C6A4I1 (C6A4I1_THESM) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
5'-nucleotidase surE HAMAP MF_00060
EC=3.1.3.5 HAMAP MF_00060

Alternative name(s):
Nucleoside 5'-monophosphate phosphohydrolase HAMAP MF_00060

Gene names

Name:	surE HAMAP MF_00060
Ordered Locus Names:	TSIB_1475

Organism

Thermococcus sibiricus (strain MM 739 / DSM 12597) [Complete proteome] [HAMAP]

Taxonomic identifier

604354 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates By similarity. HAMAP MF_00060
Catalytic activity	A 5'-ribonucleotide + H2O = a ribonucleoside + phosphate. HAMAP MF_00060
Cofactor	Binds 1 divalent metal cation per subunit By similarity. HAMAP MF_00060
Subcellular location	Cytoplasm By similarity HAMAP MF_00060.
Sequence similarities	Belongs to the surE nucleotidase family. HAMAP MF_00060

Ontologies

Keywords
Cellular component	Cytoplasm HAMAP MF_00060
Ligand	Metal-binding HAMAP MF_00060 Nucleotide-binding HAMAP MF_00060
Molecular function	Hydrolase HAMAP MF_00060 EMBL ACS90526.1
Technical term	Complete proteome
Gene Ontology (GO)
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	5'-nucleotidase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: HAMAP nucleotide binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Metal binding	9	1	Divalent metal cation By similarity HAMAP MF_00060
	Metal binding	10	1	Divalent metal cation By similarity HAMAP MF_00060
	Metal binding	40	1	Divalent metal cation By similarity HAMAP MF_00060
	Metal binding	94	1	Divalent metal cation By similarity HAMAP MF_00060

Sequences

	Sequence		Length	Mass (Da)
	C6A4I1 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: F695A2447D083045	FASTA	261	28,798
	10 20 30 40 50 60 MAKILVTNDD GIHSRGIKAA VEALQDLGEV YVVAPMFQRS ASGRAMTLHR PLRVKRINLK 70 80 90 100 110 120 GTKVAYALDG MPVDCVIFAM ARFGKFDLAV SGINLGENMS TEITISGTAS AAIEAATHDI 130 140 150 160 170 180 PSIAMSLEVN REKHKFGEGE EIDFSVAKSF LKRISNAILS NGMPKSVDML NINVPYDAHE 190 200 210 220 230 240 NTPIELTKLA KRMYMASVEE RVDPKGNPYY WIVGTQCPKD TLEPGTDMYA LKVERKVSVT 250 260 PINLNMTAKV NFNDVRRHLQ L

References

[1]

"Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis." Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G. Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed: 19447963] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001463 Genomic DNA. Translation: ACS90526.1.
RefSeq	YP_002994875.1. NC_012883.1.
3D structure databases
ProteinModelPortal	C6A4I1.
ModBase	Search...
Protein-protein interaction databases
STRING	C6A4I1.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	8096480.
GenomeReviews	Gene locus TSIB_1475 in contig CP001463_GR.
KEGG	tsi:TSIB_1475.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	NGFYYVN.
ProtClustDB	PRK00346.
Family and domain databases
HAMAP	MF_00060. SurE. [Tree]
InterPro	IPR002828. SurE-like_Pase/nucleotidase. [Graphical view]
Gene3D	G3DSA:3.40.1210.10. SurE-like_Pase/nucleotidase. 1 hit.
KO	K03787.
Pfam	PF01975. SurE. 1 hit. [Graphical view]
SUPFAM	SSF64167. SurE-like_Pase/nucleotidase. 1 hit.
TIGRFAMs	TIGR00087. SurE. 1 hit.
ProtoNet	Search...

Entry information

Entry name

C6A4I1_THESM

Accession

Primary (citable) accession number: C6A4I1

Entry history

Integrated into UniProtKB/TrEMBL:	September 1, 2009
Last sequence update:	September 1, 2009
Last modified:	November 16, 2011
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)