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Protein
Submitted name:

Short-chain alcohol dehydrogenase

Gene

TSIB_0319

Organism
Thermococcus sibiricus (strain MM 739 / DSM 12597)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

Complete GO annotation...

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-325-MONOMER.
BRENDAi1.1.1.2. 12860.
1.1.1.71. 12860.

Names & Taxonomyi

Protein namesi
Submitted name:
Short-chain alcohol dehydrogenaseImported
Gene namesi
Ordered Locus Names:TSIB_0319Imported
OrganismiThermococcus sibiricus (strain MM 739 / DSM 12597)Imported
Taxonomic identifieri604354 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaeThermococcus
Proteomesi
  • UP000009079 Componenti: Chromosome

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi210 – 210Combined sources
Disulfide bondi210 – 210InterchainCombined sources

Interactioni

Protein-protein interaction databases

STRINGi604354.TSIB_0319.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3L77X-ray1.55A1-234[»]
3TN7X-ray1.68A/B1-234[»]
ProteinModelPortaliC6A190.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiC6A190.

Family & Domainsi

Phylogenomic databases

eggNOGiarCOG01265. Archaea.
COG4221. LUCA.
OMAiWDEVIAT.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

C6A190-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKVAVITGAS RGIGEAIARA LARDGYALAL GARSVDRLEK IAHELMQEQG
60 70 80 90 100
VEVFYHHLDV SKAESVEEFS KKVLERFGDV DVVVANAGLG YFKRLEELSE
110 120 130 140 150
EEFHEMIEVN LLGVWRTLKA FLDSLKRTGG LALVTTSDVS ARLIPYGGGY
160 170 180 190 200
VSTKWAARAL VRTFQIENPD VRFFELRPGA VDTYFGGSKP GKPKEKGYLK
210 220 230
PDEIAEAVRC LLKLPKDVRV EELMLRSVYQ RPEY
Length:234
Mass (Da):26,151
Last modified:September 1, 2009 - v1
Checksum:iDD2478A76FC17182
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS89385.1.
RefSeqiWP_015848605.1. NC_012883.1.

Genome annotation databases

EnsemblBacteriaiACS89385; ACS89385; TSIB_0319.
GeneIDi8095292.
KEGGitsi:TSIB_0319.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP001463 Genomic DNA. Translation: ACS89385.1.
RefSeqiWP_015848605.1. NC_012883.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3L77X-ray1.55A1-234[»]
3TN7X-ray1.68A/B1-234[»]
ProteinModelPortaliC6A190.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi604354.TSIB_0319.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiACS89385; ACS89385; TSIB_0319.
GeneIDi8095292.
KEGGitsi:TSIB_0319.

Phylogenomic databases

eggNOGiarCOG01265. Archaea.
COG4221. LUCA.
OMAiWDEVIAT.

Enzyme and pathway databases

BioCyciTSIB604354:GHMS-325-MONOMER.
BRENDAi1.1.1.2. 12860.
1.1.1.71. 12860.

Miscellaneous databases

EvolutionaryTraceiC6A190.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
IPR002347. SDR_fam.
[Graphical view]
PANTHERiPTHR24322. PTHR24322. 1 hit.
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PRINTSiPR00081. GDHRDH.
SUPFAMiSSF51735. SSF51735. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis."
    Mardanov A.V., Ravin N.V., Svetlitchnyi V.A., Beletsky A.V., Miroshnichenko M.L., Bonch-Osmolovskaya E.A., Skryabin K.G.
    Appl. Environ. Microbiol. 75:4580-4588(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MM 739 / DSM 12597Imported.
  2. "X-ray structure alcohol dehydrogenase from archaeon Thermococcus sibiricus complexed with 5-hydroxy-NADP."
    Lyashenko A.V., Lashkov A.A., Gabdoulkhakov A.G., Mikhailov A.M.
    Submitted (DEC-2009) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS), DISULFIDE BONDS.
  3. "Structural insight into the molecular basis of polyextremophilicity of short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus."
    Bezsudnova E.Y., Boyko K.M., Polyakov K.M., Dorovatovskiy P.V., Stekhanova T.N., Gumerov V.M., Ravin N.V., Skryabin K.G., Kovalchuk M.V., Popov V.O.
    Biochimie 94:2628-2638(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.68 ANGSTROMS), DISULFIDE BONDS.

Entry informationi

Entry nameiC6A190_THESM
AccessioniPrimary (citable) accession number: C6A190
Entry historyi
Integrated into UniProtKB/TrEMBL: September 1, 2009
Last sequence update: September 1, 2009
Last modified: June 8, 2016
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.