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C6A7Z8 (C6A7Z8_BIFLB) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 17. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase HAMAP MF_00172
EC=2.1.1.14 HAMAP MF_00172
Alternative name(s):
Cobalamin-independent methionine synthase HAMAP MF_00172
Methionine synthase, vitamin-B12 independent isozyme HAMAP MF_00172
Gene names
Name:metE HAMAP MF_00172
Ordered Locus Names:Balac_0884
OrganismBifidobacterium animalis subsp. lactis (strain Bl-04 / DGCC2908 / RB 4825 / SD5219) [Complete proteome] [HAMAP]
Taxonomic identifier580050 [NCBI]
Taxonomic lineageBacteria › Actinobacteria › Actinobacteridae › Bifidobacteriales › Bifidobacteriaceae › Bifidobacterium

Protein attributes

Sequence length767 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation By similarity. HAMAP MF_00172 SAAS SAAS013215

Catalytic activity

5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine. HAMAP MF_00172 SAAS SAAS013215

Cofactor

Binds 1 zinc ion per subunit By similarity. HAMAP MF_00172

Pathway

Amino-acid biosynthesis; L-methionine biosynthesis via de novo pathway; L-methionine from L-homocysteine (MetE route): step 1/1. HAMAP MF_00172 SAAS SAAS013215

Sequence similarities

Belongs to the vitamin-B12 independent methionine synthase family. HAMAP MF_00172

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Metal binding6531Zinc By similarity HAMAP MF_00172
Metal binding6551Zinc By similarity HAMAP MF_00172
Metal binding7381Zinc By similarity HAMAP MF_00172

Sequences

Sequence LengthMass (Da)Tools
C6A7Z8 [UniParc].

Last modified September 1, 2009. Version 1.
Checksum: 97D9FF6BC9E8A966

FASTA76786,711
        10         20         30         40         50         60 
MTIPTSISGF PRIGRDRELK KAIEAYWKGN ATLDDVRETG RELRVRHWRL EKDAGIDLIP 

        70         80         90        100        110        120 
SNDFSLYDQM LDTAVLLNVI PARYRRLGFD NPEETLFAMA RGYQGERGDV TALPMKKWFT 

       130        140        150        160        170        180 
TNYHYLVPEF DSSTEVRLNG TKPFDEYLEA KSLGIETKPV LIGPYTFLKL SRDAEAQELT 

       190        200        210        220        230        240 
IDEGLVDAVA DVYAEVLRRF AKLGAQWVQL DEPYLVLDKH EGDVSLFKSL YSRLLPARDS 

       250        260        270        280        290        300 
GVRVLLNTYF GNIADIYETV KLFEFDGVGL DLIEGRDENL KAVEHHGVAA RTTLFAGVVN 

       310        320        330        340        350        360 
GRNIWRNNYA ESIALVEALQ QVTANVAVAS ACSLLHVPFS TKGEEQLGDK VLRHFAFAVE 

       370        380        390        400        410        420 
KLEEVREIAD LMQLDDDAKR QSTALAANQA LFDGSRVVAD EVVRARIAAL ADADYVRRPE 

       430        440        450        460        470        480 
RGERQRLQRE ALGLPLLPTT TIGSFPQTKQ VRAERARLRK GEISQGQYDE FIRRQIDDVV 

       490        500        510        520        530        540 
AKQEQIGLDV LVHGEFERND MVEYFGQNLN GFLFTKNAWV QSYGTRCVKP PIIWGDVSRA 

       550        560        570        580        590        600 
QPITVAWSSY AQSRTAKPMK GMLTGPVTIL NWSWPREDIT HEEQTKQLAL AIRDEVLDLE 

       610        620        630        640        650        660 
KAGIRIIQID EAALREKLPL RESDWHREYL DWAIPAFRLV HSAVQPSTQI HTHMCYSEFN 

       670        680        690        700        710        720 
DIISDIDAMD ADVISFEASR GDLVVLDAIH DAHFETEAGP GVYDIHSPRI PSVEETEERI 

       730        740        750        760 
GEILAKMDVN KVWINPDCGL KTRGNDETWP SLTHMVQAAK AMRANLD

« Hide

References

[1]"Comparison of the complete genome sequences of Bifidobacterium animalis subsp. lactis DSM 10140 and Bl-04."
Barrangou R., Briczinski E.P., Traeger L.L., Loquasto J.R., Richards M., Horvath P., Coute-Monvoisin A.-C., Leyer G., Rendulic S., Steele J.L., Broadbent J.R., Oberg T., Dudley E.G., Schuster S., Romero D.A., Roberts R.F.
J. Bacteriol. 191:4144-4151(2009) [PubMed: 19376856] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP001515 Genomic DNA. Translation: ACS46246.1.
RefSeqYP_002968308.1. NC_012814.1.

3D structure databases

ProteinModelPortalC6A7Z8.
ModBaseSearch...

Protein-protein interaction databases

STRINGC6A7Z8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID8008839.
GenomeReviewsGene locus Balac_0884 in contig CP001515_GR.
KEGGblc:Balac_0884.
PATRIC21107993. VBIBifAni84420_0883.

Organism-specific databases

CMRSearch...

Phylogenomic databases

OMARNIWRAN.
ProtClustDBPRK05222.

Family and domain databases

HAMAPMF_00172. Meth_synth.
[Tree]
InterProIPR013215. Cbl-indep_Met_Synth_N.
IPR006276. Cobalamin-indep_Met_synthase.
IPR002629. Methionine_synth.
[Graphical view]
KOK00549.
PfamPF08267. Meth_synt_1. 1 hit.
PF01717. Meth_synt_2. 1 hit.
[Graphical view]
PIRSFPIRSF000382. MeTrfase_B12_ind. 1 hit.
TIGRFAMsTIGR01371. Met_syn_B12ind. 1 hit.
ProtoNetSearch...

Entry information

Entry nameC6A7Z8_BIFLB
AccessionPrimary (citable) accession number: C6A7Z8
Entry history
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: December 14, 2011
This is version 17 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info