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Protein

AMP phosphorylase

Gene

TSIB_0680

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei203AMP; via amide nitrogenUniRule annotation1
Active sitei256Proton donorUniRule annotation1
Binding sitei264AMPUniRule annotation1
Binding sitei288AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 199AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciTSIB604354:G1GV3-674-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:TSIB_0680
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009079 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_10002126441 – 503AMP phosphorylaseAdd BLAST503

Proteomic databases

PRIDEiC6A2A0

Interactioni

Protein-protein interaction databases

STRINGi604354.TSIB_0680

Structurei

3D structure databases

ProteinModelPortaliC6A2A0
SMRiC6A2A0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

C6A2A0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAKVRILDI ETGRFLAFIS EEDAKNAKLH PGDLVKIETA KRTIYGDVVI
60 70 80 90 100
SKTINPGEIG VTKDILRSYT FSEGEVVNLV PSETPESVRY IRRKMNGQKL
110 120 130 140 150
KKVEIEAIVK DIVNRKLRDI EISSFVTSLE INGLDMDEIA WLTTAMAETG
160 170 180 190 200
DMLDIDRKPI MDVHSIGGVP GNKTNILVVP IVAAAGLTIP KTSSRAITSA
210 220 230 240 250
AGTADVVEVL APVTHSLDEI KRIVEKIGAC LVWGGALNLA PADDLTIKAE
260 270 280 290 300
RALSIDPRGL MLASIMSKKY AMGSQYVLID IPTGEGVKVE KVEDARSLAK
310 320 330 340 350
DFIELGKRLG QYVETAITYG GQPIGHTVGP ALEAKEALET IIEGKGPGSL
360 370 380 390 400
VEKATGLAGI LLEMGGVAPA GMGKKMAKEI LESGKAYEKL KEIIEEQGGD
410 420 430 440 450
PNIKPEDIPI GDKTYTFVAQ TSGYITRIDN KAITAIARAA GAPEDKGAGI
460 470 480 490 500
MLHVKVGEKV KERDPLFTVH AESGTRLDQA IIQARRMEPI RIEGMVLQRI

GNI
Length:503
Mass (Da):54,203
Last modified:September 1, 2009 - v1
Checksum:i67806AF5CB4333F5
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA Translation: ACS89745.1
RefSeqiWP_015848965.1, NC_012883.1

Genome annotation databases

EnsemblBacteriaiACS89745; ACS89745; TSIB_0680
GeneIDi8095668
KEGGitsi:TSIB_0680

Similar proteinsi

Entry informationi

Entry nameiAMPPA_THESM
AccessioniPrimary (citable) accession number: C6A2A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 22, 2009
Last sequence update: September 1, 2009
Last modified: May 23, 2018
This is version 61 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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