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C6A2T7

- C6A2T7_THESM

UniProt

C6A2T7 - C6A2T7_THESM

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Protein

Phosphoenolpyruvate carboxylase

Gene

ppcA

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationImported

Keywords - Biological processi

Carbon dioxide fixationUniRule annotation

Keywords - Ligandi

MagnesiumUniRule annotation, PyruvateImported

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-896-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotation (EC:4.1.1.31UniRule annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcAUniRule annotation
Ordered Locus Names:TSIB_0872Imported
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)Imported
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009079: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi604354.TSIB_0872.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000038601.
KOiK01595.
OMAiDEYMPDY.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

C6A2T7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MIFVSLVDYM IPRTMSTQHP DNVYIPFFAH ESSLGGEDEV LEAFYAFSVL
60 70 80 90 100
GVQEQMWDFE GKEVDEFVIK KLLEKYGQFF KKKKLGRDIR ITPRVPNPSV
110 120 130 140 150
EKAEAKLLLE TLESIPRSAD YAKLFYGEEI APIFEVILPM TTSSKEIERV
160 170 180 190 200
YELYKRYIIG KQYKRVYDIK IYEWIGEFYP EEINVIPLFE TKEAILNSHE
210 220 230 240 250
ILKEYLTGKN FEYQRVFLAR SDPAMNYGLI SAVIYDKYAL FNIQELEEEL
260 270 280 290 300
SVPIYPIIGV GSAPFRGHFI PENVENTIKE YPNVQTFTVQ SSFKYDNDPK
310 320 330 340 350
EVIRAIEKVN ERKRKKSASV DEGVFKILEK YEKEYTAELK LLAPYIREIA
360 370 380 390 400
KFVPSRRKRK LHIGLFGYSR KINGEVLPRA IKFTASLYSL GVPPELLGLS
410 420 430 440 450
TLSEKDIEEL AEYYYGLYRD LEFALKFFNP KTSQKFKFLN KIVKLQKEMG
460 470 480
IEAEERHQTL TSQIISGKFE ESVIVQAADI RGFLG
Length:485
Mass (Da):56,423
Last modified:September 1, 2009 - v1
Checksum:iFA5093DA6098E8AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS89932.1.
RefSeqiWP_015849152.1. NC_012883.1.
YP_002994281.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS89932; ACS89932; TSIB_0872.
GeneIDi8095863.
KEGGitsi:TSIB_0872.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS89932.1 .
RefSeqi WP_015849152.1. NC_012883.1.
YP_002994281.1. NC_012883.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 604354.TSIB_0872.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS89932 ; ACS89932 ; TSIB_0872 .
GeneIDi 8095863.
KEGGi tsi:TSIB_0872.

Phylogenomic databases

eggNOGi COG1892.
HOGENOMi HOG000038601.
KOi K01595.
OMAi DEYMPDY.

Enzyme and pathway databases

BioCyci TSIB604354:GHMS-896-MONOMER.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
    Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
    Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MM 739 / DSM 12597Imported.

Entry informationi

Entry nameiC6A2T7_THESM
AccessioniPrimary (citable) accession number: C6A2T7
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: October 1, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3