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C6ABH0 (C6ABH0_BARGA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 36. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Gamma-glutamyl phosphate reductase HAMAP-Rule MF_00412

Short name=GPR HAMAP-Rule MF_00412
EC=1.2.1.41 HAMAP-Rule MF_00412
Alternative name(s):
Glutamate-5-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Glutamyl-gamma-semialdehyde dehydrogenase HAMAP-Rule MF_00412
Gene names
Name:proA HAMAP-Rule MF_00412 EMBL ACS50537.1
Ordered Locus Names:Bgr_01670 EMBL ACS50537.1
OrganismBartonella grahamii (strain as4aup) [Complete proteome] [HAMAP] EMBL ACS50537.1
Taxonomic identifier634504 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH dependent reduction of L-gamma-glutamyl 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate By similarity. HAMAP-Rule MF_00412 SAAS SAAS000965

Catalytic activity

L-glutamate 5-semialdehyde + phosphate + NADP+ = L-glutamyl 5-phosphate + NADPH. HAMAP-Rule MF_00412 SAAS SAAS000965

Pathway

Amino-acid biosynthesis; L-proline biosynthesis; L-glutamate 5-semialdehyde from L-glutamate: step 2/2. HAMAP-Rule MF_00412 SAAS SAAS000965

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00412 SAAS SAAS000965.

Sequence similarities

Belongs to the gamma-glutamyl phosphate reductase family. HAMAP-Rule MF_00412

Sequences

Sequence LengthMass (Da)Tools
C6ABH0 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 7A60CBBDCD074797

FASTA41244,556
        10         20         30         40         50         60 
MKDMGQKARY AAAALAVASS EQKNNALEMI ALSLEAQSDE ILRANCQDLE NAAQNNLKAA 

        70         80         90        100        110        120 
MIDRLKLDDL RLRAMIDSVR QVARLSDPVG QVMSAWKRPN GLHISRVRTP LGVIGIIYES 

       130        140        150        160        170        180 
RPNVTVDASS LCLKAGNAAI LRGGSDSFHS SHALHVALVQ GLERSGLPKD AIQIVRTTDR 

       190        200        210        220        230        240 
AAVGEMLKGL DGAIDVIVPR GGKSLVARVQ SDARVPIFAH LEGLCHIYID KSADLAMARN 

       250        260        270        280        290        300 
IVLNAKLRRT GICGAVETVL IDSQALKKFL PVLTALQEKG CEIRATEDIV FLMPDVKLAS 

       310        320        330        340        350        360 
EEDWSHEYLD AILSVKTVEG VEGAISHIKR YSSGHTESII AEDLEVVKNF FNHLDSAILL 

       370        380        390        400        410 
HNASTQFADG GEFGFGMEIG IATGKMHARG PIGVEQLTSF QYHVKGNGQV RA 

« Hide

References

[1]"Run-off replication of host-adaptability genes is associated with gene transfer agents in the genome of mouse-infecting Bartonella grahamii."
Berglund E.C., Frank A.C., Calteau A., Vinnere Pettersson O., Granberg F., Eriksson A.S., Naslund K., Holmberg M., Lindroos H., Andersson S.G.
PLoS Genet. 5:E1000546-E1000546(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: as4aup.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP001562 Genomic DNA. Translation: ACS50537.1.
RefSeqYP_002971214.1. NC_012846.1.

3D structure databases

ProteinModelPortalC6ABH0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING634504.Bgr_01670.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaACS50537; ACS50537; Bgr_01670.
GeneID7997143.
KEGGbgr:Bgr_01670.
PATRIC20539448. VBIBarGra67450_0183.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0014.
HOGENOMHOG000246356.
KOK00147.
OMACNAIETL.
OrthoDBEOG6FFSCX.
ProtClustDBPRK00197.

Enzyme and pathway databases

BioCycBGRA634504:GJI6-167-MONOMER.
UniPathwayUPA00098; UER00360.

Family and domain databases

Gene3D3.40.309.10. 1 hit.
3.40.605.10. 2 hits.
HAMAPMF_00412. ProA.
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR000965. G-glutamylP_reductase.
IPR020593. G-glutamylP_reductase_CS.
IPR012134. Glu-5-SA_DH.
[Graphical view]
PANTHERPTHR11063:SF1. PTHR11063:SF1. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
PIRSFPIRSF000151. GPR. 1 hit.
SUPFAMSSF53720. SSF53720. 1 hit.
TIGRFAMsTIGR00407. proA. 1 hit.
PROSITEPS01223. PROA. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameC6ABH0_BARGA
AccessionPrimary (citable) accession number: C6ABH0
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 16, 2014
This is version 36 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)