1
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001606 Genomic DNA. Translation: ACS47206.1.
RefSeqiYP_002969268.1. NC_012815.1.

Genome annotation databases

EnsemblBacteriaiACS47206; ACS47206; Balat_0248.
GeneIDi8009870.
KEGGiblt:Balat_0248.
PATRICi21110026. VBIBifAni93544_0251.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001606 Genomic DNA. Translation: ACS47206.1 .
RefSeqi YP_002969268.1. NC_012815.1.

3D structure databases

ProteinModelPortali C6AGU9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 555970.Balat_0248.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS47206 ; ACS47206 ; Balat_0248 .
GeneIDi 8009870.
KEGGi blt:Balat_0248.
PATRICi 21110026. VBIBifAni93544_0251.

Phylogenomic databases

eggNOGi COG1181.
HOGENOMi HOG000011593.
KOi K01921.
OMAi QIDVIFP.
OrthoDBi EOG64BQ73.

Enzyme and pathway databases

UniPathwayi UPA00219 .
BioCyci BANI555970:GJ22-248-MONOMER.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
HAMAPi MF_00047. Dala_Dala_lig.
InterProi IPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR000291. D-Ala_lig_Van_CS.
IPR005905. D_ala_D_ala.
IPR011095. Dala_Dala_lig_C.
IPR011127. Dala_Dala_lig_N.
IPR016185. PreATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR23132. PTHR23132. 1 hit.
Pfami PF07478. Dala_Dala_lig_C. 1 hit.
PF01820. Dala_Dala_lig_N. 1 hit.
[Graphical view ]
SUPFAMi SSF52440. SSF52440. 1 hit.
TIGRFAMsi TIGR01205. D_ala_D_alaTIGR. 1 hit.
PROSITEi PS50975. ATP_GRASP. 1 hit.
PS00843. DALA_DALA_LIGASE_1. 1 hit.
PS00844. DALA_DALA_LIGASE_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: DSM 10140 / JCM 10602 / LMG 18314Imported.

Entry informationi

Entry nameiC6AGU9_BIFAS
AccessioniPrimary (citable) accession number: C6AGU9
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 37 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3