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C6AB48

- C6AB48_BARGA

UniProt

C6AB48 - C6AB48_BARGA

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Protein

Lysine--tRNA ligase

Gene
lysS, Bgr_00230
Organism
Bartonella grahamii (strain as4aup)
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei307 – 3071ATP By similarityUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

Keywords - Biological processi

Protein biosynthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciBGRA634504:GJI6-23-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetase
Gene namesi
Name:lysSUniRule annotationImported
Ordered Locus Names:Bgr_00230Imported
OrganismiBartonella grahamii (strain as4aup)Imported
Taxonomic identifieri634504 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
ProteomesiUP000001489: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi634504.Bgr_00230.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi54 – 629"HIGH" region By similarityUniRule annotation
Motifi304 – 3085"KMSKS" region By similarityUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1384.
HOGENOMiHOG000140447.
KOiK04566.
OMAiTMVRHAF.
OrthoDBiEOG6WHNM6.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6AB48-1 [UniParc]FASTAAdd to Basket

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MMRDQCDTLN LTPELKDAAS QSRTWPFEEA RKIIKRYEKT GYPDSVIFET    50
GYGPSGLPHI GTFGEVARTT MVRHAFHILT ENKVKTKLLC FSDDMDGLRK 100
VPENVPDRER MEHYLGQPLS RVPDPFGDDY PSFGAANNAR LRAFLDRFGF 150
DYEFASATDY YHSGRFDETL LKILACYDKV MAIILPTLGA ERQATYSLFL 200
PISPFSGKVL QVPMIERNVE KGTVTYIEPE TGETIETEVT GGKVKCQWKV 250
DWAMRWTALG IDYEMAGKDL IDSTNLSSKI CKVLGGKSPE GFNYELFLDE 300
KGQKISKSKG NGLTIDEWLT YAPTESLGLY MFSKPKTAKR LYFDVIPKAV 350
DEYYAHLSAY GRQEWKERLN NPVWHIHNGC PPQVDLPVSF AMLLNLVSAS 400
NAENAEVLWG FISRYAKGAN AQTYPELDQL VKFAIRYFDV FVKPNKKFRL 450
PDESERTTLA QIDEKLANLP ETVDGNMLQN MLLDVARLTE RYQDHSKKSP 500
EGGPGVSNVF FQMLYEVLLG QERGPRWGSF IALYGINEMR ALIAEALARP 550
TEE 553
Length:553
Mass (Da):62,758
Last modified:September 1, 2009 - v1
Checksum:iDC3F6BCAFB72927E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001562 Genomic DNA. Translation: ACS50415.1.
RefSeqiYP_002971092.1. NC_012846.1.

Genome annotation databases

EnsemblBacteriaiACS50415; ACS50415; Bgr_00230.
GeneIDi7996999.
KEGGibgr:Bgr_00230.
PATRICi20539126. VBIBarGra67450_0026.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001562 Genomic DNA. Translation: ACS50415.1 .
RefSeqi YP_002971092.1. NC_012846.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 634504.Bgr_00230.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS50415 ; ACS50415 ; Bgr_00230 .
GeneIDi 7996999.
KEGGi bgr:Bgr_00230.
PATRICi 20539126. VBIBarGra67450_0026.

Phylogenomic databases

eggNOGi COG1384.
HOGENOMi HOG000140447.
KOi K04566.
OMAi TMVRHAF.
OrthoDBi EOG6WHNM6.

Enzyme and pathway databases

BioCyci BGRA634504:GJI6-23-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00177. Lys_tRNA_synth_class1.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01921. tRNA-synt_1f. 1 hit.
[Graphical view ]
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Run-off replication of host-adaptability genes is associated with gene transfer agents in the genome of mouse-infecting Bartonella grahamii."
    Berglund E.C., Frank A.C., Calteau A., Vinnere Pettersson O., Granberg F., Eriksson A.S., Naslund K., Holmberg M., Lindroos H., Andersson S.G.
    PLoS Genet. 5:E1000546-E1000546(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: as4aup.

Entry informationi

Entry nameiC6AB48_BARGA
AccessioniPrimary (citable) accession number: C6AB48
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 11, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome

External Data

Dasty 3

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