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C6AB48

- C6AB48_BARGA

UniProt

C6AB48 - C6AB48_BARGA

Protein

Lysine--tRNA ligase

Gene

lysS

Organism
Bartonella grahamii (strain as4aup)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei307 – 3071ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetaseUniRule annotationImported, Ligase

    Keywords - Biological processi

    Protein biosynthesisUniRule annotation

    Keywords - Ligandi

    ATP-bindingUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciBGRA634504:GJI6-23-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligaseUniRule annotation (EC:6.1.1.6UniRule annotation)
    Alternative name(s):
    Lysyl-tRNA synthetaseUniRule annotation
    Gene namesi
    Name:lysSUniRule annotationImported
    Ordered Locus Names:Bgr_00230Imported
    OrganismiBartonella grahamii (strain as4aup)Imported
    Taxonomic identifieri634504 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBartonellaceaeBartonella
    ProteomesiUP000001489: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi634504.Bgr_00230.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi54 – 629"HIGH" regionUniRule annotation
    Motifi304 – 3085"KMSKS" regionUniRule annotation

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1384.
    HOGENOMiHOG000140447.
    KOiK04566.
    OMAiTMVRHAF.
    OrthoDBiEOG6WHNM6.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00177. Lys_tRNA_synth_class1.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01921. tRNA-synt_1f. 1 hit.
    [Graphical view]
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    C6AB48-1 [UniParc]FASTAAdd to Basket

    « Hide

    MMRDQCDTLN LTPELKDAAS QSRTWPFEEA RKIIKRYEKT GYPDSVIFET    50
    GYGPSGLPHI GTFGEVARTT MVRHAFHILT ENKVKTKLLC FSDDMDGLRK 100
    VPENVPDRER MEHYLGQPLS RVPDPFGDDY PSFGAANNAR LRAFLDRFGF 150
    DYEFASATDY YHSGRFDETL LKILACYDKV MAIILPTLGA ERQATYSLFL 200
    PISPFSGKVL QVPMIERNVE KGTVTYIEPE TGETIETEVT GGKVKCQWKV 250
    DWAMRWTALG IDYEMAGKDL IDSTNLSSKI CKVLGGKSPE GFNYELFLDE 300
    KGQKISKSKG NGLTIDEWLT YAPTESLGLY MFSKPKTAKR LYFDVIPKAV 350
    DEYYAHLSAY GRQEWKERLN NPVWHIHNGC PPQVDLPVSF AMLLNLVSAS 400
    NAENAEVLWG FISRYAKGAN AQTYPELDQL VKFAIRYFDV FVKPNKKFRL 450
    PDESERTTLA QIDEKLANLP ETVDGNMLQN MLLDVARLTE RYQDHSKKSP 500
    EGGPGVSNVF FQMLYEVLLG QERGPRWGSF IALYGINEMR ALIAEALARP 550
    TEE 553
    Length:553
    Mass (Da):62,758
    Last modified:September 1, 2009 - v1
    Checksum:iDC3F6BCAFB72927E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001562 Genomic DNA. Translation: ACS50415.1.
    RefSeqiYP_002971092.1. NC_012846.1.

    Genome annotation databases

    EnsemblBacteriaiACS50415; ACS50415; Bgr_00230.
    GeneIDi7996999.
    KEGGibgr:Bgr_00230.
    PATRICi20539126. VBIBarGra67450_0026.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001562 Genomic DNA. Translation: ACS50415.1 .
    RefSeqi YP_002971092.1. NC_012846.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 634504.Bgr_00230.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS50415 ; ACS50415 ; Bgr_00230 .
    GeneIDi 7996999.
    KEGGi bgr:Bgr_00230.
    PATRICi 20539126. VBIBarGra67450_0026.

    Phylogenomic databases

    eggNOGi COG1384.
    HOGENOMi HOG000140447.
    KOi K04566.
    OMAi TMVRHAF.
    OrthoDBi EOG6WHNM6.

    Enzyme and pathway databases

    BioCyci BGRA634504:GJI6-23-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00177. Lys_tRNA_synth_class1.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01921. tRNA-synt_1f. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Run-off replication of host-adaptability genes is associated with gene transfer agents in the genome of mouse-infecting Bartonella grahamii."
      Berglund E.C., Frank A.C., Calteau A., Vinnere Pettersson O., Granberg F., Eriksson A.-S., Naeslund K., Holmberg M., Lindroos H., Andersson S.G.
      PLoS Genet. 5:E1000546-E1000546(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: as4aupImported.

    Entry informationi

    Entry nameiC6AB48_BARGA
    AccessioniPrimary (citable) accession number: C6AB48
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 42 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3