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Protein

Alanine racemase

Gene

Balac_0584

Organism
Bifidobacterium animalis subsp. lactis (strain Bl-04 / DGCC2908 / RB 4825 / SD5219)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotationSAAS annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei66 – 661Proton acceptor; specific for D-alanineUniRule annotation
Binding sitei168 – 1681SubstrateUniRule annotation
Active sitei306 – 3061Proton acceptor; specific for L-alanineUniRule annotation
Binding sitei370 – 3701Substrate; via amide nitrogenUniRule annotation

GO - Molecular functioni

  1. alanine racemase activity Source: UniProtKB-HAMAP
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

IsomeraseUniRule annotationSAAS annotation

Keywords - Ligandi

Pyridoxal phosphateUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciBANI580050:GI23-584-MONOMER.
UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemaseUniRule annotation (EC:5.1.1.1UniRule annotation)
Gene namesi
Ordered Locus Names:Balac_0584Imported
OrganismiBifidobacterium animalis subsp. lactis (strain Bl-04 / DGCC2908 / RB 4825 / SD5219)Imported
Taxonomic identifieri580050 [NCBI]
Taxonomic lineageiBacteriaActinobacteriaActinobacteridaeBifidobacterialesBifidobacteriaceaeBifidobacterium
ProteomesiUP000002343 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei66 – 661N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Protein-protein interaction databases

STRINGi580050.Balac_0584.

Structurei

3D structure databases

ProteinModelPortaliC6A761.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6A761-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVCMSVSALE EWQFSSEQGE RNYNQALREY PAQVIVDLAA LRDNMRHLVD
60 70 80 90 100
ITNREGGPTE VMGVVKADAY GHGLVPSALA ALAGGATWLG VAQAREALAL
110 120 130 140 150
RNAGIGVDRA RVLTWVNNPL HAPYDDLIAA DVDLSVATLT AIQKIAEAAR
160 170 180 190 200
AVGKPARVHI KVDTGFGRNG FTLAQIDSAI DLLLPLVDEG VFEIVGQWSH
210 220 230 240 250
LAVADAPAVG EFVEKTDEQI RVFEEFTSRL HARGIEPRIR HLANTAATLS
260 270 280 290 300
RPEIHYDLVR PGVALYGYEA DPAMGTPSKY ELRPAMTLQA QLSSVKNVGA
310 320 330 340 350
GEGLSYGRVY VTDEPTSAAI VPVGYADGIH RSASGFNEAG SKHVNKPGAP
360 370 380 390 400
VRVMTRDGAR IFHVSGRVCM DQFILDLHGD AENMGVHIGD TVELFGPGRG
410 420 430 440 450
EDYLEPTADD WARAADTISY EIFTCLRNRV PRLYANAFEV LDETDLGKLD

QSTLL
Length:455
Mass (Da):49,253
Last modified:September 1, 2009 - v1
Checksum:i7C040E0385AB7865
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001515 Genomic DNA. Translation: ACS45959.1.
RefSeqiYP_002968021.1. NC_012814.1.

Genome annotation databases

EnsemblBacteriaiACS45959; ACS45959; Balac_0584.
KEGGiblc:Balac_0584.
PATRICi21107387. VBIBifAni84420_0593.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001515 Genomic DNA. Translation: ACS45959.1.
RefSeqiYP_002968021.1. NC_012814.1.

3D structure databases

ProteinModelPortaliC6A761.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi580050.Balac_0584.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS45959; ACS45959; Balac_0584.
KEGGiblc:Balac_0584.
PATRICi21107387. VBIBifAni84420_0593.

Phylogenomic databases

eggNOGiCOG0787.
HOGENOMiHOG000031444.
KOiK01775.
OMAiPSDWVRP.
OrthoDBiEOG6PP9NJ.

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.
BioCyciBANI580050:GI23-584-MONOMER.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Bl-04 / DGCC2908 / RB 4825 / SD5219Imported.

Entry informationi

Entry nameiC6A761_BIFLB
AccessioniPrimary (citable) accession number: C6A761
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: April 29, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.