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Protein

Exosome complex component Csl4

Gene

csl4

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi162 – 1621ZincUniRule annotation
Metal bindingi165 – 1651ZincUniRule annotation
Metal bindingi178 – 1781ZincUniRule annotation
Metal bindingi181 – 1811ZincUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Metal-bindingUniRule annotation, ZincUniRule annotation

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-512-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Exosome complex component Csl4UniRule annotation
Gene namesi
Name:csl4UniRule annotation
Ordered Locus Names:TSIB_0492Imported
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)Imported
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
ProteomesiUP000009079 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation, ExosomeUniRule annotation

Interactioni

Subunit structurei

Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.UniRule annotation

Protein-protein interaction databases

STRINGi604354.TSIB_0492.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini72 – 15180S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the CSL4 family.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG1096.
HOGENOMiHOG000222781.
KOiK07573.
OMAiCGNVETR.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00975. Exosome_Csl4.
InterProiIPR019495. EXOSC1.
IPR025721. Exosome_cplx_N_dom.
IPR030850. Exosome_Csl4_arc.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
[Graphical view]
PfamiPF14382. ECR1_N. 1 hit.
PF10447. EXOSC1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6A1R3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVEPKKKTVE NGELVLPGDY LGVIEEFLPG EGVIEENGEL YAARMGRVKI
60 70 80 90 100
DLEKIEISVE PVTDVPPLPQ VGDIVIARVL EVKSQAAIVE LLKIEGRKGY
110 120 130 140 150
REIATSKLAG IHVSQVKDGY VESMNSEFKI GDIVRAKVLT NNKSPIQLTT
160 170 180 190
REPDLGVIYA LCSSCKVSLV RKGNALVCPK CGRSESRKLS TYYRKLRLE
Length:199
Mass (Da):21,969
Last modified:September 1, 2009 - v1
Checksum:iC318B5D843342394
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS89558.1.
RefSeqiWP_015848778.1. NC_012883.1.
YP_002993907.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS89558; ACS89558; TSIB_0492.
GeneIDi8095479.
KEGGitsi:TSIB_0492.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS89558.1.
RefSeqiWP_015848778.1. NC_012883.1.
YP_002993907.1. NC_012883.1.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi604354.TSIB_0492.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS89558; ACS89558; TSIB_0492.
GeneIDi8095479.
KEGGitsi:TSIB_0492.

Phylogenomic databases

eggNOGiCOG1096.
HOGENOMiHOG000222781.
KOiK07573.
OMAiCGNVETR.

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-512-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_00975. Exosome_Csl4.
InterProiIPR019495. EXOSC1.
IPR025721. Exosome_cplx_N_dom.
IPR030850. Exosome_Csl4_arc.
IPR012340. NA-bd_OB-fold.
IPR003029. Rbsml_prot_S1_RNA-bd_dom.
IPR022967. S1_dom.
[Graphical view]
PfamiPF14382. ECR1_N. 1 hit.
PF10447. EXOSC1. 1 hit.
[Graphical view]
SMARTiSM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 1 hit.
PROSITEiPS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
    Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
    Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MM 739 / DSM 12597Imported.

Entry informationi

Entry nameiC6A1R3_THESM
AccessioniPrimary (citable) accession number: C6A1R3
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 24, 2015
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.