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Protein

Coenzyme A biosynthesis bifunctional protein CoaBC

Gene

dfp

Organism
Bartonella grahamii (strain as4aup)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.UniRule annotation

Catalytic activityi

CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + N-((R)-4'-phosphopantothenoyl)-L-cysteine.UniRule annotation
N-((R)-4'-phosphopantothenoyl)-L-cysteine = pantotheine 4'-phosphate + CO2.UniRule annotation

Cofactori

FMNUniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 2 and 3 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. Pantothenate kinase (coaA)
  2. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  3. Coenzyme A biosynthesis bifunctional protein CoaBC (dfp)
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. Dephospho-CoA kinase (coaE)
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDecarboxylaseUniRule annotation, LigaseUniRule annotation, Lyase
LigandFlavoprotein, FMNUniRule annotation

Enzyme and pathway databases

UniPathwayiUPA00241; UER00353.
UPA00241; UER00354.

Names & Taxonomyi

Protein namesi
Recommended name:
Coenzyme A biosynthesis bifunctional protein CoaBCUniRule annotation (EC:4.1.1.36UniRule annotation, EC:6.3.2.5UniRule annotation)
Alternative name(s):
DNA/pantothenate metabolism flavoproteinUniRule annotation
Gene namesi
Name:dfpImported
Ordered Locus Names:Bgr_00350Imported
OrganismiBartonella grahamii (strain as4aup)Imported
Taxonomic identifieri634504 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
Proteomesi
  • UP000001489 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi634504.Bgr_00350.

Structurei

3D structure databases

ProteinModelPortaliC6AB60.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini61 – 233FlavoproteinInterPro annotationAdd BLAST173
Domaini243 – 429DFPInterPro annotationAdd BLAST187

Sequence similaritiesi

In the C-terminal section; belongs to the PPC synthetase family.UniRule annotation
In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CJS. Bacteria.
COG0452. LUCA.
HOGENOMiHOG000037526.
KOiK13038.
OMAiVRFIGNH.
OrthoDBiPOG091H021V.

Family and domain databases

Gene3Di1.10.1220.10. 1 hit.
3.40.50.10300. 1 hit.
3.40.50.1950. 1 hit.
InterProiView protein in InterPro
IPR013321. Arc_rbn_hlx_hlx.
IPR005252. CoaBC.
IPR007085. DNA/pantothenate-metab_flavo_C.
IPR003382. Flavoprotein.
IPR010985. Ribbon_hlx_hlx.
PfamiView protein in Pfam
PF04127. DFP. 1 hit.
PF02441. Flavoprotein. 1 hit.
SUPFAMiSSF102645. SSF102645. 1 hit.
SSF47598. SSF47598. 1 hit.
SSF52507. SSF52507. 1 hit.
TIGRFAMsiTIGR00521. coaBC_dfp. 1 hit.

Sequencei

Sequence statusi: Complete.

C6AB60-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASITIRNLS PETKEALRIR AAQNGISMEE EVRRLLSNPT PFTTQPSHTS
60 70 80 90 100
AVEVQSLKSK SLLLIIGGSI ASYKALDLIR RLQERGAHLK VVMTKAAQKF
110 120 130 140 150
ITPLAAEALS GGTVYTDLFS REEEHDIGHI RLARNADLII LAPATANRIA
160 170 180 190 200
KIANGIGDDL ADCILLAARC PLLIAPAMNP SMWAHSATIR NVAQLRADGV
210 220 230 240 250
HIIGPEIGNM AERDEIGYGR MSEPLTIVAT IEALLNVHEK PLSDRHFIVT
260 270 280 290 300
SGPTHEPIDP VRYLANRSSG KQGHAIATAL AHLGAKVTLI CGPVNLADPQ
310 320 330 340 350
EVKTIHVETA QQMLQAVQTA LPADGAIFVA AVCDWRSQTQ SLHKIKKNAH
360 370 380 390 400
KIPPSLHMVE NPDILATIGH APNRPSLVIG FAAETCDIIA NAQKKCVEKG
410 420 430 440 450
ADFILANDIS LQLDGTSVMG ADTNQVYLVS KEKVEQWPHM SKQHVAQKLA
460 470
NMIVSFFAPQ TPTPHEENIP HFK
Length:473
Mass (Da):51,276
Last modified:September 1, 2009 - v1
Checksum:i8DE803197F2805C4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001562 Genomic DNA. Translation: ACS50427.1.
RefSeqiWP_012754466.1. NC_012846.1.

Genome annotation databases

EnsemblBacteriaiACS50427; ACS50427; Bgr_00350.
KEGGibgr:Bgr_00350.

Similar proteinsi

Entry informationi

Entry nameiC6AB60_BARGA
AccessioniPrimary (citable) accession number: C6AB60
Entry historyiIntegrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: September 27, 2017
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported