Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

C6A4A4

- RNP4_THESM

UniProt

C6A4A4 - RNP4_THESM

Protein

Ribonuclease P protein component 4

Gene

rnp4

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
  1. Functioni

    Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.UniRule annotation

    Catalytic activityi

    Endonucleolytic cleavage of RNA, removing 5'-extranucleotides from tRNA precursor.UniRule annotation

    Cofactori

    Binds 1 zinc ion per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi67 – 671ZincUniRule annotation
    Metal bindingi70 – 701ZincUniRule annotation
    Metal bindingi96 – 961ZincUniRule annotation
    Metal bindingi99 – 991ZincUniRule annotation

    GO - Molecular functioni

    1. ribonuclease P activity Source: UniProtKB-HAMAP
    2. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tRNA 5'-leader removal Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Endonuclease, Hydrolase, Nuclease

    Keywords - Biological processi

    tRNA processing

    Keywords - Ligandi

    Metal-binding, Zinc

    Enzyme and pathway databases

    BioCyciTSIB604354:GHMS-1433-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribonuclease P protein component 4UniRule annotation (EC:3.1.26.5UniRule annotation)
    Short name:
    RNase P component 4UniRule annotation
    Alternative name(s):
    Rpp21UniRule annotation
    Gene namesi
    Name:rnp4UniRule annotation
    Ordered Locus Names:TSIB_1398
    OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
    Taxonomic identifieri604354 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000009079: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. ribonuclease P complex Source: UniProtKB-HAMAP

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 120120Ribonuclease P protein component 4PRO_1000212868Add
    BLAST

    Interactioni

    Subunit structurei

    Consists of a catalytic RNA component and at least 4-5 protein subunits.UniRule annotation

    Protein-protein interaction databases

    STRINGi604354.TSIB_1398.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the eukaryotic/archaeal RNase P protein component 4 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2023.
    HOGENOMiHOG000230709.
    KOiK03540.
    OMAiPRKWKRR.

    Family and domain databases

    HAMAPiMF_00757. RNase_P_4.
    InterProiIPR016432. RNase_P_comp-4.
    IPR007175. Rpr2.
    [Graphical view]
    PANTHERiPTHR14742. PTHR14742. 1 hit.
    PfamiPF04032. Rpr2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF004878. RNase_P_4. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6A4A4-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSKKFSRRKE QREKKKIALE RIDILFNLAE RVFAYDKELA NRYVEIALAV    50
    QQKAKVRMPR KWKRRYCKKC HSFLVPGVNA RVRLRQKRMP HVVIKCLECG 100
    HIMRYPYLRE KKERRKAKKQ 120
    Length:120
    Mass (Da):14,701
    Last modified:September 1, 2009 - v1
    Checksum:iBE48E990B3417135
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001463 Genomic DNA. Translation: ACS90449.1.
    RefSeqiYP_002994798.1. NC_012883.1.

    Genome annotation databases

    EnsemblBacteriaiACS90449; ACS90449; TSIB_1398.
    GeneIDi8096400.
    KEGGitsi:TSIB_1398.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001463 Genomic DNA. Translation: ACS90449.1 .
    RefSeqi YP_002994798.1. NC_012883.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 604354.TSIB_1398.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS90449 ; ACS90449 ; TSIB_1398 .
    GeneIDi 8096400.
    KEGGi tsi:TSIB_1398.

    Phylogenomic databases

    eggNOGi COG2023.
    HOGENOMi HOG000230709.
    KOi K03540.
    OMAi PRKWKRR.

    Enzyme and pathway databases

    BioCyci TSIB604354:GHMS-1433-MONOMER.

    Family and domain databases

    HAMAPi MF_00757. RNase_P_4.
    InterProi IPR016432. RNase_P_comp-4.
    IPR007175. Rpr2.
    [Graphical view ]
    PANTHERi PTHR14742. PTHR14742. 1 hit.
    Pfami PF04032. Rpr2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF004878. RNase_P_4. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
      Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
      Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MM 739 / DSM 12597.

    Entry informationi

    Entry nameiRNP4_THESM
    AccessioniPrimary (citable) accession number: C6A4A4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 30 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3