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C6A2A0

- AMPPA_THESM

UniProt

C6A2A0 - AMPPA_THESM

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Protein

AMP phosphorylase

Gene

TSIB_0680

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei168 – 1681AMP; via amide nitrogenUniRule annotation
Binding sitei203 – 2031AMP; via amide nitrogenUniRule annotation
Active sitei256 – 2561Proton donorUniRule annotation
Binding sitei264 – 2641AMPUniRule annotation
Binding sitei288 – 2881AMPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi194 – 1996AMPUniRule annotation

GO - Molecular functioni

  1. AMP binding Source: UniProtKB-HAMAP
  2. phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: InterPro

GO - Biological processi

  1. AMP catabolic process Source: UniProtKB-HAMAP
  2. pyrimidine deoxyribonucleoside metabolic process Source: InterPro
  3. pyrimidine nucleobase metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-701-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:TSIB_0680
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009079: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 503503AMP phosphorylasePRO_1000212644Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi604354.TSIB_0680.

Structurei

3D structure databases

ProteinModelPortaliC6A2A0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
HOGENOMiHOG000252767.
KOiK00758.
OMAiFINGVRD.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_02132. AMP_phosphorylase.
InterProiIPR017713. AMP_phosphorylase.
IPR009010. Asp_de-COase-like_dom.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF50692. SSF50692. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6A2A0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MKAKVRILDI ETGRFLAFIS EEDAKNAKLH PGDLVKIETA KRTIYGDVVI
60 70 80 90 100
SKTINPGEIG VTKDILRSYT FSEGEVVNLV PSETPESVRY IRRKMNGQKL
110 120 130 140 150
KKVEIEAIVK DIVNRKLRDI EISSFVTSLE INGLDMDEIA WLTTAMAETG
160 170 180 190 200
DMLDIDRKPI MDVHSIGGVP GNKTNILVVP IVAAAGLTIP KTSSRAITSA
210 220 230 240 250
AGTADVVEVL APVTHSLDEI KRIVEKIGAC LVWGGALNLA PADDLTIKAE
260 270 280 290 300
RALSIDPRGL MLASIMSKKY AMGSQYVLID IPTGEGVKVE KVEDARSLAK
310 320 330 340 350
DFIELGKRLG QYVETAITYG GQPIGHTVGP ALEAKEALET IIEGKGPGSL
360 370 380 390 400
VEKATGLAGI LLEMGGVAPA GMGKKMAKEI LESGKAYEKL KEIIEEQGGD
410 420 430 440 450
PNIKPEDIPI GDKTYTFVAQ TSGYITRIDN KAITAIARAA GAPEDKGAGI
460 470 480 490 500
MLHVKVGEKV KERDPLFTVH AESGTRLDQA IIQARRMEPI RIEGMVLQRI

GNI
Length:503
Mass (Da):54,203
Last modified:September 1, 2009 - v1
Checksum:i67806AF5CB4333F5
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS89745.1.
RefSeqiWP_015848965.1. NC_012883.1.
YP_002994094.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS89745; ACS89745; TSIB_0680.
GeneIDi8095668.
KEGGitsi:TSIB_0680.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP001463 Genomic DNA. Translation: ACS89745.1 .
RefSeqi WP_015848965.1. NC_012883.1.
YP_002994094.1. NC_012883.1.

3D structure databases

ProteinModelPortali C6A2A0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 604354.TSIB_0680.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ACS89745 ; ACS89745 ; TSIB_0680 .
GeneIDi 8095668.
KEGGi tsi:TSIB_0680.

Phylogenomic databases

eggNOGi COG0213.
HOGENOMi HOG000252767.
KOi K00758.
OMAi FINGVRD.

Enzyme and pathway databases

BioCyci TSIB604354:GHMS-701-MONOMER.

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_02132. AMP_phosphorylase.
InterProi IPR017713. AMP_phosphorylase.
IPR009010. Asp_de-COase-like_dom.
IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013466. Thymidine/AMP_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF50692. SSF50692. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR03327. AMP_phos. 1 hit.
TIGR02645. ARCH_P_rylase. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
    Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
    Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MM 739 / DSM 12597.

Entry informationi

Entry nameiAMPPA_THESM
AccessioniPrimary (citable) accession number: C6A2A0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: October 29, 2014
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3