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Protein

2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase

Gene

dapD

Organism
Bartonella grahamii (strain as4aup)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

Succinyl-CoA + (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate.UniRule annotationSAAS annotation

Pathwayi: L-lysine biosynthesis via DAP pathway

This protein is involved in step 1 of the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route).UniRule annotationSAAS annotation
Proteins known to be involved in the 3 steps of the subpathway in this organism are:
  1. 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase (dapD)
  2. no protein annotated in this organism
  3. Succinyl-diaminopimelate desuccinylase (dapE)
This subpathway is part of the pathway L-lysine biosynthesis via DAP pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes LL-2,6-diaminopimelate from (S)-tetrahydrodipicolinate (succinylase route), the pathway L-lysine biosynthesis via DAP pathway and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei109SubstrateUniRule annotation1
Binding sitei146SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAcyltransferaseUniRule annotationSAAS annotation, Transferase
Biological processAmino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBGRA634504:G1GV9-68-MONOMER.
UniPathwayiUPA00034; UER00019.

Names & Taxonomyi

Protein namesi
Recommended name:
2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferaseUniRule annotation (EC:2.3.1.117UniRule annotation)
Alternative name(s):
Tetrahydrodipicolinate N-succinyltransferaseUniRule annotation
Short name:
THDP succinyltransferaseUniRule annotation
Short name:
THP succinyltransferaseUniRule annotation
Short name:
Tetrahydropicolinate succinylaseUniRule annotation
Gene namesi
Name:dapDUniRule annotationImported
Ordered Locus Names:Bgr_00690Imported
OrganismiBartonella grahamii (strain as4aup)Imported
Taxonomic identifieri634504 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000001489 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotrimer.UniRule annotation

Protein-protein interaction databases

STRINGi634504.Bgr_00690.

Structurei

3D structure databases

ProteinModelPortaliC6AB89.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 72THDPS_N_2InterPro annotationAdd BLAST67

Sequence similaritiesi

Belongs to the transferase hexapeptide repeat family.UniRule annotationSAAS annotation

Keywords - Domaini

RepeatUniRule annotationSAAS annotation

Phylogenomic databases

eggNOGiENOG4105DMJ. Bacteria.
COG2171. LUCA.
HOGENOMiHOG000003295.
KOiK00674.
OMAiQVPCALI.
OrthoDBiPOG091H0G02.

Family and domain databases

Gene3Di1.10.166.10. 1 hit.
HAMAPiMF_00811. DapD. 1 hit.
InterProiView protein in InterPro
IPR005664. DapD_Trfase_Hexpep_rpt_fam.
IPR001451. Hexapep.
IPR023180. THP_succinylTrfase_dom1.
IPR037133. THP_succinylTrfase_N_sf.
IPR011004. Trimer_LpxA-like_sf.
PfamiView protein in Pfam
PF00132. Hexapep. 1 hit.
PF14602. Hexapep_2. 1 hit.
PF14805. THDPS_N_2. 1 hit.
SUPFAMiSSF51161. SSF51161. 1 hit.
TIGRFAMsiTIGR00965. dapD. 1 hit.

Sequencei

Sequence statusi: Complete.

C6AB89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTHLTQLEMI IQQAFDDRDS IDTTTKGEIR ESIEHTLNLL DKGEIRVAER
60 70 80 90 100
QKNGQWHVHQ WLKKAVLLSF RLNPMQIITG GINGTHWWDK VPSKFSGWQE
110 120 130 140 150
ADFKSADFRS VPGAIVRHSA YIAPNVILMP SFVNLGAFID EGTMVDTWTT
160 170 180 190 200
VGSCAQIGKH VHLSGGVGIG GVLEPLQANP TIIEDHCFIG ARSEIVEGCI
210 220 230 240 250
IREGTVLGMG VFIGKSTKII DRTTGEIFIG EVPAYSVVVP GSFPGKPLPN
260 270 280
GEAGPSLYCA VIVKRVDQKT REKTSINDLL RS
Length:282
Mass (Da):30,944
Last modified:September 1, 2009 - v1
Checksum:iED1DB67019F03410
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001562 Genomic DNA. Translation: ACS50456.1.
RefSeqiWP_012754494.1. NC_012846.1.

Genome annotation databases

EnsemblBacteriaiACS50456; ACS50456; Bgr_00690.
KEGGibgr:Bgr_00690.

Similar proteinsi

Entry informationi

Entry nameiC6AB89_BARGA
AccessioniPrimary (citable) accession number: C6AB89
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: February 28, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported