C6A2A0 (TYPH_THESM) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Putative thymidine phosphorylase
EC=2.4.2.4

Alternative name(s):
TdRPase

Gene names

Ordered Locus Names:

TSIB_0680

Organism

Thermococcus sibiricus (strain MM 739 / DSM 12597) [Complete proteome] [HAMAP]

Taxonomic identifier

604354 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Thermococci › Thermococcales › Thermococcaceae › Thermococcus › Thermococcus sibiricus

Protein attributes

Sequence length	503 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_00703
Sequence similarities	Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.

Ontologies

Keywords
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	pyrimidine deoxyribonucleoside metabolic process Inferred from electronic annotation. Source: InterPro pyrimidine nucleobase metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	phosphorylase activity Inferred from electronic annotation. Source: InterPro thymidine phosphorylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 503	503	Putative thymidine phosphorylase HAMAP-Rule MF_00703		PRO_1000212644

Sequences

	Sequence		Length	Mass (Da)
	C6A2A0 [UniParc]. Last modified September 1, 2009. Version 1. Checksum: 67806AF5CB4333F5	FASTA	503	54,203
	10 20 30 40 50 60 MKAKVRILDI ETGRFLAFIS EEDAKNAKLH PGDLVKIETA KRTIYGDVVI SKTINPGEIG 70 80 90 100 110 120 VTKDILRSYT FSEGEVVNLV PSETPESVRY IRRKMNGQKL KKVEIEAIVK DIVNRKLRDI 130 140 150 160 170 180 EISSFVTSLE INGLDMDEIA WLTTAMAETG DMLDIDRKPI MDVHSIGGVP GNKTNILVVP 190 200 210 220 230 240 IVAAAGLTIP KTSSRAITSA AGTADVVEVL APVTHSLDEI KRIVEKIGAC LVWGGALNLA 250 260 270 280 290 300 PADDLTIKAE RALSIDPRGL MLASIMSKKY AMGSQYVLID IPTGEGVKVE KVEDARSLAK 310 320 330 340 350 360 DFIELGKRLG QYVETAITYG GQPIGHTVGP ALEAKEALET IIEGKGPGSL VEKATGLAGI 370 380 390 400 410 420 LLEMGGVAPA GMGKKMAKEI LESGKAYEKL KEIIEEQGGD PNIKPEDIPI GDKTYTFVAQ 430 440 450 460 470 480 TSGYITRIDN KAITAIARAA GAPEDKGAGI MLHVKVGEKV KERDPLFTVH AESGTRLDQA 490 500 IIQARRMEPI RIEGMVLQRI GNI

References

[1]

"Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis." Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G. Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MM 739 / DSM 12597.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP001463 Genomic DNA. Translation: ACS89745.1.
RefSeq	YP_002994094.1. NC_012883.1.
3D structure databases
ProteinModelPortal	C6A2A0.
ModBase	Search...
Protein-protein interaction databases
STRING	604354.TSIB_0680.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ACS89745; ACS89745; TSIB_0680.
GeneID	8095668.
KEGG	tsi:TSIB_0680.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0213.
HOGENOM	HOG000252767.
KO	K00758.
OMA	VHSIGGV.
ProtClustDB	PRK04350.
Family and domain databases
Gene3D	2.40.40.20. 1 hit. 3.40.1030.10. 1 hit. 3.90.1170.30. 1 hit.
HAMAP	MF_00703. Thymid_phosp_2.
InterPro	IPR017713. AMP_phosphorylase. IPR009010. Asp_de-COase-like_dom. IPR000312. Glycosyl_Trfase_fam3. IPR017459. Glycosyl_Trfase_fam3_N_dom. IPR013102. PYNP_C. IPR000053. Pyrmidine_PPase. IPR017872. Pyrmidine_PPase_CS. IPR013466. Thymidine_Pase_type2. [Graphical view]
PANTHER	PTHR10515. PTHR10515. 1 hit.
Pfam	PF02885. Glycos_trans_3N. 1 hit. PF00591. Glycos_transf_3. 1 hit. PF07831. PYNP_C. 1 hit. [Graphical view]
PIRSF	PIRSF000478. TP_PyNP. 1 hit.
SMART	SM00941. PYNP_C. 1 hit. [Graphical view]
SUPFAM	SSF47648. Glyco_trans_3. 1 hit. SSF52418. Glyco_trans_3. 1 hit. SSF54680. PYNP_C. 1 hit.
TIGRFAMs	TIGR03327. AMP_phos. 1 hit. TIGR02645. ARCH_P_rylase. 1 hit.
PROSITE	PS00647. THYMID_PHOSPHORYLASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TYPH_THESM

Accession

Primary (citable) accession number: C6A2A0

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 22, 2009
Last sequence update:	September 1, 2009
Last modified:	May 1, 2013
This is version 31 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program