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Protein

NAD kinase

Gene

nadK

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.UniRule annotation

Catalytic activityi

ATP + NAD+ = ADP + NADP+.UniRule annotation

Cofactori

a divalent metal cationUniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei67Proton acceptorUniRule annotation1
Binding sitei72NADUniRule annotation1
Binding sitei147NADUniRule annotation1
Binding sitei164NADUniRule annotation1
Binding sitei166NADUniRule annotation1
Binding sitei201NAD; via carbonyl oxygenUniRule annotation1
Binding sitei235NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi67 – 68NADUniRule annotation2
Nucleotide bindingi136 – 137NADUniRule annotation2
Nucleotide bindingi177 – 182NADUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, NAD, NADP, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
NAD kinaseUniRule annotation (EC:2.7.1.23UniRule annotation)
Alternative name(s):
ATP-dependent NAD kinaseUniRule annotation
Gene namesi
Name:nadKUniRule annotation
Ordered Locus Names:TSIB_1840
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009079 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002054331 – 276NAD kinaseAdd BLAST276

Interactioni

Protein-protein interaction databases

STRINGi604354.TSIB_1840.

Family & Domainsi

Sequence similaritiesi

Belongs to the NAD kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01348. Archaea.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiCAMNEAV.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6A5J6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKFGIVARRD REEALKLAYR VYDFLKVNNY EVYVDEEAYI HFPHFSSEDV
60 70 80 90 100
LSLKKMDVDM IIAIGGDGTV LRVEHNTSKD IPILAVNMGT LGFLAEIEPA
110 120 130 140 150
ETFFAISRIL EGDYFIDERM KIRVFVEDVS IPDALNDVVI LTSIPGKVTH
160 170 180 190 200
LKYYVDGELA EDIRADGLII STPTGSTAYA LSAGGPLVDP RLHAILLVPL
210 220 230 240 250
APVALTARPL VVPDCSSIEI EVLTEREIVL TVDGQFYTQL PSNLKIRVEK
260 270
SPRKTKFVRF SERIYPKYTL KIKKKF
Length:276
Mass (Da):31,082
Last modified:September 1, 2009 - v1
Checksum:i7F5E3024AA794080
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS90891.1.
RefSeqiWP_015850107.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS90891; ACS90891; TSIB_1840.
GeneIDi8096851.
KEGGitsi:TSIB_1840.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS90891.1.
RefSeqiWP_015850107.1. NC_012883.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi604354.TSIB_1840.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS90891; ACS90891; TSIB_1840.
GeneIDi8096851.
KEGGitsi:TSIB_1840.

Phylogenomic databases

eggNOGiarCOG01348. Archaea.
COG0061. LUCA.
HOGENOMiHOG000227222.
KOiK00858.
OMAiCAMNEAV.

Family and domain databases

Gene3Di2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPiMF_00361. NAD_kinase. 1 hit.
InterProiIPR017438. ATP-NAD_kinase_dom_1.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. NADK.
[Graphical view]
PANTHERiPTHR20275. PTHR20275. 1 hit.
PfamiPF01513. NAD_kinase. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiNADK_THESM
AccessioniPrimary (citable) accession number: C6A5J6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: November 30, 2016
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.