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C6A2R5

- PDAD_THESM

UniProt

C6A2R5 - PDAD_THESM

Protein

Pyruvoyl-dependent arginine decarboxylase

Gene

pdaD

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 33 (01 Oct 2014)
      Sequence version 1 (01 Sep 2009)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    L-arginine = agmatine + CO2.UniRule annotation

    Cofactori

    Pyruvoyl group.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei43 – 442Cleavage (non-hydrolytic)UniRule annotation

    GO - Molecular functioni

    1. arginine decarboxylase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. arginine catabolic process Source: InterPro

    Keywords - Molecular functioni

    Decarboxylase, Lyase

    Keywords - Ligandi

    Pyruvate

    Enzyme and pathway databases

    BioCyciTSIB604354:GHMS-873-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Pyruvoyl-dependent arginine decarboxylaseUniRule annotation (EC:4.1.1.19UniRule annotation)
    Short name:
    PvlArgDCUniRule annotation
    Cleaved into the following 2 chains:
    Pyruvoyl-dependent arginine decarboxylase subunit betaUniRule annotation
    Pyruvoyl-dependent arginine decarboxylase subunit alphaUniRule annotation
    Gene namesi
    Name:pdaDUniRule annotation
    Ordered Locus Names:TSIB_0849
    OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
    Taxonomic identifieri604354 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
    ProteomesiUP000009079: Chromosome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 4343Pyruvoyl-dependent arginine decarboxylase subunit betaUniRule annotationPRO_1000215198Add
    BLAST
    Chaini44 – 158115Pyruvoyl-dependent arginine decarboxylase subunit alphaUniRule annotationPRO_1000215199Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei44 – 441Pyruvic acid (Ser)UniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi604354.TSIB_0849.

    Structurei

    3D structure databases

    ProteinModelPortaliC6A2R5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the PdaD family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1945.
    HOGENOMiHOG000012204.
    KOiK02626.
    OMAiISSIMPP.

    Family and domain databases

    Gene3Di3.50.20.10. 1 hit.
    HAMAPiMF_01404. PvlArgDC.
    InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view]
    PfamiPF01862. PvlArgDC. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view] [Entries sharing at least one domain]
    SUPFAMiSSF56271. SSF56271. 1 hit.
    TIGRFAMsiTIGR00286. TIGR00286. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    C6A2R5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSWTTPKKAI LLAASAEGST KLNAFDNALL KMGIGNVNLV KLSSVIPAYI    50
    EWIDELPKNI PVGMLLPTVY AHIESDEPGS TITAALGVGI SEGNEGGLIY 100
    EYSGYCTKEE AEKMVHKMVE EGFKVRGWKL KEFKAAVAEI TVKDRPVAAI 150
    AAVVMLPY 158
    Length:158
    Mass (Da):17,071
    Last modified:September 1, 2009 - v1
    Checksum:i97831E53ABC8F769
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001463 Genomic DNA. Translation: ACS89910.1.
    RefSeqiWP_015849130.1. NC_012883.1.
    YP_002994259.1. NC_012883.1.

    Genome annotation databases

    EnsemblBacteriaiACS89910; ACS89910; TSIB_0849.
    GeneIDi8095840.
    KEGGitsi:TSIB_0849.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP001463 Genomic DNA. Translation: ACS89910.1 .
    RefSeqi WP_015849130.1. NC_012883.1.
    YP_002994259.1. NC_012883.1.

    3D structure databases

    ProteinModelPortali C6A2R5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 604354.TSIB_0849.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ACS89910 ; ACS89910 ; TSIB_0849 .
    GeneIDi 8095840.
    KEGGi tsi:TSIB_0849.

    Phylogenomic databases

    eggNOGi COG1945.
    HOGENOMi HOG000012204.
    KOi K02626.
    OMAi ISSIMPP.

    Enzyme and pathway databases

    BioCyci TSIB604354:GHMS-873-MONOMER.

    Family and domain databases

    Gene3Di 3.50.20.10. 1 hit.
    HAMAPi MF_01404. PvlArgDC.
    InterProi IPR016104. Pyr-dep_his/arg-deCO2ase.
    IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
    IPR002724. Pyruvoyl-dep_arg_deCO2ase.
    [Graphical view ]
    Pfami PF01862. PvlArgDC. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    ProDomi PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    SUPFAMi SSF56271. SSF56271. 1 hit.
    TIGRFAMsi TIGR00286. TIGR00286. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
      Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
      Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MM 739 / DSM 12597.

    Entry informationi

    Entry nameiPDAD_THESM
    AccessioniPrimary (citable) accession number: C6A2R5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 22, 2009
    Last sequence update: September 1, 2009
    Last modified: October 1, 2014
    This is version 33 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3