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C6A2T7

- C6A2T7_THESM

UniProt

C6A2T7 - C6A2T7_THESM

Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

    Catalytic activityi

    Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    GO - Molecular functioni

    1. magnesium ion binding Source: UniProtKB-HAMAP
    2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. carbon fixation Source: UniProtKB-HAMAP
    2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
    3. tricarboxylic acid cycle Source: InterPro

    Keywords - Molecular functioni

    LyaseUniRule annotationImported

    Keywords - Biological processi

    Carbon dioxide fixationUniRule annotation

    Keywords - Ligandi

    MagnesiumUniRule annotation, PyruvateImported

    Enzyme and pathway databases

    BioCyciTSIB604354:GHMS-896-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
    Short name:
    PEPCUniRule annotation
    Short name:
    PEPCaseUniRule annotation
    Gene namesi
    Name:ppcAUniRule annotation
    Ordered Locus Names:TSIB_0872Imported
    OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)Imported
    Taxonomic identifieri604354 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000009079: Chromosome

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi604354.TSIB_0872.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PEPCase type 2 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1892.
    HOGENOMiHOG000038601.
    KOiK01595.
    OMAiDEYMPDY.

    Family and domain databases

    HAMAPiMF_01904. PEPcase_type2.
    InterProiIPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view]
    PfamiPF14010. PEPcase_2. 1 hit.
    [Graphical view]
    PIRSFiPIRSF006677. UCP006677. 1 hit.
    SUPFAMiSSF51621. SSF51621. 1 hit.
    TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    C6A2T7-1 [UniParc]FASTAAdd to Basket

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    MIFVSLVDYM IPRTMSTQHP DNVYIPFFAH ESSLGGEDEV LEAFYAFSVL    50
    GVQEQMWDFE GKEVDEFVIK KLLEKYGQFF KKKKLGRDIR ITPRVPNPSV 100
    EKAEAKLLLE TLESIPRSAD YAKLFYGEEI APIFEVILPM TTSSKEIERV 150
    YELYKRYIIG KQYKRVYDIK IYEWIGEFYP EEINVIPLFE TKEAILNSHE 200
    ILKEYLTGKN FEYQRVFLAR SDPAMNYGLI SAVIYDKYAL FNIQELEEEL 250
    SVPIYPIIGV GSAPFRGHFI PENVENTIKE YPNVQTFTVQ SSFKYDNDPK 300
    EVIRAIEKVN ERKRKKSASV DEGVFKILEK YEKEYTAELK LLAPYIREIA 350
    KFVPSRRKRK LHIGLFGYSR KINGEVLPRA IKFTASLYSL GVPPELLGLS 400
    TLSEKDIEEL AEYYYGLYRD LEFALKFFNP KTSQKFKFLN KIVKLQKEMG 450
    IEAEERHQTL TSQIISGKFE ESVIVQAADI RGFLG 485
    Length:485
    Mass (Da):56,423
    Last modified:September 1, 2009 - v1
    Checksum:iFA5093DA6098E8AF
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001463 Genomic DNA. Translation: ACS89932.1.
    RefSeqiWP_015849152.1. NC_012883.1.
    YP_002994281.1. NC_012883.1.

    Genome annotation databases

    EnsemblBacteriaiACS89932; ACS89932; TSIB_0872.
    GeneIDi8095863.
    KEGGitsi:TSIB_0872.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001463 Genomic DNA. Translation: ACS89932.1 .
    RefSeqi WP_015849152.1. NC_012883.1.
    YP_002994281.1. NC_012883.1.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 604354.TSIB_0872.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS89932 ; ACS89932 ; TSIB_0872 .
    GeneIDi 8095863.
    KEGGi tsi:TSIB_0872.

    Phylogenomic databases

    eggNOGi COG1892.
    HOGENOMi HOG000038601.
    KOi K01595.
    OMAi DEYMPDY.

    Enzyme and pathway databases

    BioCyci TSIB604354:GHMS-896-MONOMER.

    Family and domain databases

    HAMAPi MF_01904. PEPcase_type2.
    InterProi IPR007566. PEP_COase_arc-type.
    IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
    [Graphical view ]
    Pfami PF14010. PEPcase_2. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF006677. UCP006677. 1 hit.
    SUPFAMi SSF51621. SSF51621. 1 hit.
    TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
      Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
      Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MM 739 / DSM 12597Imported.

    Entry informationi

    Entry nameiC6A2T7_THESM
    AccessioniPrimary (citable) accession number: C6A2T7
    Entry historyi
    Integrated into UniProtKB/TrEMBL: September 1, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3