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C6A2R5

- PDAD_THESM

UniProt

C6A2R5 - PDAD_THESM

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Protein

Pyruvoyl-dependent arginine decarboxylase

Gene
pdaD, TSIB_0849
Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Pyruvoyl group By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei43 – 442Cleavage (non-hydrolytic) By similarity

GO - Molecular functioni

  1. arginine decarboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Ligandi

Pyruvate

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-873-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Pyruvoyl-dependent arginine decarboxylase (EC:4.1.1.19)
Short name:
PvlArgDC
Cleaved into the following 2 chains:
Gene namesi
Name:pdaD
Ordered Locus Names:TSIB_0849
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009079: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 4343Pyruvoyl-dependent arginine decarboxylase subunit beta By similarityPRO_1000215198Add
BLAST
Chaini44 – 158115Pyruvoyl-dependent arginine decarboxylase subunit alpha By similarityPRO_1000215199Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei44 – 441Pyruvic acid (Ser) By similarity

Interactioni

Protein-protein interaction databases

STRINGi604354.TSIB_0849.

Structurei

3D structure databases

ProteinModelPortaliC6A2R5.

Family & Domainsi

Sequence similaritiesi

Belongs to the PdaD family.

Phylogenomic databases

eggNOGiCOG1945.
HOGENOMiHOG000012204.
KOiK02626.
OMAiISSIMPP.

Family and domain databases

Gene3Di3.50.20.10. 1 hit.
HAMAPiMF_01404. PvlArgDC.
InterProiIPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
[Graphical view]
PfamiPF01862. PvlArgDC. 1 hit.
[Graphical view]
PIRSFiPIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomiPD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF56271. SSF56271. 1 hit.
TIGRFAMsiTIGR00286. TIGR00286. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

C6A2R5-1 [UniParc]FASTAAdd to Basket

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MSWTTPKKAI LLAASAEGST KLNAFDNALL KMGIGNVNLV KLSSVIPAYI    50
EWIDELPKNI PVGMLLPTVY AHIESDEPGS TITAALGVGI SEGNEGGLIY 100
EYSGYCTKEE AEKMVHKMVE EGFKVRGWKL KEFKAAVAEI TVKDRPVAAI 150
AAVVMLPY 158
Length:158
Mass (Da):17,071
Last modified:September 1, 2009 - v1
Checksum:i97831E53ABC8F769
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS89910.1.
RefSeqiWP_015849130.1. NC_012883.1.
YP_002994259.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS89910; ACS89910; TSIB_0849.
GeneIDi8095840.
KEGGitsi:TSIB_0849.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS89910.1 .
RefSeqi WP_015849130.1. NC_012883.1.
YP_002994259.1. NC_012883.1.

3D structure databases

ProteinModelPortali C6A2R5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 604354.TSIB_0849.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS89910 ; ACS89910 ; TSIB_0849 .
GeneIDi 8095840.
KEGGi tsi:TSIB_0849.

Phylogenomic databases

eggNOGi COG1945.
HOGENOMi HOG000012204.
KOi K02626.
OMAi ISSIMPP.

Enzyme and pathway databases

BioCyci TSIB604354:GHMS-873-MONOMER.

Family and domain databases

Gene3Di 3.50.20.10. 1 hit.
HAMAPi MF_01404. PvlArgDC.
InterProi IPR016104. Pyr-dep_his/arg-deCO2ase.
IPR016105. Pyr-dep_his/arg-deCO2ase_sand.
IPR002724. Pyruvoyl-dep_arg_deCO2ase.
[Graphical view ]
Pfami PF01862. PvlArgDC. 1 hit.
[Graphical view ]
PIRSFi PIRSF005216. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
ProDomi PD010449. Pyruvoyl-dep_arg_deCO2ase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF56271. SSF56271. 1 hit.
TIGRFAMsi TIGR00286. TIGR00286. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
    Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
    Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MM 739 / DSM 12597.

Entry informationi

Entry nameiPDAD_THESM
AccessioniPrimary (citable) accession number: C6A2R5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: September 3, 2014
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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