Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Thymidine kinase

Gene

tdk

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + thymidine = ADP + thymidine 5'-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei95Proton acceptorUniRule annotation1
Metal bindingi151ZincUniRule annotation1
Metal bindingi154ZincUniRule annotation1
Metal bindingi189ZincUniRule annotation1
Metal bindingi192ZincUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi16 – 23ATPUniRule annotation8
Nucleotide bindingi94 – 97ATPUniRule annotation4

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotationImported, Transferase

Keywords - Biological processi

DNA synthesisUniRule annotation

Keywords - Ligandi

ATP-bindingUniRule annotation, Metal-bindingUniRule annotation, Nucleotide-binding, ZincUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine kinaseUniRule annotation (EC:2.7.1.21UniRule annotation)
Gene namesi
Name:tdkUniRule annotation
Ordered Locus Names:TSIB_1597Imported
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)Imported
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009079 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi604354.TSIB_1597.

Structurei

3D structure databases

ProteinModelPortaliC6A4V3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine kinase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04798. Archaea.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiFKGKPFG.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6A4V3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKFMHPEGF LEVITGPMFA GKTSELIKRI ERQIFAKRKA ALFKPSIDNR
60 70 80 90 100
YSEDKLVAHN GLSYEAFVIP TTEEGVKMIY QKTKKEGFEV IGIDEVQFFP
110 120 130 140 150
MSIVEILDKL ADEGIYVIAS GLNLDFKGDA FEVTKELLAM ADNIVYLTAI
160 170 180 190
CSVCGREATR TQRLINGKPA PRDSPRILVG GMEAYEARCR KHHIVP
Length:196
Mass (Da):22,030
Last modified:September 1, 2009 - v1
Checksum:i92C8F9910DAC96C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS90648.1.

Genome annotation databases

EnsemblBacteriaiACS90648; ACS90648; TSIB_1597.
KEGGitsi:TSIB_1597.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS90648.1.

3D structure databases

ProteinModelPortaliC6A4V3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi604354.TSIB_1597.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS90648; ACS90648; TSIB_1597.
KEGGitsi:TSIB_1597.

Phylogenomic databases

eggNOGiarCOG04798. Archaea.
COG1435. LUCA.
HOGENOMiHOG000076390.
KOiK00857.
OMAiFKGKPFG.

Family and domain databases

HAMAPiMF_00124. Thymidine_kinase. 1 hit.
InterProiIPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
[Graphical view]
PANTHERiPTHR11441. PTHR11441. 1 hit.
PfamiPF00265. TK. 1 hit.
[Graphical view]
PIRSFiPIRSF035805. TK_cell. 1 hit.
PROSITEiPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiC6A4V3_THESM
AccessioniPrimary (citable) accession number: C6A4V3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: November 30, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.